PMID- 36747661
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240313
DP  - 2023 Jan 25
TI  - Electrophysiological signatures of visual recognition memory across all layers of 
      mouse V1.
LID - 2023.01.25.524429 [pii]
LID - 10.1101/2023.01.25.524429 [doi]
AB  - In mouse primary visual cortex (V1), familiar stimuli evoke significantly altered 
      responses when compared to novel stimuli. This stimulus-selective response 
      plasticity (SRP) was described originally as an increase in the magnitude of 
      visual evoked potentials (VEPs) elicited in layer (L) 4 by familiar 
      phase-reversing grating stimuli. SRP is dependent on NMDA receptors (NMDAR) and 
      has been hypothesized to reflect potentiation of thalamocortical synapses in L4. 
      However, recent evidence indicates that the synaptic modifications that manifest 
      as SRP do not occur on L4 principal cells. To shed light on where and how SRP is 
      induced and expressed, the present study had three related aims: (1) to confirm 
      that NMDAR are required specifically in glutamatergic principal neurons of V1, 
      (2) to investigate the consequences of deleting NMDAR specifically in L6, and (3) 
      to use translaminar electrophysiological recordings to characterize SRP 
      expression in different layers of V1. We find that knockout of NMDAR in L6 
      principal neurons disrupts SRP. Current-source density analysis of the VEP depth 
      profile shows augmentation of short latency current sinks in layers 3, 4 and 6 in 
      response to phase reversals of familiar stimuli. Multiunit recordings demonstrate 
      that increased peak firing occurs to in response to phase reversals of familiar 
      stimuli across all layers, but that activity between phase reversals is 
      suppressed. Together, these data reveal important aspects of the underlying 
      phenomenology of SRP and generate new hypotheses for the expression of 
      experience-dependent plasticity in V1. SIGNIFICANCE STATEMENT: Repeated exposure 
      to stimuli that portend neither reward nor punishment leads to behavioral 
      habituation, enabling organisms to dedicate attention to novel or otherwise 
      significant features of the environment. The neural basis of this process, which 
      is so often dysregulated in neurological and psychiatric disorders, remains 
      poorly understood. Learning and memory of stimulus familiarity can be studied in 
      mouse visual cortex by measuring electrophysiological responses to simple 
      phase-reversing grating stimuli. The current study advances knowledge of this 
      process by documenting changes in visual evoked potentials, neuronal spiking 
      activity, and oscillations in the local field potentials across all layers of 
      mouse visual cortex. In addition, we identify a key contribution of a specific 
      population of neurons in layer 6 of visual cortex.
FAU - Hayden, Dustin J
AU  - Hayden DJ
FAU - Finnie, Peter S B
AU  - Finnie PSB
AUID- ORCID: 0000-0003-2806-9600
FAU - Thomazeau, Aurore
AU  - Thomazeau A
AUID- ORCID: 0000-0002-7668-2867
FAU - Li, Alyssa Y
AU  - Li AY
FAU - Cooke, Samuel F
AU  - Cooke SF
AUID- ORCID: 0000-0002-4876-6502
FAU - Bear, Mark F
AU  - Bear MF
AUID- ORCID: 0000-0002-9903-2541
LA  - eng
GR  - MR/N026063/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/W006251/1/MRC_/Medical Research Council/United Kingdom
GR  - R01 EY023037/EY/NEI NIH HHS/United States
PT  - Preprint
DEP - 20230125
PL  - United States
TA  - bioRxiv
JT  - bioRxiv : the preprint server for biology
JID - 101680187
UIN - J Neurosci. 2023 Sep 15;:. PMID: 37714707
PMC - PMC9900851
EDAT- 2023/02/08 06:00
MHDA- 2023/02/08 06:01
PMCR- 2023/02/06
CRDT- 2023/02/07 01:56
PHST- 2023/02/07 01:56 [entrez]
PHST- 2023/02/08 06:00 [pubmed]
PHST- 2023/02/08 06:01 [medline]
PHST- 2023/02/06 00:00 [pmc-release]
AID - 2023.01.25.524429 [pii]
AID - 10.1101/2023.01.25.524429 [doi]
PST - epublish
SO  - bioRxiv [Preprint]. 2023 Jan 25:2023.01.25.524429. doi: 
      10.1101/2023.01.25.524429.