PMID- 36732561
OWN - NLM
STAT- MEDLINE
DCOM- 20230206
LR  - 20230317
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Feb 2
TI  - Low thigh muscle strength in relation to myosteatosis in patients with type 2 
      diabetes mellitus.
PG  - 1957
LID - 10.1038/s41598-022-24002-1 [doi]
LID - 1957
AB  - This study aimed to investigate the association of thigh muscle fat infiltration 
      by quantitative MRI with muscle strength in patients with type 2 diabetes 
      mellitus (T2DM). Seventy T2DM patients and sixty control subjects (71 males; age: 
      52 +/- 8 years) underwent 3.0T MRI and isokinetic muscle strength measurements to 
      obtain the skeletal muscle index (SMI), intermuscular adipose tissue (IMAT) 
      proton density fat fraction (PDFF), intramuscular fat (IMF) PDFF, peak torque 
      (PT) and total work (TW) of knee extensors and flexors. The differences of 
      measurements between T2DM patients and asymptomatic volunteers were compared. 
      Multivariate regression analysis was used to determine significant predictors of 
      thigh extension and flexion strength. The SMI, IMAT and IMF PDFF of thigh muscles 
      in T2DM patients were higher than that in the control group (p < 0.001), while PT 
      and TW were lower than those in the control subjects (p < 0.05). Both IMF and 
      IMAT PDFF were negatively correlated with PT, TW in participants with T2DM 
      (extensors: r = - 0.72, - 0.70, p < 0.001; r = - 0.62, - 0.56, p < 0.05. flexors: 
      r = - 0.37, - 0.43, p < 0.05; r = - 0.39, - 0.46, p < 0.05). Moderate and strong 
      correlations between HOMA-IR and muscle strength measurements, muscle PDFFs were 
      observed in extensors and flexors. IMF PDFF and age were the statistically 
      significant predictor of PT and TW of extensors of thigh in multivariate 
      regression analysis. Therefore, the thigh muscle PDFF increased was associated 
      with muscle strength decreased in T2DM patients beyond SMI. Age are also 
      important factors influencing thigh muscle PDFF and strength in T2DM patients.
CI  - (c) 2023. The Author(s).
FAU - Huang, Yilong
AU  - Huang Y
AD  - Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Yan, Jun
AU  - Yan J
AD  - Department of Medical Imaging, The Affiliated Qujing Hospital of Kunming Medical 
      University, Qujing, China.
FAU - Zhu, Hongli
AU  - Zhu H
AD  - Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Zhang, Zhenguang
AU  - Zhang Z
AD  - Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Jiang, Yuanming
AU  - Jiang Y
AD  - Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Zhang, Xuxiang
AU  - Zhang X
AD  - Department of Endocrinology, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Wu, Yiran
AU  - Wu Y
AD  - Department of Rehabilitation, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Lu, Jiahang
AU  - Lu J
AD  - Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Cun, Hanxue
AU  - Cun H
AD  - Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - He, Bo
AU  - He B
AD  - Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical 
      University, Kunming, China. hebo_ydyy@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230202
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Male
MH  - Humans
MH  - Adult
MH  - Middle Aged
MH  - *Thigh
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Muscle, Skeletal/diagnostic imaging
MH  - Muscle Strength/physiology
MH  - Magnetic Resonance Imaging
PMC - PMC9895033
COIS- The authors declare no competing interests.
EDAT- 2023/02/03 06:00
MHDA- 2023/02/07 06:00
PMCR- 2023/02/02
CRDT- 2023/02/02 23:42
PHST- 2022/09/07 00:00 [received]
PHST- 2022/11/08 00:00 [accepted]
PHST- 2023/02/02 23:42 [entrez]
PHST- 2023/02/03 06:00 [pubmed]
PHST- 2023/02/07 06:00 [medline]
PHST- 2023/02/02 00:00 [pmc-release]
AID - 10.1038/s41598-022-24002-1 [pii]
AID - 24002 [pii]
AID - 10.1038/s41598-022-24002-1 [doi]
PST - epublish
SO  - Sci Rep. 2023 Feb 2;13(1):1957. doi: 10.1038/s41598-022-24002-1.