PMID- 36738836
OWN - NLM
STAT- MEDLINE
DCOM- 20230315
LR  - 20230315
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 197
DP  - 2023 Mar
TI  - Clinical expert consensus on the assessment and protection of pancreatic islet 
      beta-cell function in type 2 diabetes mellitus.
PG  - 110568
LID - S0168-8227(23)00043-8 [pii]
LID - 10.1016/j.diabres.2023.110568 [doi]
AB  - Islet beta-cell dysfunction is a basic pathophysiological characteristic of type 2 
      diabetes mellitus (T2DM). Appropriate assessment of islet beta-cell function is 
      beneficial to better management of T2DM. Protecting islet beta-cell function is 
      vital to delay the progress of type 2 diabetes mellitus. Therefore, the 
      Pancreatic Islet beta-cell Expert Panel of the Chinese Diabetes Society and 
      Endocrinology Society of Jiangsu Medical Association organized experts to draft 
      the "Clinical expert consensus on the assessment and protection of pancreatic 
      islet beta-cell function in type 2 diabetes mellitus." This consensus suggests that 
      beta-cell function can be clinically assessed using blood glucose-based methods or 
      methods that combine blood glucose and endogenous insulin or C-peptide levels. 
      Some measures, including weight loss and early and sustained euglycemia control, 
      could effectively protect islet beta-cell function, and some newly developed drugs, 
      such as Sodium-glucose cotransporter-2 inhibitor and Glucagon-like peptide-1 
      receptor agonists, could improve islet beta-cell function, independent of glycemic 
      control.
CI  - Copyright (c) 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
FAU - Zhu, Jian
AU  - Zhu J
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Han, Junfeng
AU  - Han J
AD  - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University 
      Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, 
      Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China.
FAU - Liu, Liehua
AU  - Liu L
AD  - Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Liu, Yu
AU  - Liu Y
AD  - Endocrinology Department, Sir Run Run Hospital of Nanjing Medical University, 
      Nanjing, China.
FAU - Xu, Wen
AU  - Xu W
AD  - Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory 
      of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, 
      Guangzhou, China.
FAU - Li, Xiaomu
AU  - Li X
AD  - Department of Endocrine and Metabolism, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Yang, Lin
AU  - Yang L
AD  - National Clinical Research Center for Metabolic Diseases, Key Laboratory of 
      Diabetes Immunology, Ministry of Education, Department of Metabolism and 
      Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 
      China.
FAU - Gu, Yong
AU  - Gu Y
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Tang, Wei
AU  - Tang W
AD  - Department of Endocrinology, Geriatric Hospital of Nanjing Medical University, 
      Nanjing, China.
FAU - Shi, Yongquan
AU  - Shi Y
AD  - Department of Endocrinology, Changzheng Hospital, The Navy Military Medical 
      University, Shanghai, China.
FAU - Ye, Shandong
AU  - Ye S
AD  - Department of Endocrinology, Anhui Provincial Hospital, Hefei, China.
FAU - Hua, Fei
AU  - Hua F
AD  - Department of Endocrinology, The First People's Hospital of Changzhou, Changzhou, 
      China.
FAU - Xiang, Guangda
AU  - Xiang G
AD  - Department of Endocrinology, General Hospital of Central Theater Command of 
      Chinese People' s Liberation Army, Wuhan, China.
FAU - Liu, Ming
AU  - Liu M
AD  - Department of Endocrinology, General Hospital, Tianjin Medical University, 
      Tianjin, China.
FAU - Sun, Zilin
AU  - Sun Z
AD  - Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of 
      Medicine, Southeast University, Nanjing, China.
FAU - Su, Qing
AU  - Su Q
AD  - Department of Endocrinology, Xinhua Hospital, Shanghai Jiaotong University, 
      Shanghai, China.
FAU - Li, Xiaoying
AU  - Li X
AD  - Department of Endocrine and Metabolism, Zhongshan Hospital, Fudan University, 
      Shanghai, China.
