PMID- 36747428
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230207
IS  - 2095-9281 (Electronic)
IS  - 2095-9273 (Linking)
VI  - 65
IP  - 11
DP  - 2020 Jun 15
TI  - Cathepsin C promotes the progression of periapical periodontitis.
PG  - 951-957
LID - S2095-9273(19)30704-2 [pii]
LID - 10.1016/j.scib.2019.12.006 [doi]
AB  - Although the role of cathepsin C (Cat C) in inflammation is gradually being 
      elucidated, its function in periapical periodontitis, which is one of the most 
      common infectious diseases worldwide, has not been studied. This study evaluated 
      a surgically-induced model of periapical periodontitis in cathepsin C (Cat C) 
      knock-down (KD) mice, which was constructed with a tetracycline operator, to 
      evaluate the role of Cat C in the pathogenesis and progression of periapical 
      periodontitis. Our results showed, for the first time, that there was a 
      statistically significant increase in the expression of Cat C as periapical 
      periodontitis progressed; this increase started from 1 week after surgery and 
      reached a peak at 3 weeks after surgery, before gradually decreasing. The volume 
      of periapical bone resorption in Cat C KD mice was significantly smaller than 
      that in wild-type mice at 3 and 4 weeks after surgery (P<0.05). Inflammatory cell 
      infiltration into the apical tissues of wild-type mice was also significantly 
      higher than that of Cat C KD mice. The expression of receptor activator of 
      nuclear factor-kappaB ligand (RANKL) in wild-type mice was also higher than that 
      in Cat C KD mice. The difference in the number of osteoclasts in the apical area 
      between the two groups was statistically significant after 2 weeks. Correlation 
      analysis showed that there was a significant correlation between Cat C and RANKL 
      expression (r= 0.835). Therefore, our data indicated that Cat C promoted the 
      apical inflammation and bone destruction in mice.
CI  - Copyright (c) 2019 Science China Press. Published by Elsevier B.V. All rights 
      reserved.
FAU - Yin, Wei
AU  - Yin W
AD  - The State Key Laboratory Breeding Base of Basic Science of Stomatology 
      (Hubei-MOST) & Key Laboratory of Oral Biomedicine (Ministry of Education), School 
      & Hospital of Stomatology, Wuhan University, Wuhan 430079, China; Department of 
      Biomedical Data Science, Geisel School of Medicine at Dartmouth College, One 
      Medical Center Drive, Lebanon, NH 03756, USA.
FAU - Dong, Ming
AU  - Dong M
AD  - School of Stomatology, Dalian Medical University, Dalian 116044, China.
FAU - Ye, Dandan
AU  - Ye D
AD  - Hospital of Stomatology, Yiwu City, Jinhua 322005, China.
FAU - Liu, Qicheng
AU  - Liu Q
AD  - School of Stomatology, Dalian Medical University, Dalian 116044, China.
FAU - Liu, Shuo
AU  - Liu S
AD  - School of Stomatology, Dalian Medical University, Dalian 116044, China.
FAU - Shi, Chun
AU  - Shi C
AD  - School of Stomatology, Dalian Medical University, Dalian 116044, China.
FAU - Bai, Hua
AU  - Bai H
AD  - School of Stomatology, Dalian Medical University, Dalian 116044, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - School of Stomatology, Dalian Medical University, Dalian 116044, China.
FAU - Yang, Xue
AU  - Yang X
AD  - School of Stomatology, Dalian Medical University, Dalian 116044, China.
FAU - Wang, Lina
AU  - Wang L
AD  - School of Stomatology, Dalian Medical University, Dalian 116044, China. 
      Electronic address: wanglina@dmu.edu.cn.
FAU - Niu, Weidong
AU  - Niu W
AD  - School of Stomatology, Dalian Medical University, Dalian 116044, China. 
      Electronic address: niu.wd.endo@dmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191210
PL  - Netherlands
TA  - Sci Bull (Beijing)
JT  - Science bulletin
JID - 101655530
SB  - IM
OTO - NOTNLM
OT  - Cathepsin C
OT  - Periapical periodontitis
OT  - Receptor activator of nuclear factor-kappaB ligand
OT  - Tartrate resistant acid phosphatase
COIS- Conflict of interest The authors declare that they have no conflict of interest.
EDAT- 2020/06/15 00:00
MHDA- 2020/06/15 00:01
CRDT- 2023/02/07 01:08
PHST- 2019/10/22 00:00 [received]
PHST- 2019/11/13 00:00 [revised]
PHST- 2019/11/20 00:00 [accepted]
PHST- 2023/02/07 01:08 [entrez]
PHST- 2020/06/15 00:00 [pubmed]
PHST- 2020/06/15 00:01 [medline]
AID - S2095-9273(19)30704-2 [pii]
AID - 10.1016/j.scib.2019.12.006 [doi]
PST - ppublish
SO  - Sci Bull (Beijing). 2020 Jun 15;65(11):951-957. doi: 10.1016/j.scib.2019.12.006. 
      Epub 2019 Dec 10.