PMID- 36742361
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230207
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Print)
IS  - 1792-1074 (Linking)
VI  - 25
IP  - 2
DP  - 2023 Feb
TI  - Prognostic value of estrogen receptors in patients who underwent prostatectomy 
      for non‑metastatic prostate cancer.
PG  - 78
LID - 10.3892/ol.2023.13664 [doi]
LID - 78
AB  - Estrogen receptors in prostate cancer (PCa) are a subject of debate. The aim of 
      the present study was to investigate whether estrogen receptor-alpha (ERalpha) and 
      estrogen receptor-beta (ERbeta) impact the biochemical recurrence (BCR) of 
      non-metastatic PCa after surgery. Following the application of the exclusion 
      criteria, data from 108 patients who underwent laparoscopic radical prostatectomy 
      between January 2011 and December 2019 were retrospectively evaluated. A total of 
      36 patients with BCR constituted the BCR group. The control group was formed 
      using the Propensity Score Matching (PSM) method with a 1:2 ratio, including 
      parameters with well-studied effects on BCR. The median follow-up time was 74.3 
      (range, 30-127.5) months in the BCR group and 66.6 (range, 31.5-130) months in 
      the control group. Pathology specimens from the two groups were 
      immunohistochemically stained with ERalpha and ERbeta antibodies. Logistic regression 
      analysis and survival analysis were performed. No differences in 
      clinicopathological characteristics were detected between the two groups. The 
      patients with ERalpha(-)/ERbeta(+) staining results had a significantly fewer BCRs than 
      other patients (P=0.024). In the logistic regression analysis, patients with 
      ERalpha(-)/ERbeta(+) PCa also had a significantly lower risk of recurrence (P=0.048). In 
      the survival analysis, the 5-year BCR-free survival rate of patients with 
      ERalpha(-)/ERbeta(+) PCa was higher than that of other patients (85.7 vs. 66.1%; 
      P=0.031). Excluding the effects of well-studied risk factors for recurrence by 
      the PSM method, the present study showed that ERalpha and ERbeta have prognostic value 
      for non-metastatic PCa. The 5-year BCR-free survival rate is significantly higher 
      in patients whose PCa tissue has ERalpha(-)/ERbeta(+) staining results.
CI  - Copyright (c) 2023, Spandidos Publications.
FAU - Aydin, Yavuz Mert
AU  - Aydin YM
AD  - Department of Urology, Bursa Uludag University, 16059 Bursa, Turkey.
FAU - Sahin, Ahmet Bilgehan
AU  - Sahin AB
AD  - Department of Medical Oncology, Bursa Uludag University, 16059 Bursa, Turkey.
FAU - Dolek, Rabia
AU  - Dolek R
AD  - Department of Pathology, Bursa Uludag University, 16059 Bursa, Turkey.
FAU - Vuruskan, Berna Aytac
AU  - Vuruskan BA
AD  - Department of Pathology, Bursa Uludag University, 16059 Bursa, Turkey.
FAU - Ocakoglu, Gokhan
AU  - Ocakoglu G
AD  - Department of Biostatistics, Bursa Uludag University, 16059 Bursa, Turkey.
FAU - Vuruskan, Hakan
AU  - Vuruskan H
AD  - Department of Urology, Bursa Uludag University, 16059 Bursa, Turkey.
FAU - Yavascaoglu, Ismet
AU  - Yavascaoglu I
AD  - Department of Urology, Bursa Uludag University, 16059 Bursa, Turkey.
FAU - Coskun, Burhan
AU  - Coskun B
AD  - Department of Urology, Bursa Uludag University, 16059 Bursa, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20230109
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC9853097
OTO - NOTNLM
OT  - biochemical recurrence-free survival
OT  - estrogen receptor-alpha
OT  - estrogen receptor-beta
OT  - laparoscopic radical prostatectomy
OT  - prostate cancer
COIS- The authors declare that they have no competing interests.
EDAT- 2023/02/07 06:00
MHDA- 2023/02/07 06:01
PMCR- 2023/01/09
CRDT- 2023/02/06 03:44
PHST- 2022/09/07 00:00 [received]
PHST- 2022/11/29 00:00 [accepted]
PHST- 2023/02/06 03:44 [entrez]
PHST- 2023/02/07 06:00 [pubmed]
PHST- 2023/02/07 06:01 [medline]
PHST- 2023/01/09 00:00 [pmc-release]
AID - OL-25-2-13664 [pii]
AID - 10.3892/ol.2023.13664 [doi]
PST - epublish
SO  - Oncol Lett. 2023 Jan 9;25(2):78. doi: 10.3892/ol.2023.13664. eCollection 2023 
      Feb.