PMID- 36737400
OWN - NLM
STAT- MEDLINE
DCOM- 20231028
LR  - 20231028
IS  - 2472-1727 (Electronic)
VI  - 115
IP  - 6
DP  - 2023 Apr 1
TI  - Embryo-fetal safety evaluation of ondansetron in rats.
PG  - 605-613
LID - 10.1002/bdr2.2154 [doi]
AB  - BACKGROUND: Ondansetron is a 5HT3 receptor antagonist, used to mitigate the 
      effects of nausea and vomiting after chemotherapy or surgery. Since nausea and 
      vomiting are common experiences during the first trimester of pregnancy, this 
      antiemetic has been the main drug used during this period. METHODS: To evaluate 
      the effects of ondansetron on the embryo-fetal development, which are still very 
      contradictory, pregnant rats were exposed to therapeutic doses of ondansetron 
      (1.7 or 2.5 mg/kg) daily, from gestational day (GD) 6 to 15. RESULTS: No clinical 
      signs of toxicity were observed in dams during the treatment. Although the 
      hemato-biochemical parameters were similar among the groups, histological 
      changes, as well as a reduction in the weight of kidney were found in the treated 
      dams. After fetal examination, no visceral and skeletal abnormalities were 
      observed in treated fetuses. CONCLUSION: In conclusion, therapeutic doses of 
      ondansetron have low teratogenic potential in rats. These data provide important 
      information about the drug safety during pregnancy.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Reis, Ana Carolina Casali
AU  - Reis ACC
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
FAU - Jorge, Barbara Campos
AU  - Jorge BC
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
FAU - da Silva Moreira, Suyane
AU  - da Silva Moreira S
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
FAU - Stein, Julia
AU  - Stein J
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
FAU - Perdao, Carolina Barizan
AU  - Perdao CB
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
FAU - de Matos Manoel, Beatriz
AU  - de Matos Manoel B
AD  - College of Health Science, Federal University of Grande Dourados, Dourados, Mato 
      Grosso do Sul, Brazil.
FAU - Arena, Arielle Cristina
AU  - Arena AC
AUID- ORCID: 0000-0002-2373-9399
AD  - Department of Structural and Functional Biology, Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - UNESP, Botucatu, Sao Paulo, Brazil.
AD  - Center of Toxicological Assistance (CEATOX), Institute of Biosciences of 
      Botucatu, Universidade Estadual Paulista - Botucatu (UNESP), Botucatu, Sao Paulo, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230203
PL  - United States
TA  - Birth Defects Res
JT  - Birth defects research
JID - 101701004
RN  - 0 (Antiemetics)
RN  - 4AF302ESOS (Ondansetron)
SB  - IM
MH  - Animals
MH  - Female
MH  - Pregnancy
MH  - Rats
MH  - *Antiemetics/toxicity
MH  - *Embryo, Mammalian/drug effects
MH  - Nausea/drug therapy
MH  - *Ondansetron/toxicity
MH  - Vomiting/drug therapy
OTO - NOTNLM
OT  - kidney
OT  - nausea and vomiting
OT  - organogenesis
OT  - rats
OT  - safety
OT  - teratogenicity
EDAT- 2023/02/04 06:00
MHDA- 2023/03/21 06:00
CRDT- 2023/02/03 22:06
PHST- 2023/01/16 00:00 [revised]
PHST- 2022/09/22 00:00 [received]
PHST- 2023/01/23 00:00 [accepted]
PHST- 2023/02/04 06:00 [pubmed]
PHST- 2023/03/21 06:00 [medline]
PHST- 2023/02/03 22:06 [entrez]
AID - 10.1002/bdr2.2154 [doi]
PST - ppublish
SO  - Birth Defects Res. 2023 Apr 1;115(6):605-613. doi: 10.1002/bdr2.2154. Epub 2023 
      Feb 3.