PMID- 36738312
OWN - NLM
STAT- MEDLINE
DCOM- 20230512
LR  - 20230513
IS  - 1432-0878 (Electronic)
IS  - 0302-766X (Print)
IS  - 0302-766X (Linking)
VI  - 392
IP  - 2
DP  - 2023 May
TI  - Hyperlipidemia in tendon injury: chronicles of low-density lipoproteins.
PG  - 431-442
LID - 10.1007/s00441-023-03748-8 [doi]
AB  - Hyperlipidemia impacts millions of people globally and has been the major risk 
      factor for developing atherosclerosis and cardiovascular disease. Interestingly, 
      hyperlipidemic subjects exhibit increased incidence of rotator cuff tendon injury 
      (RCTI) and disorganization of tendon matrix. Low-density lipoproteins (LDL) and 
      its oxidized form (ox-LDL) play a crucial role in hyperlipidemia-driven 
      pro-inflammatory responses in multiple tissues including the tendon. The 
      signaling of oxLDL upregulates the inflammatory cytokines, chemokines, adhesion 
      molecules, and the activation of monocytes/macrophages/resident tendon cells and 
      matrix metalloproteinases impairing the tendon homeostasis resulting in the 
      alteration of extracellular matrix. In addition, the hyperlipidemia-driven immune 
      response and subsequent oxidative stress promote degenerative responses in the 
      tendon tissue. However, the pathological mechanisms underlying the occurrence of 
      RCTI in hyperlipidemia and the effect of ox-LDL in tendon matrix are currently 
      unknown. The present review focuses on the implications and perspectives of 
      LDL/oxLDL on the increased incidence of RCTI.
CI  - (c) 2023. The Author(s).
FAU - Fang, William H
AU  - Fang WH
AUID- ORCID: 0000-0003-1703-6969
AD  - Department of Translational Research, Western University of Health Sciences, 
      Pomona, CA, 91766, USA.
FAU - Bonavida, Victor
AU  - Bonavida V
AUID- ORCID: 0000-0003-0857-5477
AD  - Department of Translational Research, Western University of Health Sciences, 
      Pomona, CA, 91766, USA.
FAU - Agrawal, Devendra K
AU  - Agrawal DK
AUID- ORCID: 0000-0001-5445-0013
AD  - Department of Translational Research, Western University of Health Sciences, 
      Pomona, CA, 91766, USA.
FAU - Thankam, Finosh G
AU  - Thankam FG
AUID- ORCID: 0000-0001-7285-9808
AD  - Department of Translational Research, Western University of Health Sciences, 
      Pomona, CA, 91766, USA. FThankam@westernu.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230204
PL  - Germany
TA  - Cell Tissue Res
JT  - Cell and tissue research
JID - 0417625
RN  - 0 (Lipoproteins, LDL)
SB  - IM
MH  - Humans
MH  - *Hyperlipidemias/complications
MH  - Lipoproteins, LDL
MH  - *Atherosclerosis/pathology
MH  - *Tendon Injuries/complications
MH  - *Rotator Cuff Injuries
PMC - PMC10172214
OTO - NOTNLM
OT  - ECM disorganization
OT  - Hyperlipidemia
OT  - LDL
OT  - Rotator cuff tendon injury
OT  - oxLDL
COIS- The authors declare no competing interests.
EDAT- 2023/02/05 06:00
MHDA- 2023/05/12 07:06
PMCR- 2023/02/04
CRDT- 2023/02/04 11:12
PHST- 2022/08/04 00:00 [received]
PHST- 2023/01/25 00:00 [accepted]
PHST- 2023/05/12 07:06 [medline]
PHST- 2023/02/05 06:00 [pubmed]
PHST- 2023/02/04 11:12 [entrez]
PHST- 2023/02/04 00:00 [pmc-release]
AID - 10.1007/s00441-023-03748-8 [pii]
AID - 3748 [pii]
AID - 10.1007/s00441-023-03748-8 [doi]
PST - ppublish
SO  - Cell Tissue Res. 2023 May;392(2):431-442. doi: 10.1007/s00441-023-03748-8. Epub 
      2023 Feb 4.