PMID- 36736919
OWN - NLM
STAT- MEDLINE
DCOM- 20230411
LR  - 20230412
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 211
DP  - 2023 Apr
TI  - Gut-brain axis through the lens of gut microbiota and their relationships with 
      Alzheimer's disease pathology: Review and recommendations.
PG  - 111787
LID - S0047-6374(23)00013-1 [pii]
LID - 10.1016/j.mad.2023.111787 [doi]
AB  - Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of 
      people worldwide. Growing evidence suggests that the gut microbiome (GM) plays a 
      pivotal role in the pathogenesis of AD through the microbiota-gut-brain axis 
      (MGB). Alterations in GM composition and diversity have been observed in both 
      animal models and in human patients with AD. GM dysbiosis has been implicated in 
      increased intestinal permeability, blood-brain barrier (BBB) impairment, 
      neuroinflammation and the development of hallmarks of AD. Further elucidation of 
      the role of GM in AD could pave way for the development of holistic predictive 
      methods for determining AD risk and progression of disease. Furthermore, 
      accumulating evidence suggests that GM modulation could alleviate adverse 
      symptoms of AD or serve as a preventive measure. In addition, increasing evidence 
      shows that Type 2 Diabetes Mellitus (T2DM) is often comorbid with AD, with common 
      GM alterations and inflammatory response, which could chart the development of 
      GM-related treatment interventions for both diseases. We conclude by exploring 
      the therapeutic potential of GM in alleviating symptoms of AD and in reducing 
      risk. Furthermore, we also propose future directions in AD research, namely fecal 
      microbiota transplantation (FMT) and precision medicine.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - L, Krishaa
AU  - L K
AD  - Department of Biomedical Engineering, College of Design and Engineering, National 
      University of Singapore, Singapore.
FAU - Ng, Ted Kheng Siang
AU  - Ng TKS
AD  - Arizona State University, Edson College of Nursing and Health Innovation, USA. 
      Electronic address: ted.ng@asu.edu.
FAU - Wee, Hai Ning
AU  - Wee HN
AD  - Cardiovascular and Metabolic Disorders Programme, Duke-NUS Medical School, 
      Singapore.
FAU - Ching, Jianhong
AU  - Ching J
AD  - Cardiovascular and Metabolic Disorders Programme, Duke-NUS Medical School, 
      Singapore; KK Research Centre, KK Women's and Children's Hospital, Singapore. 
      Electronic address: jianhong.ching@duke-nus.edu.sg.
LA  - eng
PT  - Journal Article
DEP - 20230201
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Alzheimer Disease/pathology
MH  - *Gastrointestinal Microbiome/physiology
MH  - Brain-Gut Axis
MH  - *Diabetes Mellitus, Type 2
MH  - Brain/pathology
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Fecal microbiota transplantation (FMT)
OT  - Gut dysbiosis
OT  - Gut microbiota
OT  - Microbiota-gut-brain axis
OT  - Neurodegeneration
OT  - Neuroinflammation
OT  - Type 2 diabetes mellitus (T2DM)
COIS- Conflicts of Interest The authors declare no conflict of interest.
EDAT- 2023/02/04 06:00
MHDA- 2023/04/11 06:42
CRDT- 2023/02/03 19:33
PHST- 2022/09/11 00:00 [received]
PHST- 2023/01/05 00:00 [revised]
PHST- 2023/01/30 00:00 [accepted]
PHST- 2023/04/11 06:42 [medline]
PHST- 2023/02/04 06:00 [pubmed]
PHST- 2023/02/03 19:33 [entrez]
AID - S0047-6374(23)00013-1 [pii]
AID - 10.1016/j.mad.2023.111787 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2023 Apr;211:111787. doi: 10.1016/j.mad.2023.111787. Epub 2023 
      Feb 1.