PMID- 36735856 OWN - NLM STAT- MEDLINE DCOM- 20230207 LR - 20231109 IS - 2575-3126 (Electronic) IS - 2575-3126 (Linking) VI - 17 IP - 2 DP - 2023 Feb 1 TI - Implementing Preoperative Penicillin Allergy Testing in Surgical Patients. PG - e01659 LID - 10.1213/XAA.0000000000001659 [doi] AB - Penicillin allergy is the most reported immunoglobulin E (IgE)-mediated reaction. About 10% of the general population and 20% of hospitalized patients have a history of penicillin allergy. Unconfirmed penicillin allergy with subsequent administration of second-line antibiotics has been associated with increased morbidity. However, when penicillin allergy testing is performed, the incidence of IgE-mediated reactions is extremely low; in fact, the negative predictive value of penicillin allergy testing exceeds 99%. This article aims to briefly describe implementing safe penicillin allergy testing as a routine test during the preoperative evaluation of surgical patients. CI - Copyright (c) 2023 International Anesthesia Research Society. FAU - Gupta, Ravindra Alok AU - Gupta RA AD - From the Department of Anesthesiology, Northwestern University, Chicago, Illinois. FAU - Lee, Howard AU - Lee H FAU - Okocha, Obianuju AU - Okocha O LA - eng PT - Journal Article DEP - 20230203 PL - United States TA - A A Pract JT - A&A practice JID - 101714112 RN - 0 (Penicillins) RN - 0 (Anti-Bacterial Agents) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - Penicillins/adverse effects MH - Skin Tests/adverse effects MH - Anti-Bacterial Agents/adverse effects MH - *Drug Hypersensitivity/diagnosis/etiology MH - Immunoglobulin E MH - *Hypersensitivity/complications COIS- The authors declare no conflicts of interest. EDAT- 2023/02/04 06:00 MHDA- 2023/02/08 06:00 CRDT- 2023/02/03 14:52 PHST- 2023/02/03 14:52 [entrez] PHST- 2023/02/04 06:00 [pubmed] PHST- 2023/02/08 06:00 [medline] AID - 02054229-202302000-00003 [pii] AID - 10.1213/XAA.0000000000001659 [doi] PST - epublish SO - A A Pract. 2023 Feb 3;17(2):e01659. doi: 10.1213/XAA.0000000000001659. eCollection 2023 Feb 1.