PMID- 36730595
OWN - NLM
STAT- MEDLINE
DCOM- 20240229
LR  - 20240229
IS  - 1937-1578 (Electronic)
IS  - 1935-1089 (Linking)
VI  - 18
IP  - 2
DP  - 2024 Mar 1
TI  - DIFFUSE POSTERIOR SCLERITIS ASSOCIATED WITH HUMAN LEUKOCYTE ANTIGEN-B14* MANAGED 
      WITH MULTIMODAL IMAGING: CASE REPORT AND REVIEW OF THE LITERATURE.
PG  - 255-258
LID - 10.1097/ICB.0000000000001373 [doi]
AB  - PURPOSE: To report a case of posterior scleritis in a human leukocyte antigen 
      (HLA)-B*14-positive patient, highlighting the crucial role of multimodal imaging 
      and of autoimmune systemic disease screening for the diagnosis. METHODS: Case 
      report. RESULTS: A 73-year-old woman, complaining of ocular discomfort in right 
      eye, presented conjunctival hyperemia, keratic precipitates involving the 
      anterior segment and four chorioretinal elevations with macular folds at fundus 
      examination. Multimodal imaging and systemic diagnostic workup were performed. 
      While awaiting results, topical corticosteroid was prescribed. Four days later, 
      worsening of exudative chorioretinal was detected. Except for erythrocyte 
      sedimentation rate, tests were negative, whereas molecular typing of HLA genes 
      was positive for HLA-B*14. Diagnosis of posterior scleritis was confirmed by 
      ultrasound examination while diagnosis of ankylosing spondylitis was made by 
      rheumatologist. The patient was given systemic corticosteroid, and one month 
      later, the posterior segment was unremarkable. CONCLUSION: HLA-B*14 may configure 
      as a causal factor, so autoimmune systemic disease screening should rule this out 
      in the management of posterior scleritis, which should be diagnosed on the basis 
      of multimodal imaging.
FAU - Raneri, Marco
AU  - Raneri M
AD  - Eye Clinic, Melegnano Hospital, Vizzolo Predabissi, Italy.
FAU - Fossataro, Federica
AU  - Fossataro F
FAU - Martines, Francesco
AU  - Martines F
FAU - Maione, Giulio
AU  - Maione G
FAU - Pece, Alfredo
AU  - Pece A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Retin Cases Brief Rep
JT  - Retinal cases & brief reports
JID - 101298744
RN  - 0 (Glucocorticoids)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Female
MH  - Humans
MH  - Aged
MH  - *Scleritis/diagnosis/complications
MH  - Glucocorticoids/therapeutic use
MH  - Eye
MH  - HLA-B Antigens
MH  - HLA Antigens
EDAT- 2023/02/03 06:00
MHDA- 2024/02/29 06:43
CRDT- 2023/02/02 14:42
PHST- 2024/02/29 06:43 [medline]
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/02/02 14:42 [entrez]
AID - 01271216-990000000-00109 [pii]
AID - 10.1097/ICB.0000000000001373 [doi]
PST - ppublish
SO  - Retin Cases Brief Rep. 2024 Mar 1;18(2):255-258. doi: 
      10.1097/ICB.0000000000001373.