PMID- 36728846
OWN - NLM
STAT- MEDLINE
DCOM- 20230216
LR  - 20231216
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 71
IP  - 6
DP  - 2023 Feb 15
TI  - Structure and IgE Cross-Reactivity among Cashew, Pistachio, Walnut, and Peanut 
      Vicilin-Buried Peptides.
PG  - 2990-2998
LID - 10.1021/acs.jafc.2c07061 [doi]
AB  - Peanut and tree-nut allergies are frequently comorbid for reasons not completely 
      understood. Vicilin-buried peptides (VBPs) are an emerging family of food 
      allergens whose conserved structural fold could mediate peanut/tree-nut 
      co-allergy. Peptide microarrays were used to identify immunoglobulin E (IgE) 
      epitopes from the N-terminus of the vicilin allergens Ara h 1, Ana o 1, Jug r 2, 
      and Pis v 3 using serum from three patient diagnosis groups: monoallergic to 
      either peanuts or cashew/pistachio, or dual allergic. IgE binding peptides were 
      highly prevalent in the VBP domains AH1.1, AO1.1, JR2.1, and PV3.1, but not in 
      AO1.2, JR2.2, JR2.3, and PV3.2 nor the unstructured regions. The IgE profiles did 
      not correlate with diagnosis group. The structure of the VBPs from cashew and 
      pistachio was solved using solution-NMR. Comparisons of structural features 
      suggest that the VBP scaffold from peanuts and tree-nuts can support 
      cross-reactivity. This may help understand comorbidity and cross-reactivity 
      despite a distant evolutionary origin.
FAU - Foo, Alexander C Y
AU  - Foo ACY
AD  - Genome Integrity and Structural Biology Laboratory, National Institute of 
      Environmental Health Sciences, 111 T.W. Alexander Drive, MD-MR01, Durham, North 
      Carolina 27709, United States.
FAU - Nesbit, Jacqueline B
AU  - Nesbit JB
AD  - Agricultural Research Service, United States Department of Agriculture, 1100 
      Allen Toussaint Boulevard, New Orleans, Louisiana 70124, United States.
FAU - Gipson, Stephen A Y
AU  - Gipson SAY
AUID- ORCID: 0000-0001-5173-3309
AD  - Agricultural Research Service, United States Department of Agriculture, 1100 
      Allen Toussaint Boulevard, New Orleans, Louisiana 70124, United States.
FAU - DeRose, Eugene F
AU  - DeRose EF
AUID- ORCID: 0000-0003-0112-1296
AD  - Genome Integrity and Structural Biology Laboratory, National Institute of 
      Environmental Health Sciences, 111 T.W. Alexander Drive, MD-MR01, Durham, North 
      Carolina 27709, United States.
FAU - Cheng, Hsiaopo
AU  - Cheng H
AD  - Agricultural Research Service, United States Department of Agriculture, 1100 
      Allen Toussaint Boulevard, New Orleans, Louisiana 70124, United States.
FAU - Hurlburt, Barry K
AU  - Hurlburt BK
AUID- ORCID: 0000-0001-5863-9542
AD  - Agricultural Research Service, United States Department of Agriculture, 1100 
      Allen Toussaint Boulevard, New Orleans, Louisiana 70124, United States.
FAU - Kulis, Michael D
AU  - Kulis MD
AD  - Department of Pediatrics, University of North Carolina School of Medicine, Chapel 
      Hill, North Carolina 27599-7220, United States.
FAU - Kim, Edwin H
AU  - Kim EH
AD  - Department of Pediatrics, University of North Carolina School of Medicine, Chapel 
      Hill, North Carolina 27599-7220, United States.
FAU - Dreskin, Stephen C
AU  - Dreskin SC
AD  - Division of Allergy and Clinical Immunology, University of Colorado Denver School 
      of Medicine, Aurora, Colorado 80045-2560, United States.
FAU - Mustafa, Shahzad
AU  - Mustafa S
AD  - Rochester Regional Health, University of Rochester School of Medicine and 
      Dentistry, Rochester, New York 14642, United States.
FAU - Maleki, Soheila J
AU  - Maleki SJ
AUID- ORCID: 0000-0002-6056-9958
AD  - Agricultural Research Service, United States Department of Agriculture, 1100 
      Allen Toussaint Boulevard, New Orleans, Louisiana 70124, United States.
FAU - Mueller, Geoffrey A
AU  - Mueller GA
AUID- ORCID: 0000-0001-8361-5323
AD  - Genome Integrity and Structural Biology Laboratory, National Institute of 
      Environmental Health Sciences, 111 T.W. Alexander Drive, MD-MR01, Durham, North 
      Carolina 27709, United States.
LA  - eng
GR  - R01 AI099029/AI/NIAID NIH HHS/United States
GR  - P30 ES010126/ES/NIEHS NIH HHS/United States
GR  - R01 AI165866/AI/NIAID NIH HHS/United States
GR  - R01 AI077653/AI/NIAID NIH HHS/United States
GR  - R21 AI135397/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20230202
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Peptides)
RN  - 9067-60-1 (vicilin protein, plant)
SB  - IM
MH  - Humans
MH  - Allergens/chemistry/immunology
MH  - *Anacardium/chemistry
MH  - *Arachis/chemistry
MH  - *Immunoglobulin E/immunology
MH  - *Juglans/chemistry
MH  - Nut Hypersensitivity/diagnosis
MH  - Nuts/chemistry
MH  - Peptides/chemistry/immunology
MH  - *Pistacia/chemistry
MH  - Cross Reactions
PMC - PMC10402694
MID - NIHMS1916798
OTO - NOTNLM
OT  - allergen
OT  - peanut
OT  - tree-nut
OT  - vicilin-buried peptide
COIS- The authors declare no competing financial interest.
EDAT- 2023/02/03 06:00
MHDA- 2023/02/17 06:00
PMCR- 2023/08/04
CRDT- 2023/02/02 10:23
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/02/17 06:00 [medline]
PHST- 2023/02/02 10:23 [entrez]
PHST- 2023/08/04 00:00 [pmc-release]
AID - 10.1021/acs.jafc.2c07061 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2023 Feb 15;71(6):2990-2998. doi: 10.1021/acs.jafc.2c07061. 
      Epub 2023 Feb 2.