PMID- 36738647
OWN - NLM
STAT- MEDLINE
DCOM- 20230224
LR  - 20230314
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 159
DP  - 2023 Mar
TI  - Altered functional connectivity of the default mode and dorsal attention network 
      in subjective cognitive decline.
PG  - 165-171
LID - S0022-3956(23)00047-X [pii]
LID - 10.1016/j.jpsychires.2023.01.040 [doi]
AB  - Subjective cognitive decline (SCD) is a clinical condition in which performance 
      on standardized cognitive tests does not indicate impairment like mild cognitive 
      impairment (MCI), but self-experienced cognitive capacity persistently declines. 
      We aimed to explore the functional connectivity (FC) characteristics of SCD 
      subjects compared to healthy controls and MCI patients. Resting-state functional 
      MRI was performed on 152 elderly subjects: 65 normal controls, 62 SCD subjects, 
      and 25 MCI patients. A seed-based FC analysis was performed to compare groups. 
      The major brain regions of the default mode network (DMN) and dorsal attention 
      network (DAN), large-scale brain networks disrupted in patients with dementia, 
      were selected as seed regions. As a result, the SCD group showed stronger FC than 
      the MCI group between DMN seeds and the supramarginal gyrus. Both the SCD and MCI 
      groups showed stronger FC between the left lateral parietal cortex and right 
      dorsolateral prefrontal cortex. In the FC analysis centred on DAN seeds, both the 
      SCD and MCI groups showed weaker FC of the right posterior intraparietal sulcus 
      in the left anterior cingulate cortex and the left insula, compared to those in 
      the control group. Within the SCD group, hyperconnectivity between the right 
      lateral parietal cortex and left supramarginal gyrus was significantly correlated 
      with better performance on the Controlled Oral Word Association Test. In 
      conclusion, the SCD group showed several DMN- and DAN-related FC alterations, 
      similar to the MCI group, but with distinct hyperconnectivity between DMN seeds 
      and the supramarginal gyrus. In particular, SCD has DMN-related FC patterns 
      distinct from those of MCI that are associated with verbal fluency retention.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Lee, Deokjong
AU  - Lee D
AD  - Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of 
      Medicine, Yongin, South Korea; Institute of Behavioral Science in Medicine, 
      Yonsei University College of Medicine, Seoul, South Korea.
FAU - Park, Jin Young
AU  - Park JY
AD  - Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of 
      Medicine, Yongin, South Korea; Institute of Behavioral Science in Medicine, 
      Yonsei University College of Medicine, Seoul, South Korea; Center for Digital 
      Health, Yongin Severance Hospital, Yonsei University Health System, Yongin, South 
      Korea. Electronic address: empathy@yuhs.ac.
FAU - Kim, Woo Jung
AU  - Kim WJ
AD  - Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of 
      Medicine, Yongin, South Korea; Institute of Behavioral Science in Medicine, 
      Yonsei University College of Medicine, Seoul, South Korea. Electronic address: 
      woojungkim@yuhs.ac.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230130
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Brain Mapping
MH  - Magnetic Resonance Imaging
MH  - Brain
MH  - *Cognitive Dysfunction
MH  - Parietal Lobe
OTO - NOTNLM
OT  - Default mode network
OT  - Functional connectivity
OT  - Subjective cognitive decline
COIS- Declarations of competing interest The authors declare no conflict of interest.
EDAT- 2023/02/05 06:00
MHDA- 2023/02/25 06:00
CRDT- 2023/02/04 18:15
PHST- 2022/07/25 00:00 [received]
PHST- 2022/12/23 00:00 [revised]
PHST- 2023/01/26 00:00 [accepted]
PHST- 2023/02/05 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2023/02/04 18:15 [entrez]
AID - S0022-3956(23)00047-X [pii]
AID - 10.1016/j.jpsychires.2023.01.040 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2023 Mar;159:165-171. doi: 10.1016/j.jpsychires.2023.01.040. 
      Epub 2023 Jan 30.