PMID- 36741851
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230207
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 9
DP  - 2022
TI  - Stress CMR T1-mapping technique for assessment of coronary microvascular 
      dysfunction in a rabbit model of type II diabetes mellitus: Validation against 
      histopathologic changes.
PG  - 1066332
LID - 10.3389/fcvm.2022.1066332 [doi]
LID - 1066332
AB  - BACKGROUND: Coronary microvascular dysfunction (CMD) is an early character of 
      type 2 diabetes mellitus (T2DM), and is indicative of adverse events. The present 
      study aimed to validate the performance of the stress T1 mapping technique on 
      cardiac magnetic resonance (CMR) for identifying CMD from a histopathologic 
      perspective and to establish the time course of CMD-related parameters in a 
      rabbit model of T2DM. METHODS: New Zealand white rabbits (n = 30) were randomly 
      divided into a control (n = 8), T2DM 5-week (n = 6), T2DM 10-week (n = 9), and 
      T2DM 15-week (n = 7) groups. The CMR protocol included rest and adenosine 
      triphosphate (ATP) stress T1-mapping imaging using the 5b(20b)3b-modified 
      look-locker inversion-recovery (MOLLI) schema to quantify stress T1 response 
      (stress DeltaT1), and first-pass perfusion CMR to quantify myocardial perfusion 
      reserve index (MPRI). After the CMR imaging, myocardial tissue was subjected to 
      hematoxylin-eosin staining to evaluate pathological changes, Masson trichrome 
      staining to measure collagen volume fraction (CVF), and CD31 staining to measure 
      microvascular density (MVD). The associations between CMR parameters and 
      pathological findings were determined using Pearson correlation analysis. 
      RESULTS: The stress DeltaT1 values were 6.21 +/- 0.59%, 4.88 +/- 0.49%, 3.80 +/- 0.40%, and 
      3.06 +/- 0.54% in the control, T2DM 5-week, 10-week, and 15-week groups, 
      respectively (p < 0.001) and were progressively weakened with longer duration of 
      T2DM. Furthermore, a significant correlation was demonstrated between the stress 
      DeltaT1 vs. CVF and MVD (r = -0.562 and 0.886, respectively; p < 0.001). CONCLUSION: 
      The stress T1 response correlated well with the histopathologic measures in T2DM 
      rabbits, indicating that it may serve as a sensitive CMD-related indicator in 
      early T2DM.
CI  - Copyright (c) 2023 Ma, Liu, Hu, Chen, Liang, Zhou, Shang and Wang.
FAU - Ma, Peisong
AU  - Ma P
AD  - Department of Radiology, Southwest Hospital, Army Medical University, Third 
      Military Medical University, Chongqing, China.
AD  - Department of Radiology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Liu, Juan
AU  - Liu J
AD  - Department of Ultrasound, Southwest Hospital, Army Medical University, Third 
      Military Medical University, Chongqing, China.
FAU - Hu, Yurou
AU  - Hu Y
AD  - Department of Radiology, Southwest Hospital, Army Medical University, Third 
      Military Medical University, Chongqing, China.
FAU - Chen, Lin
AU  - Chen L
AD  - Department of Radiology, Southwest Hospital, Army Medical University, Third 
      Military Medical University, Chongqing, China.
FAU - Liang, Hongqin
AU  - Liang H
AD  - Department of Radiology, Southwest Hospital, Army Medical University, Third 
      Military Medical University, Chongqing, China.
FAU - Zhou, Xiaoyue
AU  - Zhou X
AD  - MR Collaboration, Siemens Healthineers Ltd., Shanghai, China.
FAU - Shang, Yongning
AU  - Shang Y
AD  - Department of Ultrasound, Southwest Hospital, Army Medical University, Third 
      Military Medical University, Chongqing, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Radiology, Southwest Hospital, Army Medical University, Third 
      Military Medical University, Chongqing, China.
LA  - eng
PT  - Journal Article
DEP - 20230120
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC9895118
OTO - NOTNLM
OT  - T1-mapping
OT  - adenosine triphosphate
OT  - cardiovascular magnetic resonance
OT  - coronary microvascular dysfunction
OT  - microvascular density
OT  - type 2 diabetes mellitus
COIS- XZ was employed by Siemens Healthineers Ltd. The remaining authors declare that 
      the research was conducted in the absence of any commercial or financial 
      relationships that could be construed as a potential conflict of interest.
EDAT- 2023/02/07 06:00
MHDA- 2023/02/07 06:01
PMCR- 2023/01/20
CRDT- 2023/02/06 03:36
PHST- 2022/10/10 00:00 [received]
PHST- 2022/12/28 00:00 [accepted]
PHST- 2023/02/06 03:36 [entrez]
PHST- 2023/02/07 06:00 [pubmed]
PHST- 2023/02/07 06:01 [medline]
PHST- 2023/01/20 00:00 [pmc-release]
AID - 10.3389/fcvm.2022.1066332 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2023 Jan 20;9:1066332. doi: 10.3389/fcvm.2022.1066332. 
      eCollection 2022.