PMID- 36729308
OWN - NLM
STAT- MEDLINE
DCOM- 20230403
LR  - 20230421
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Print)
IS  - 0940-5429 (Linking)
VI  - 60
IP  - 5
DP  - 2023 May
TI  - Compensatory mechanisms from different exercise intensities in type 2 diabetes: a 
      secondary analysis of a 1-year randomized controlled trial.
PG  - 645-654
LID - 10.1007/s00592-023-02038-7 [doi]
AB  - AIMS: This investigation aimed to determine the effect of different intensities 
      of training on non-exercise physical activity (NEPA) and estimated thermogenesis 
      (NEAT) from a 1-year exercise randomized controlled trial (RCT) in individuals 
      with type 2 diabetes mellitus (T2DM) on non-training days. Additionally, changes 
      in NEPA and estimated NEAT in those who failed (low-responders) or succeeded 
      (high-responders) in attaining exercise-derived clinically meaningful reductions 
      in body weight (BW) and fat mass (FM) (i.e., 6% for FM and 3% for BW) was 
      assessed. METHODS: Individuals with T2DM (n = 80) were enrolled in a RCT with 
      three groups: resistance training combined with moderate-intensity continuous 
      training (MICT) or high-intensity interval training (HIIT) and a control group. 
      Of the 80 participants, 56 (completed data) were considered for this secondary 
      analysis. NEPA and estimated NEAT were obtained by accelerometry and body 
      composition through dual-energy X-ray absorptiometry. RESULTS: After adjustments, 
      no time*group interactions were found for estimated NEAT in the MICT (beta = - 5.33, 
      p = 0.366) and HIIT (beta = - 5.70, p = 0.283), as well as for NEPA in the MICT 
      (beta = - 452.83, p = 0.833) and HIIT (beta = - 2770.76, p = 0.201), when compared to 
      controls. No compensatory changes in NEPA and estimated NEAT were observed when 
      considering both low-responders and high-responders to FM and BW when compared to 
      controls. CONCLUSIONS: Both MICT and HIIT did not result in any compensatory 
      changes in estimated NEAT and NEPA with the intervention on non-training days. 
      Moreover, no changes in estimated NEAT and NEPA were found when categorizing our 
      participants as low-responders and high-responders to FM and BW when compared to 
      controls. Trial registration clinicaltrials.gov ID. NCT03144505.
CI  - (c) 2023. The Author(s).
FAU - Correia, Ines R
AU  - Correia IR
AD  - Faculdade de Motricidade Humana, Exercise and Health Laboratory, CIPER, 
      Universidade de Lisboa Estrada da Costa, 1499-002, Cruz-Quebrada, Portugal.
FAU - Hetherington-Rauth, Megan
AU  - Hetherington-Rauth M
AD  - Faculdade de Motricidade Humana, Exercise and Health Laboratory, CIPER, 
      Universidade de Lisboa Estrada da Costa, 1499-002, Cruz-Quebrada, Portugal.
FAU - Magalhaes, Joao P
AU  - Magalhaes JP
AD  - Faculdade de Motricidade Humana, Exercise and Health Laboratory, CIPER, 
      Universidade de Lisboa Estrada da Costa, 1499-002, Cruz-Quebrada, Portugal.
FAU - Judice, Pedro B
AU  - Judice PB
AD  - Faculdade de Motricidade Humana, Exercise and Health Laboratory, CIPER, 
      Universidade de Lisboa Estrada da Costa, 1499-002, Cruz-Quebrada, Portugal.
AD  - CIDEFES - Centro de Investigacao Em Desporto, Educacao Fisica E Exercicio E 
      Saude, Universidade Lusofona, Lisbon, Portugal.
FAU - Rosa, Gil B
AU  - Rosa GB
AD  - Faculdade de Motricidade Humana, Exercise and Health Laboratory, CIPER, 
      Universidade de Lisboa Estrada da Costa, 1499-002, Cruz-Quebrada, Portugal.
FAU - Henriques-Neto, Duarte
AU  - Henriques-Neto D
AD  - Faculdade de Motricidade Humana, Exercise and Health Laboratory, CIPER, 
      Universidade de Lisboa Estrada da Costa, 1499-002, Cruz-Quebrada, Portugal.
FAU - Manas, Asier
AU  - Manas A
AD  - GENUD Toledo Research Group, University of Castilla-La Mancha, Toledo, Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), Madrid, Spain.
FAU - Ara, Ignacio
AU  - Ara I
AD  - GENUD Toledo Research Group, University of Castilla-La Mancha, Toledo, Spain.
FAU - Silva, Analiza M
AU  - Silva AM
AD  - Faculdade de Motricidade Humana, Exercise and Health Laboratory, CIPER, 
      Universidade de Lisboa Estrada da Costa, 1499-002, Cruz-Quebrada, Portugal.
FAU - Sardinha, Luis B
AU  - Sardinha LB
AUID- ORCID: 0000-0002-6230-6027
AD  - Faculdade de Motricidade Humana, Exercise and Health Laboratory, CIPER, 
      Universidade de Lisboa Estrada da Costa, 1499-002, Cruz-Quebrada, Portugal. 
      lsardinha@fmh.ulisboa.pt.
LA  - eng
SI  - ClinicalTrials.gov/NCT03144505
GR  - UIDB/00447/2020/Fundacao para a Ciencia e a Tecnologia/
GR  - SFRH/BD/149394/2019/Fundacao para a Ciencia e a Tecnologia/
GR  - SFRH/BD/ 85742/2012/Fundacao para a Ciencia e a Tecnologia/
GR  - SFRH/BPD/115977/2016/Fundacao para a Ciencia e a Tecnologia/
GR  - 2020.07856.BD/Fundacao para a Ciencia e a Tecnologia/
GR  - 2020/Fundacao para a Ciencia e a Tecnologia/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20230202
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/therapy
MH  - Exercise
MH  - Body Composition
MH  - Body Weight
PMC - PMC10063485
OTO - NOTNLM
OT  - Compensation
OT  - Diabetes mellitus
OT  - HIIT
OT  - NEAT
OT  - NEPA
OT  - Spontaneous activity
COIS- The authors report there are no conflicts of interest to declare.
EDAT- 2023/02/03 06:00
MHDA- 2023/04/03 06:42
PMCR- 2023/02/02
CRDT- 2023/02/02 11:22
PHST- 2022/11/03 00:00 [received]
PHST- 2023/01/17 00:00 [accepted]
PHST- 2023/04/03 06:42 [medline]
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/02/02 11:22 [entrez]
PHST- 2023/02/02 00:00 [pmc-release]
AID - 10.1007/s00592-023-02038-7 [pii]
AID - 2038 [pii]
AID - 10.1007/s00592-023-02038-7 [doi]
PST - ppublish
SO  - Acta Diabetol. 2023 May;60(5):645-654. doi: 10.1007/s00592-023-02038-7. Epub 2023 
      Feb 2.