PMID- 36728412
OWN - NLM
STAT- MEDLINE
DCOM- 20230404
LR  - 20231027
IS  - 1460-2350 (Electronic)
IS  - 0268-1161 (Linking)
VI  - 38
IP  - 4
DP  - 2023 Apr 3
TI  - Dietary total antioxidant capacity and the risk of developing asthenozoospermia: 
      a hospital-based case-control study in China.
PG  - 537-548
LID - 10.1093/humrep/dead010 [doi]
AB  - STUDY QUESTION: Is dietary total antioxidant capacity (DTAC) associated with the 
      odds of developing asthenozoospermia in Chinese men? SUMMARY ANSWER: There is no 
      statistically significant association between DTAC indices and the odds of 
      developing asthenozoospermia. WHAT IS KNOWN ALREADY: Both diet and oxidative 
      stress may be related to sperm quality; however, few studies have investigated 
      the association between DTAC and sperm quality. STUDY DESIGN, SIZE, DURATION: 
      This case-control study was conducted from June 2020 to December 2020. Those 
      diagnosed with asthenozoospermia were assigned to the case group, whereas those 
      with normal sperm parameters were assigned to the control group. Data from a 
      total of 553 cases and 586 controls were included in the final analysis. 
      PARTICIPANTS/MATERIALS, SETTING, METHODS: Men who had been referred to the 
      infertility clinic of Shengjing Hospital of China Medical University were 
      enrolled. Dietary intake was assessed using a validated food frequency 
      questionnaire. DTAC was based on ferric-reducing ability of plasma (FRAP), total 
      oxygen radical absorbance capacity (T-ORAC), hydrophilic oxygen radical 
      absorbance capacity (H-ORAC), lipophilic oxygen radical absorbance capacity 
      (L-ORAC), total phenolics (TP), total radical-trapping antioxidant parameter 
      (TRAP), and Trolox equivalent antioxidant capacity (TEAC). Asthenozoospermia was 
      defined according to the criteria published in the fifth edition of the World 
      Health Organization laboratory manual for the examination and processing of human 
      semen. MAIN RESULTS AND THE ROLE OF CHANCE: No significant association was 
      observed between the DTAC indices and the odds of asthenozoospermia after 
      multivariable adjustment (T3 vs T1, odds ratio (OR) = 0.99, 95% CI: 0.73-1.33 for 
      FRAP; OR = 1.05, 95% CI: 0.77-1.42 for T-ORAC; OR = 0.88, 95% CI: 0.65-1.18 for 
      H-ORAC; OR = 0.98, 95% CI: 0.71-1.34 for L-ORAC; OR = 1.03, 95% CI: 0.76-1.39 for 
      TP; OR = 1.18, 95% CI: 0.87-1.59 for TRAP; and OR = 1.15, 95% CI: 0.85-1.55 for 
      TEAC). Both additive and multiplicative interaction analyses suggested that 
      smoking might modify the association of T-ORAC with the odds of developing 
      asthenozoospermia (relative excess risk due to interaction = 0.45, 95% CI: 
      0.07-0.83, attributable proportion due to interaction = 0.46, 95% CI: 0.07-0.84 
      for additive interaction; P = 0.033 for multiplicative interaction). LIMITATIONS, 
      REASONS FOR CAUTION: Recall bias and protopathic bias were inevitable in this 
      retrospective case-control study. The estimation accuracy of the DTAC indices may 
      have also affected the findings. WIDER IMPLICATIONS OF THE FINDINGS: To the best 
      of our knowledge, this is the first study to specifically investigate whether an 
      association exists between DTAC and the odds of developing asthenozoospermia. 
      Although no significant association was found, this study provides novel 
      information pertaining to the fields of nutrition and human reproduction. STUDY 
      FUNDING/COMPETING INTEREST(S): This work was supported by the JieBangGuaShuai 
      Project of Liaoning Province (2021JH1/10400050), the Shengjing Hospital Clinical 
      Research Project (M0071), and the Outstanding Scientific Fund of Shengjing 
      Hospital (M1150). All authors have no competing interests to disclose. TRIAL 
      REGISTRATION NUMBER: N/A.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of European 
      Society of Human Reproduction and Embryology. All rights reserved. For 
      permissions, please email: journals.permissions@oup.com.
FAU - Huang, Donghui
AU  - Huang D
AD  - Department of Clinical Epidemiology, Shengjing Hospital of China Medical 
      University, Shenyang, China.
AD  - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, 
      Liaoning, China.
FAU - Zhang, Yixiao
AU  - Zhang Y
AD  - Department of Urology, Shengjing Hospital of China Medical University, Shenyang, 
      China.
FAU - Wang, Xiaobin
AU  - Wang X
AD  - Center for Reproductive Medicine, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Guo, Renhao
AU  - Guo R
AD  - Center for Reproductive Medicine, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Leng, Xu
AU  - Leng X
AD  - Center for Reproductive Medicine, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Du, Qiang
AU  - Du Q
AD  - Center for Reproductive Medicine, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Wu, Qijun
AU  - Wu Q
AUID- ORCID: 0000-0001-9421-5114
AD  - Department of Clinical Epidemiology, Shengjing Hospital of China Medical 
      University, Shenyang, China.
AD  - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, 
      Liaoning, China.
AD  - Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical 
      University, Shenyang, China.
AD  - Key Laboratory of Reproductive and Genetic Medicine (China Medical University), 
      National Health Commission, Shenyang, China.
FAU - Pan, Bochen
AU  - Pan B
AUID- ORCID: 0000-0002-1184-1003
AD  - Center for Reproductive Medicine, Shengjing Hospital of China Medical University, 
      Shenyang, China.
FAU - Zhao, Yuhong
AU  - Zhao Y
AUID- ORCID: 0000-0002-6806-521X
AD  - Department of Clinical Epidemiology, Shengjing Hospital of China Medical 
      University, Shenyang, China.
AD  - Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease, 
      Liaoning, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
RN  - 0 (Antioxidants)
SB  - IM
CIN - J Urol. 2023 Nov;210(5):810-811. PMID: 37615274
MH  - Humans
MH  - Male
MH  - *Asthenozoospermia/epidemiology
MH  - Case-Control Studies
MH  - Antioxidants
MH  - Semen
MH  - Retrospective Studies
MH  - Diet/adverse effects
OTO - NOTNLM
OT  - asthenozoospermia
OT  - case-control study
OT  - dietary total antioxidant capacity
OT  - non-enzymatic antioxidant capacity
OT  - sperm quality
EDAT- 2023/02/03 06:00
MHDA- 2023/04/04 06:42
CRDT- 2023/02/02 08:57
PHST- 2022/11/04 00:00 [received]
PHST- 2023/01/06 00:00 [revised]
PHST- 2023/04/04 06:42 [medline]
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/02/02 08:57 [entrez]
AID - 7024613 [pii]
AID - 10.1093/humrep/dead010 [doi]
PST - ppublish
SO  - Hum Reprod. 2023 Apr 3;38(4):537-548. doi: 10.1093/humrep/dead010.