PMID- 36741779
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230207
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 16
DP  - 2022
TI  - Cognitive impairment with Type 2 Diabetes Mellitus among community-dwelling older 
      adults in Chile: Prevalence, risk factors and cognitive characteristics.
PG  - 1070611
LID - 10.3389/fnhum.2022.1070611 [doi]
LID - 1070611
AB  - INTRODUCTION: The aim of this study is to determine prevalence and risk factors 
      of Cognitive Impairment (CI) and its association with Type 2 Diabetes Mellitus 
      (T2DM) in subjects aged 65 years and above. Additionally, we attempt to provide a 
      cognitive profile for T2DM group. METHODOLOGY: A cross-sectional analytical study 
      to assess CI was carried out. We evaluated a sample of community-dwelling 
      residents from Chile. All participants underwent a general interview, lifestyle 
      questionnaires and a comprehensive neuropsychological battery. Regression 
      analyses were performed to evaluate risk of CI with T2DM and influencing factors. 
      Results between groups in the different domains of the neuropsychological 
      assessment were compared by Student's t-tests and MANOVA. RESULTS: Among all 358 
      subjects, overall T2DM prevalence were 17.3%. The prevalence of CI was higher in 
      T2DM group compared to the healthy participants (30.7%, p < 0.001). The risk of 
      CI was 2.8 times higher in older people with T2DM compared to older people 
      without the diagnosis. Multiple regression analysis, adjusted for age and gender, 
      demonstrated that age, education, presence of dyslipidemia, and T2DM duration 
      were the predictor variables significantly associated with CI. T2DM group 
      performed worse on global cognitive performance, attention, language, verbal 
      memory, visual memory, visual constructional ability, and executive function. 
      After adjusting for significant covariates from multiple regression analysis, a 
      relationship between "cognition" and T2DM is still observed. Amnesic multi-domain 
      impairment was the specific cognitive identified pattern for T2DM group. 
      CONCLUSION: The present study confirms the high prevalence of CI with T2DM among 
      Chilean older adults in a community-based population. T2DM is significantly 
      associated with a higher risk of CI, and age, education, presence of 
      dyslipidemia, and duration of T2DM are risk factors. T2DM patients with CI are 
      impaired in multiple cognitive domains, even after adjusting covariables, 
      resulting in an amnesic multi-domain cognitive profile.
CI  - Copyright (c) 2023 Bozanic, Toro, Bello-Lepe, Hurtado-Oliva, Beyle, Valdes and 
      Formiga.
FAU - Bozanic, Agnieszka
AU  - Bozanic A
AD  - Facultad de Educacion y Ciencias Sociales, Universidad Andres Bello, Vina del 
      Mar, Chile.
FAU - Toro, Pablo
AU  - Toro P
AD  - Department of Psychiatry, Faculty of Medicine, Pontificia Universidad Catolica de 
      Chile, Santiago, Chile.
AD  - Advanced Center for Chronic Diseases, Pontificia Universidad Catolica de Chile, 
      Santiago, Chile.
FAU - Bello-Lepe, Sebastian
AU  - Bello-Lepe S
AD  - School of Speech Therapy, Valparaiso University, Vina del Mar, Chile.
FAU - Hurtado-Oliva, Javier
AU  - Hurtado-Oliva J
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Medical 
      Center Groningen, University of Groningen, Groningen, Netherlands.
FAU - Beyle, Christian
AU  - Beyle C
AD  - Psychology Department, Universidad Catolica de Temuco, Temuco, Chile.
FAU - Valdes, Catalina
AU  - Valdes C
AD  - Department of Health, Universidad de Los Lagos, Osorno, Chile.
FAU - Formiga, Francesc
AU  - Formiga F
AD  - Geriatric Unit, Internal Medicine, Hospital Universitari de Bellvitge, IDIBELL, 
      L'Hospitalet de Llobregat, Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20230119
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC9892451
OTO - NOTNLM
OT  - Mild Cognitive Impairment
OT  - Type 2 Diabetes Mellitus
OT  - cross-sectional study
OT  - dementia
OT  - prevalence
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/07 06:00
MHDA- 2023/02/07 06:01
PMCR- 2022/01/01
CRDT- 2023/02/06 03:35
PHST- 2022/10/15 00:00 [received]
PHST- 2022/12/19 00:00 [accepted]
PHST- 2023/02/06 03:35 [entrez]
PHST- 2023/02/07 06:00 [pubmed]
PHST- 2023/02/07 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2022.1070611 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2023 Jan 19;16:1070611. doi: 10.3389/fnhum.2022.1070611. 
      eCollection 2022.