FAU - Li, Yuxiu
AU  - Li Y
AD  - Department of Endocrinology, Peking Union Medical College Hospital, Beijing, 
      China.
FAU - Li, Yanbing
AU  - Li Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen 
      University, Guangzhou, China.
FAU - Li, Hong
AU  - Li H
AD  - Department of Endocrinology, First Affiliated Hospital of Kunming Medical 
      University, Kunming, China.
FAU - Li, Yiming
AU  - Li Y
AD  - Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai, China.
FAU - Yang, Tao
AU  - Yang T
AD  - Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Yang, Jing
AU  - Yang J
AD  - Department of Endocrinology, First Hospital of Shanxi Medical University, 
      Taiyuan, China.
FAU - Shi, Lixin
AU  - Shi L
AD  - Department of Endocrinology, Guiqian International General Hospital, Guiyang 
      550018, China.
FAU - Yu, Xuefeng
AU  - Yu X
AD  - Department of Endocrinology, Tongji Hospital, Tongji Medical College of Huazhong 
      University of Science & Technology, Wuhan, China.
FAU - Chen, Li
AU  - Chen L
AD  - Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, China.
FAU - Shao, Jiaqing
AU  - Shao J
AD  - Department of Endocrinology, the Affiliated Jinling Hospital of Nanjing Medical 
      University, General Hospital of Eastern Theater Command, Nanjing, China.
FAU - Liang, Jun
AU  - Liang J
AD  - Department of Endocrinology, Xuzhou Central Hospital, Xuzhou, China.
FAU - Han, Xiao
AU  - Han X
AD  - Key Laboratory of Human Functional Genomics of Jiangsu Province, School of Basic 
      Medical Science, Nanjing Medical University, Nanjing, China.
FAU - Xue, Yaomin
AU  - Xue Y
AD  - The First Clinical Medical Institute, Southern Medical University, Guangzhou, 
      China.
FAU - Ma, Jianhua
AU  - Ma J
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China. Electronic address: majianhua@china.com.
FAU - Zhu, Dalong
AU  - Zhu D
AD  - Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University 
      Medical School, Nanjing, China. Electronic address: zhudalong@nju.edu.cn.
FAU - Mu, Yiming
AU  - Mu Y
AD  - Department of Endocrinology, Chinese PLA General Hospital, Beijing, China. 
      Electronic address: muyiming@301hospital.com.cn.
CN  - Pancreatic Islet beta-cell Expert Panel of the Chinese Diabetes Society and 
      Endocrinology Society of Jiangsu Medical Association
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230203
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 0 (Sodium-Glucose Transporter 2 Inhibitors)
RN  - 0 (Insulin)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2
MH  - Blood Glucose
MH  - Consensus
MH  - *Sodium-Glucose Transporter 2 Inhibitors/pharmacology
MH  - Insulin/pharmacology
MH  - *Insulin-Secreting Cells
MH  - *Islets of Langerhans/physiology
OTO - NOTNLM
OT  - Expert consensus
OT  - Functional assessment
OT  - Intensive insulin therapy
OT  - Islets
OT  - Weight loss
OT  - beta-cell
COIS- Declaration of Competing Interest All authors declare no conflict of interests.
EDAT- 2023/02/05 06:00
MHDA- 2023/03/16 06:00
CRDT- 2023/02/04 19:23
PHST- 2022/09/08 00:00 [received]
PHST- 2023/01/08 00:00 [revised]
PHST- 2023/01/30 00:00 [accepted]
PHST- 2023/02/05 06:00 [pubmed]
PHST- 2023/03/16 06:00 [medline]
PHST- 2023/02/04 19:23 [entrez]
AID - S0168-8227(23)00043-8 [pii]
AID - 10.1016/j.diabres.2023.110568 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2023 Mar;197:110568. doi: 10.1016/j.diabres.2023.110568. 
      Epub 2023 Feb 3.