PMID- 36743297 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230207 IS - 2040-6223 (Print) IS - 2040-6231 (Electronic) IS - 2040-6223 (Linking) VI - 14 DP - 2023 TI - Inheritance and innovation of the diagnosis of peripheral pulmonary lesions. PG - 20406223221146723 LID - 10.1177/20406223221146723 [doi] LID - 20406223221146723 AB - As the leading cause of cancer-related deaths worldwide, early detection and diagnosis are crucial to reduce the mortality of lung cancer. To date, the diagnosis of the peripheral pulmonary lesions (PPLs) remains a major unmet clinical need. The urgency of diagnosing PPLs has driven a series of development of the advanced bronchoscopy-guided techniques in the past decades, such as radial probe-endobronchial ultrasonography (RP-EBUS), virtual bronchoscopy navigation (VBN), electromagnetic navigation bronchoscopy (ENB), bronchoscopic transparenchymal nodule access (BTPNA), and robotic-assisted bronchoscopy. However, these techniques also have their own limitations. In this review, we would like to introduce the development of diagnostic techniques for PPLs, with a special focus on biopsy approaches and advanced guided bronchoscopy techniques by discussing their advantages, limitations, and future prospects. CI - (c) The Author(s), 2023. FAU - Xia, Yang AU - Xia Y AUID- ORCID: 0000-0003-2487-2244 AD - Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. AD - Cancer Center, Zhejiang University, Hangzhou, China. FAU - Li, Qin AU - Li Q AD - Key Laboratory of Respiratory Disease of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. AD - Cancer Center, Zhejiang University, Hangzhou, China. FAU - Zhong, Changgao AU - Zhong C AD - State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory, Guangzhou Institute of Respiratory Disease, Guangzhou, China. FAU - Wang, Kopen AU - Wang K AD - Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA. FAU - Li, Shiyue AU - Li S AD - State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory, Guangzhou Institute of Respiratory Disease, Guangzhou, China. LA - eng PT - Journal Article PT - Review DEP - 20230127 PL - United States TA - Ther Adv Chronic Dis JT - Therapeutic advances in chronic disease JID - 101532140 PMC - PMC9896091 OTO - NOTNLM OT - bronchoscopy OT - diagnosis OT - peripheral pulmonary lesion COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2023/02/07 06:00 MHDA- 2023/02/07 06:01 PMCR- 2023/01/27 CRDT- 2023/02/06 03:52 PHST- 2022/07/20 00:00 [received] PHST- 2022/12/05 00:00 [accepted] PHST- 2023/02/06 03:52 [entrez] PHST- 2023/02/07 06:00 [pubmed] PHST- 2023/02/07 06:01 [medline] PHST- 2023/01/27 00:00 [pmc-release] AID - 10.1177_20406223221146723 [pii] AID - 10.1177/20406223221146723 [doi] PST - epublish SO - Ther Adv Chronic Dis. 2023 Jan 27;14:20406223221146723. doi: 10.1177/20406223221146723. eCollection 2023.