PMID- 36732037
OWN - NLM
STAT- MEDLINE
DCOM- 20230321
LR  - 20230323
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 108
IP  - 4
DP  - 2023 Apr
TI  - Effect of early childhood development interventions delivered by healthcare 
      providers to improve cognitive outcomes in children at 0-36 months: a systematic 
      review and meta-analysis.
PG  - 247-257
LID - 10.1136/archdischild-2022-324506 [doi]
AB  - OBJECTIVE: To determine the effect of early childhood development interventions 
      delivered by healthcare providers (HCP-ECD) on child cognition and maternal 
      mental health. DESIGN: Systematic review, meta-analysis. SETTING: Healthcare 
      setting or home. PARTICIPANTS: Infants under 1 month of age. INTERVENTIONS: 
      HCP-ECD interventions that supported responsive caregiving, early learning and 
      motor stimulation. MEDLINE, EMBASE, Cochrane Central Register of Controlled 
      Trials, Health Technology Assessment Database, Database of Abstracts of Reviews 
      of Effects and Cochrane Database of Systematic Reviews were searched until 15 
      November 2021. Studies reporting prespecified outcomes were pooled using standard 
      meta-analytical methods. MAIN OUTCOME MEASURES: Cognitive development in children 
      at 0-36 months. RESULTS: Forty-two randomised controlled trials with 15 557 
      infants were included in the narrative synthesis. Twenty-seven trials were 
      included in the meta-analyses. Pooled data from 13 trials suggest that HCP-ECD 
      interventions may improve cognitive outcomes in children between 0 and 36 months 
      (Bayley Scales of Infant Development version IIII (BSID-III) mean difference (MD) 
      2.65; 95% CI 0.61 to 4.70; 2482 participants; low certainty of evidence). Pooled 
      data from nine trials suggest improvements in motor development (BSID-III MD 
      4.01; 95% CI 1.54 to 6.48; 1437 participants; low certainty of evidence). There 
      was no evidence of improvement in maternal mental health (standardised MD -0.13; 
      95% CI -0.28 to 0.03; 2806 participants; 11 trials; low certainty of evidence). 
      CONCLUSIONS: We report promising evidence, particularly for cognitive and motor 
      outcomes, of the effect of HCP-ECD interventions. However, effect sizes were 
      small, and the certainty of evidence ranged from very low to moderate. Additional 
      high-quality research is required. PROSPERO REGISTRATION NUMBER: CRD42019122021.
CI  - (c) Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Hirve, Raeena
AU  - Hirve R
AD  - Women and Children's Health, King's College London, London, UK.
FAU - Adams, Claire
AU  - Adams C
AD  - Edith Cowan University, Joondalup, Western Australia, Australia.
FAU - Kelly, Clare B
AU  - Kelly CB
AUID- ORCID: 0000-0002-8215-4796
AD  - Women and Children's Health, King's College London, London, UK.
FAU - McAullay, Daniel
AU  - McAullay D
AD  - Edith Cowan University, Joondalup, Western Australia, Australia.
FAU - Hurt, Lisa
AU  - Hurt L
AD  - Population Medicine, Cardiff University, Cardiff, UK.
FAU - Edmond, Karen M
AU  - Edmond KM
AUID- ORCID: 0000-0001-5421-0511
AD  - Women and Children's Health, King's College London, London, UK 
      karen.edmond@kcl.ac.uk.
FAU - Strobel, Natalie
AU  - Strobel N
AD  - Edith Cowan University, Joondalup, Western Australia, Australia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20230202
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
MH  - Infant
MH  - Child
MH  - Humans
MH  - Child, Preschool
MH  - *Child Development
MH  - *Mental Health
MH  - Health Personnel
MH  - Cognition
OTO - NOTNLM
OT  - Child Development
OT  - Primary Health Care
COIS- Competing interests: None declared.
EDAT- 2023/02/03 06:00
MHDA- 2023/03/22 06:00
CRDT- 2023/02/02 21:13
PHST- 2022/06/03 00:00 [received]
PHST- 2023/01/07 00:00 [accepted]
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/03/22 06:00 [medline]
PHST- 2023/02/02 21:13 [entrez]
AID - archdischild-2022-324506 [pii]
AID - 10.1136/archdischild-2022-324506 [doi]
PST - ppublish
SO  - Arch Dis Child. 2023 Apr;108(4):247-257. doi: 10.1136/archdischild-2022-324506. 
      Epub 2023 Feb 2.