PMID- 36741403
OWN - NLM
STAT- MEDLINE
DCOM- 20230209
LR  - 20230217
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - HLA and Non-HLA gene polymorphisms in autoimmune hepatitis patients of North 
      Indian adults.
PG  - 984083
LID - 10.3389/fimmu.2022.984083 [doi]
LID - 984083
AB  - Autoimmune hepatitis (AIH) is a chronic and progressive disease of the liver. 
      This is a multifactorial autoimmune disease with both environmental factors and 
      genetic factors playing a role in its pathogenesis. Certain environmental agents 
      like viruses, drugs, etc., can trigger the disease in a genetically susceptible 
      individual. The present study was aimed to explore the distribution of human 
      leukocyte antigen (HLA)-DRB1, Protein tyrosine phosphatase non-receptor type 22 
      (PTPN22) and Cytotoxic T-Lymphocyte-associated protein 4 (CTLA-4) polymorphisms 
      in North Indian adult AIH patients and their associations with clinical and 
      pathological characteristics associated with the disease. A total of 147 subjects 
      with 47 cases and 100 healthy controls were enrolled. Diagnosis of AIH was made 
      by Revised International Autoimmune Hepatitis Group scoring system. HLA-DRB1 
      Typing was done by Luminex-based reverse Sequence-Specific Oligonucleotide 
      Probing (SSOP). Single nucleotide variant (SNV) genotyping for CTLA-4 and PTPN22 
      was done by simple probe-based SNP arrays. Results indicated SLA positive AIH 
      patients are poor responders to therapy. A significant predispositional 
      association of HLA-DRB1*03 was observed in AIH patients from the North Indian 
      population (p= 0.0001, OR=4.83 (2.30-10.15). The frequency of the GG genotype of 
      CTLA-4 CT 60 was significantly increased in AIH patients compared to controls. 
      Multinomial analysis showed that CTLA-4 CT 60 is an independent predictor for 
      cases.
CI  - Copyright (c) 2023 Ahuja, Singh, Minz, Anand, Das and Taneja.
FAU - Ahuja, Nishtha
AU  - Ahuja N
AD  - Department of Histopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Singh, Jagdeep
AU  - Singh J
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Minz, Ranjana Walker
AU  - Minz RW
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Anand, Shashi
AU  - Anand S
AD  - Department of Immunopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Das, Ashim
AU  - Das A
AD  - Department of Histopathology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
FAU - Taneja, Sunil
AU  - Taneja S
AD  - Department of Hepatology, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India.
LA  - eng
PT  - Journal Article
DEP - 20230118
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (CTLA-4 Antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 22)
RN  - EC 3.1.3.48 (PTPN22 protein, human)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *CTLA-4 Antigen/genetics
MH  - Genotype
MH  - *Hepatitis, Autoimmune/genetics
MH  - HLA-DRB1 Chains/genetics
MH  - Polymorphism, Genetic
MH  - *Protein Tyrosine Phosphatase, Non-Receptor Type 22/genetics
PMC - PMC9891307
OTO - NOTNLM
OT  - CTLA-4
OT  - HLA
OT  - PTPN22
OT  - SLA
OT  - adults
OT  - autoimmune hepatitis
OT  - polymorphisms
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/07 06:00
MHDA- 2023/02/08 06:00
PMCR- 2022/01/01
CRDT- 2023/02/06 03:30
PHST- 2022/07/01 00:00 [received]
PHST- 2022/12/28 00:00 [accepted]
PHST- 2023/02/06 03:30 [entrez]
PHST- 2023/02/07 06:00 [pubmed]
PHST- 2023/02/08 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.984083 [doi]
PST - epublish
SO  - Front Immunol. 2023 Jan 18;13:984083. doi: 10.3389/fimmu.2022.984083. eCollection 
      2022.