PMID- 36733193
OWN - NLM
STAT- MEDLINE
DCOM- 20230721
LR  - 20230721
IS  - 1873-4294 (Electronic)
IS  - 1568-0266 (Linking)
VI  - 23
IP  - 13
DP  - 2023
TI  - Metal-Organic Framework in Pharmaceutical Drug Delivery.
PG  - 1155-1170
LID - 10.2174/1568026623666230202122519 [doi]
AB  - Metal-organic frameworks (MOFs) are porous, crystalline materials made up of 
      organic ligands and metal ions/metal clusters linked by coordinative bonds. This 
      large family is becoming increasingly popular for drug delivery due to their 
      tuneable porosity, chemical composition, size and shape, and ease of surface 
      functionalization. There has been a growing interest over the last decades in the 
      design of engineered MOFs with controlled sizes for a variety of biomedical 
      applications. Starting with the MOFs classification adapted for drug delivery 
      systems (DDSs) based on the types of constituting metals and ligands. MOFs are 
      appealing drug delivery vehicles because of their substantial drug absorption 
      capacity and slow-release processes, which protect and convey sensitive drug 
      molecules to target areas. Other guest materials have been incorporated into MOFs 
      to create MOF-composite materials, which have added additional functionalities 
      such as externally triggered drug release, improved pharmacokinetics, and 
      diagnostic aids. Magnetic nanoparticles in MOFs for MRI image contrast and 
      polymer coatings that increase blood circulation time are examples of 
      synthetically adaptable MOF-composites. By including photosensitizers, which 
      exert lethal effects on cancer cells by converting tumour oxygen into reactive 
      singlet oxygen ((1)O(2)), metalorganic frameworks have been employed for 
      photodynamic treatment (PDT) of malignancies among a multitude of nanosized 
      therapies. Importantly, a variety of representative MOF applications are 
      described from the perspectives of pharmaceutics, disease therapy, and advanced 
      drug delivery systems. However, because of their weak conductivity, selectivity, 
      and lack of modification sites, MOF materials' uses in electrochemical biosensing 
      are restricted. MOF-based composites provide excellent electrical conductivity 
      and robust catalytic activity by adding functionalized nanoparticles into MOF 
      structures, which process benefits over single component MOFs.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Kundu, Sudipto
AU  - Kundu S
AD  - Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of 
      Higher Education & Research Ooty, Nilgiris, Tamilnadu, India.
FAU - Swaroop, Akey Krishna
AU  - Swaroop AK
AD  - Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of 
      Higher Education & Research Ooty, Nilgiris, Tamilnadu, India.
FAU - Selvaraj, Jubie
AU  - Selvaraj J
AUID- ORCID: 0000-0002-4633-6621
AD  - Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of 
      Higher Education & Research Ooty, Nilgiris, Tamilnadu, India.
LA  - eng
PT  - Journal Article
PL  - United Arab Emirates
TA  - Curr Top Med Chem
JT  - Current topics in medicinal chemistry
JID - 101119673
RN  - 0 (Metal-Organic Frameworks)
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Ligands)
RN  - 0 (Polymers)
RN  - 0 (Metals)
RN  - 0 (Excipients)
SB  - IM
MH  - Humans
MH  - *Metal-Organic Frameworks/chemistry
MH  - Pharmaceutical Preparations
MH  - Ligands
MH  - Drug Delivery Systems
MH  - Polymers
MH  - Metals/chemistry
MH  - *Neoplasms/drug therapy
MH  - Excipients
OTO - NOTNLM
OT  - Antitumor agents
OT  - Biomedical application.
OT  - Biosensing
OT  - Drug delivery system
OT  - Metal organic framework
OT  - Photodynamic treatment
EDAT- 2023/02/04 06:00
MHDA- 2023/07/21 06:44
CRDT- 2023/02/03 01:08
PHST- 2022/07/26 00:00 [received]
PHST- 2022/11/28 00:00 [revised]
PHST- 2022/12/16 00:00 [accepted]
PHST- 2023/07/21 06:44 [medline]
PHST- 2023/02/04 06:00 [pubmed]
PHST- 2023/02/03 01:08 [entrez]
AID - CTMC-EPUB-129237 [pii]
AID - 10.2174/1568026623666230202122519 [doi]
PST - ppublish
SO  - Curr Top Med Chem. 2023;23(13):1155-1170. doi: 10.2174/1568026623666230202122519.