PMID- 36738844
OWN - NLM
STAT- MEDLINE
DCOM- 20230315
LR  - 20230626
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 377
DP  - 2023 Apr 15
TI  - Efficacy of CRT upgrade in pacemaker-induced cardiomyopathy in an outpatient 
      clinic - Results of a prospective registry.
PG  - 60-65
LID - S0167-5273(23)00119-5 [pii]
LID - 10.1016/j.ijcard.2023.01.077 [doi]
AB  - PURPOSE: The aim of this prospective, monocentric registry study was to 
      investigate whether upgrading to cardiac resynchronization therapy (CRT) in 
      pacemaker-induced cardiomyopathy (PICM) can improve left ventricular function in 
      typical outpatient clinical patients. METHODS: We screened for PICM in a 
      pacemaker outpatient clinic between 2017 and 2021. The follow-up period was 
      6 months. The primary endpoint was decreased left ventricular end systolic volume 
      (LVESV), and the responder criterion was decreased LVESV >15%. Secondary 
      endpoints were LVEF, NYHA class, device-associated complications and death. 
      RESULTS: 66 patients were newly diagnosed with PICM. 55 of them received a CRT 
      upgrade. For the primary endpoint, LVESV decreased from 101.6 +/- 48.2 ml to 
      75.9 +/- 35.8 ml (p < 0.001). Secondary endpoints were: a) LVEF increased from 
      31.5 +/- 5.4% to 46.1 +/- 7.6% (p < 0.001) and b) NYHA class improved by an average 
      of one class in both groups (p < 0.001). The overall complication rate was 1.8%. 
      CONCLUSIONS: CRT upgrade in outpatient clinic patients with PICM improves left 
      ventricular function and functional capacity and is associated with an acceptable 
      complication rate.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Christoph, Melzer
AU  - Christoph M
AD  - Herzschrittmacher- und ICD-Zentrum, Berlin, 10439 Berlin, Germany. Electronic 
      address: melzer.implantation@gmail.com.
FAU - Marius, Schwerg
AU  - Marius S
AD  - Department of Cardiology, Martin-Luther-Krankenhaus, 14193 Berlin, Germany.
FAU - Karl, Stangl
AU  - Karl S
AD  - Department of Cardiology and Angiology, Campus Mitte, Charite Universitatsmedizin 
      Berlin, 10117 Berlin, Germany.
FAU - Friedrich, Kohler
AU  - Friedrich K
AD  - Department of Cardiology and Angiology, Campus Mitte, Charite Universitatsmedizin 
      Berlin, 10117 Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20230202
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
CIN - Int J Cardiol. 2023 Jul 1;382:62. PMID: 36965637
MH  - Humans
MH  - *Cardiac Resynchronization Therapy/adverse effects
MH  - *Heart Failure/diagnosis
MH  - *Pacemaker, Artificial/adverse effects
MH  - *Cardiomyopathies/etiology/therapy
MH  - Ventricular Function, Left
MH  - Treatment Outcome
MH  - Stroke Volume
OTO - NOTNLM
OT  - Cardiac resynchronization therapy (CRT)
OT  - Pacemaker
OT  - Pacemaker-induced cardiomyopathy
COIS- Declaration of Competing Interest C. Melzer, M. Schwerg, K. Stangl and F. Kohler 
      declare that they have no competing interests.
EDAT- 2023/02/05 06:00
MHDA- 2023/03/16 06:00
CRDT- 2023/02/04 19:24
PHST- 2022/11/02 00:00 [received]
PHST- 2023/01/18 00:00 [revised]
PHST- 2023/01/26 00:00 [accepted]
PHST- 2023/02/05 06:00 [pubmed]
PHST- 2023/03/16 06:00 [medline]
PHST- 2023/02/04 19:24 [entrez]
AID - S0167-5273(23)00119-5 [pii]
AID - 10.1016/j.ijcard.2023.01.077 [doi]
PST - ppublish
SO  - Int J Cardiol. 2023 Apr 15;377:60-65. doi: 10.1016/j.ijcard.2023.01.077. Epub 
      2023 Feb 2.