PMID- 36728247
OWN - NLM
STAT- MEDLINE
DCOM- 20230920
LR  - 20231003
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 133
IP  - 10
DP  - 2023 Oct
TI  - Human Leukocyte Antigen Genotyping of Idiopathic Subglottic Stenosis.
PG  - 2533-2539
LID - 10.1002/lary.30580 [doi]
AB  - OBJECTIVE: Despite recent scientific inquiry, idiopathic subglottic stenosis 
      (iSGS) remains an enigmatic disease. The consistent demographics of the affected 
      population suggest genetic factors may contribute to disease susceptibility. 
      Given the inflammation observed in the affected proximal airway mucosa, we 
      interrogated disease association with human leukocyte antigen (HLA) 
      polymorphisms. Polymorphisms in the HLA locus have previously been shown to 
      influence individuals' susceptibility to distinct inflammatory diseases. METHODS: 
      High-resolution HLA typing of 37 iSGS patients was compared with 1,242,890 
      healthy Caucasian controls of European ancestry from the USA National Marrow 
      Donor Program and 281 patients with granulomatosis with polyangiitis (GPA). 
      RESULTS: Complete HLA genotyping of an iSGS population showed no significant 
      associations when compared to a North American Caucasian control population. 
      Unlike GPA patients, iSGS was not associated with allele DPB1*04:01 nor did 
      allele homozygosity correlate with disease severity. CONCLUSIONS: There was not a 
      detectable HLA association observed in iSGS. These results support the concept 
      that iSGS possesses a distinct genetic architecture from GPA. If genetic 
      susceptibility exists in iSGS, it likely lies outside the HLA locus. LEVEL OF 
      EVIDENCE: NA, basic science Laryngoscope, 133:2533-2539, 2023.
CI  - (c) 2023 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Rohlfing, Matthew L
AU  - Rohlfing ML
AUID- ORCID: 0000-0002-8744-4098
AD  - Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, 
      Tennessee, USA.
FAU - Hillel, Alexander T
AU  - Hillel AT
AD  - Department of Otolaryngology, Johns Hopkins University, Baltimore, Maryland, USA.
FAU - Wohler, Elizabeth
AU  - Wohler E
AD  - McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, 
      Baltimore, Maryland, USA.
FAU - Sobreira, Nara
AU  - Sobreira N
AD  - McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, 
      Baltimore, Maryland, USA.
FAU - Phillips, Elizabeth J
AU  - Phillips EJ
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, 
      Tennessee, USA.
FAU - Mallal, Simon A
AU  - Mallal SA
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, 
      Tennessee, USA.
FAU - Gelbard, Alexander
AU  - Gelbard A
AUID- ORCID: 0000-0003-0078-1305
AD  - Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, 
      Tennessee, USA.
LA  - eng
GR  - R01 HL146401/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20230202
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Humans
MH  - Genotype
MH  - Constriction, Pathologic
MH  - *Laryngostenosis/genetics
MH  - Genetic Predisposition to Disease
MH  - Alleles
MH  - *Granulomatosis with Polyangiitis
PMC - PMC10394115
MID - NIHMS1864693
OTO - NOTNLM
OT  - antineutrophil cytoplasmic antibody-associated vasculitis
OT  - granulomatosis with polyangiitis
OT  - human leukocyte antigen
OT  - idiopathic subglottic stenosis
OT  - tracheal stenosis
COIS- Conflict of Interest Disclosures: None
EDAT- 2023/02/03 06:00
MHDA- 2023/09/20 06:42
PMCR- 2024/10/01
CRDT- 2023/02/02 08:35
PHST- 2022/12/13 00:00 [revised]
PHST- 2022/09/15 00:00 [received]
PHST- 2023/01/02 00:00 [accepted]
PHST- 2024/10/01 00:00 [pmc-release]
PHST- 2023/09/20 06:42 [medline]
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/02/02 08:35 [entrez]
AID - 10.1002/lary.30580 [doi]
PST - ppublish
SO  - Laryngoscope. 2023 Oct;133(10):2533-2539. doi: 10.1002/lary.30580. Epub 2023 Feb 
      2.