PMID- 36729904
OWN - NLM
STAT- MEDLINE
DCOM- 20230206
LR  - 20230215
IS  - 1555-8576 (Electronic)
IS  - 1538-4047 (Print)
IS  - 1538-4047 (Linking)
VI  - 24
IP  - 1
DP  - 2023 Dec 31
TI  - Integrating DOI in T classification improves the predictive performance of 
      laryngeal cancer staging.
PG  - 2169040
LID - 10.1080/15384047.2023.2169040 [doi]
LID - 2169040
AB  - It has been recognized that depth of invasion (DOI) is closely associated with 
      patient survival for most types of cancer. The purpose of this study was to 
      determine the DOI optimal cutoff value and its prognostic value in laryngeal 
      squamous carcinoma (LSCC). Most importantly, we evaluated the prognostic 
      performance of five candidate modified T-classification models in patients with 
      LSCC. LSCC patients from Harbin Medical University Cancer Hospital and Chinese 
      Academy of Medical Sciences Cancer Hospital were divided into training group 
      (n = 412) and validation group (n = 147). The primary outcomes were overall 
      survival (OS) and relapse-free survival (RFS), and the effect of DOI on prognosis 
      was analyzed using a multivariable regression model. We identified the optimal 
      model based on its simplicity, goodness of fit and Harrell's consistency index. 
      Further independent testing was performed on the external validation queue. The 
      nomograms was constructed to predict an individual's OS rate at one, three, and 
      five years. In multivariate analysis, we found significant associations between 
      DOI and OS (Depth of Medium-risk invasion HR, 2.631; P < .001. Depth of high-risk 
      invasion: HR, 5.287; P < .001) and RFS (Depth of high-risk invasion: HR, 1.937; P 
      = .016). Model 4 outperformed the American Joint Committee on Cancer (AJCC) 
      staging system based on a low Akaike information criterion score, improvement in 
      the concordance index, and Kaplan-Meier curves. Inclusion of DOI in the current 
      AJCC staging system can improve the differentiation of T classification in LSCC 
      patients.
FAU - Wang, Xueying
AU  - Wang X
AD  - Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central 
      South University, changsha, China.
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin, China.
FAU - Cao, Kui
AU  - Cao K
AD  - Department of Laboratory, Harbin Medical University Cancer Hospital, Harbin, 
      China.
FAU - Guo, Erliang
AU  - Guo E
AD  - Department of Surgery, the 2nd Affiliated Hospital of Harbin Medical University, 
      Harbin, China.
FAU - Mao, Xionghui
AU  - Mao X
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin, China.
FAU - An, Changming
AU  - An C
AD  - Department of Head and Neck Surgery, Chinese National Cancer Center & Chinese 
      Academy of Medical Sciences Cancer Hospital, Beijing, China.
FAU - Guo, Lunhua
AU  - Guo L
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin, China.
FAU - Zhang, Cong
AU  - Zhang C
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin, China.
FAU - Yang, Xianguang
AU  - Yang X
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin, China.
FAU - Sun, Ji
AU  - Sun J
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin, China.
FAU - Yang, Weiwei
AU  - Yang W
AD  - Department of Pathology, Harbin Medical University, Harbin, China.
FAU - Li, Xiaomei
AU  - Li X
AD  - Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, 
      China.
FAU - Miao, Susheng
AU  - Miao S
AUID- ORCID: 0000-0002-7701-9362
AD  - Department of Head and Neck Surgery, Harbin Medical University Cancer Hospital, 
      Harbin, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Biol Ther
JT  - Cancer biology & therapy
JID - 101137842
SB  - IM
MH  - Humans
MH  - Neoplasm Staging
MH  - *Laryngeal Neoplasms
MH  - Neoplasm Recurrence, Local
MH  - Prognosis
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - *Head and Neck Neoplasms
MH  - Retrospective Studies
PMC - PMC9897798
OTO - NOTNLM
OT  - American Joint Committee on Cancer (AJCC)
OT  - Laryngeal squamous cell carcinoma (LSCC)
OT  - depth of invasion (DOI)
OT  - overall survival (OS)
OT  - relapse-free survival (RFS)
COIS- The authors declare that they have no Conflict of Interest.
EDAT- 2023/02/03 06:00
MHDA- 2023/02/07 06:00
PMCR- 2023/02/02
CRDT- 2023/02/02 12:53
PHST- 2023/02/02 12:53 [entrez]
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/02/07 06:00 [medline]
PHST- 2023/02/02 00:00 [pmc-release]
AID - 2169040 [pii]
AID - 10.1080/15384047.2023.2169040 [doi]
PST - ppublish
SO  - Cancer Biol Ther. 2023 Dec 31;24(1):2169040. doi: 10.1080/15384047.2023.2169040.