PMID- 36734315
OWN - NLM
STAT- MEDLINE
DCOM- 20230510
LR  - 20230511
IS  - 2045-7634 (Electronic)
IS  - 2045-7634 (Linking)
VI  - 12
IP  - 8
DP  - 2023 Apr
TI  - Preoperative accuracy of diagnostic evaluation of urachal carcinoma.
PG  - 9106-9115
LID - 10.1002/cam4.5648 [doi]
AB  - BACKGROUND: We analyzed the clinical data of patients with urachal carcinoma 
      (UrC) in order to strengthen urologists' understanding of UrC and improve 
      preoperative diagnosis. METHODS: The clinical data of 37 patients with UrC 
      admitted to our hospital from October 2005 to April 2022 were retrospectively 
      analyzed, and 40 patients with urothelial carcinoma (UCa) of bladder were 
      enrolled as the control group. We compared and analyzed the imaging, cystoscopy 
      and immunohistochemistry, serum tumor markers, fluorescence in situ hybridization 
      (FISH) of UrC and bladder UCa for early diagnosis and evaluation of diagnostic 
      accuracy. RESULTS: A total of 37 patients with UrC were enrolled in this study, 
      including 30 males and seven females, with a median age of 52.00 (44.50-63.50) 
      years. Imaging and cystoscopy suggest that UrC grows primarily outside the 
      bladder cavity and is found in the middle line of the dome or anterior wall of 
      the bladder. There was a significant difference in tumor location between the UrC 
      group and the UCa group (10.13 mm vs. -7.06 mm, p < 0.001). Immunohistochemistry 
      revealed that CK20 and CDX-2 were both diffusely and strongly positive. beta-catenin 
      was strongly positive in cytoplasm and membrane, but negative in nuclear 
      staining. Carcinoembryonic antigen (CEA) and carbohydrate antigen 72-4 (CA724) 
      expression levels were significantly higher in the UrC group than in the UCa 
      group (p < 0.05). In the diagnosis of UrC, the area under the curve (AUC) of CEA 
      combined with CA724 was the greatest. FISH's sensitivity in diagnosing UrC (5/7, 
      71.43%) was not significantly different from that of UCa (71.43% vs. 77.50%, 
      p = 0.659). Imaging examination has the highest sensitivity and specificity among 
      the accuracy evaluation of different diagnostic methods. CONCLUSIONS: Imaging and 
      cystoscopy are the powerful diagnostic methods for UrC. Serum tumor markers may 
      assist in diagnosis, prognosis, and monitoring. Positive urine FISH can easily 
      misdiagnose UrC as UCa.
CI  - (c) 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
FAU - Ke, Chunjin
AU  - Ke C
AUID- ORCID: 0000-0002-1533-9053
AD  - Department of Urology, Tongji Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology (HUST), Wuhan, China.
FAU - Hu, Zhiquan
AU  - Hu Z
AD  - Department of Urology, Tongji Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology (HUST), Wuhan, China.
FAU - Yang, Chunguang
AU  - Yang C
AD  - Department of Urology, Tongji Hospital of Tongji Medical College, Huazhong 
      University of Science and Technology (HUST), Wuhan, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230203
PL  - United States
TA  - Cancer Med
JT  - Cancer medicine
JID - 101595310
RN  - 0 (Carcinoembryonic Antigen)
RN  - 0 (Biomarkers, Tumor)
RN  - Urachal cancer
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - *Urinary Bladder Neoplasms/diagnosis/surgery/pathology
MH  - *Carcinoma, Transitional Cell
MH  - Carcinoembryonic Antigen
MH  - Retrospective Studies
MH  - In Situ Hybridization, Fluorescence
MH  - Biomarkers, Tumor
PMC - PMC10166928
OTO - NOTNLM
OT  - cystoscopy
OT  - diagnosis
OT  - imaging
OT  - serum tumor markers
OT  - urachal carcinoma
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/04 06:00
MHDA- 2023/05/10 06:42
PMCR- 2023/02/03
CRDT- 2023/02/03 05:54
PHST- 2023/01/15 00:00 [revised]
PHST- 2022/11/01 00:00 [received]
PHST- 2023/01/16 00:00 [accepted]
PHST- 2023/05/10 06:42 [medline]
PHST- 2023/02/04 06:00 [pubmed]
PHST- 2023/02/03 05:54 [entrez]
PHST- 2023/02/03 00:00 [pmc-release]
AID - CAM45648 [pii]
AID - 10.1002/cam4.5648 [doi]
PST - ppublish
SO  - Cancer Med. 2023 Apr;12(8):9106-9115. doi: 10.1002/cam4.5648. Epub 2023 Feb 3.