PMID- 36747994
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230208
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2023
DP  - 2023
TI  - Association between Intrapancreatic Fat Deposition and Lower High-Density 
      Lipoprotein Cholesterol in Individuals with Newly Diagnosed T2DM.
PG  - 6991633
LID - 10.1155/2023/6991633 [doi]
LID - 6991633
AB  - BACKGROUND: Intrapancreatic fat deposition (IPFD) usually occurs in individuals 
      with type 2 diabetes mellitus (T2DM), but its physiopathological influence 
      remains controversial. The present study aimed to investigate IPFD and its 
      associations with various aspects of glucose and lipid metabolism in individuals 
      with newly diagnosed T2DM. METHODS: A total of 100 individuals were included, 
      consisting of 80 patients with newly diagnosed T2DM and 20 age- and sex-matched 
      healthy controls. Then, we assessed IPFD using magnetic resonance imaging (MRI) 
      and various parameters of glucose and lipid metabolism. RESULTS: Individuals with 
      newly diagnosed T2DM had a significantly higher IPFD (median: 12.34%; IQR, 
      9.19-16.60%) compared with healthy controls (median: 6.35%; IQR, 5.12-8.96%) (p < 
      0.001). In individuals with newly diagnosed T2DM, IPFD was significantly 
      associated with FINS and HOMA-IR in unadjusted model (beta = 0.239, p=0.022; 
      beta = 0.578, p=0.007, respectively) and adjusted model for age and sex (beta = 0.241, 
      p=0.022; beta = 0.535, p=0.014, respectively), but these associations vanished after 
      adjustment for age, sex, and BMI. The OR of lower HDL-C for the prevalence of 
      high IPFD was 4.22 (95% CI, 1.41 to 12.69; p=0.010) after adjustment for age, 
      sex, BMI, and HbA1c. CONCLUSIONS: Lower HDL-C was an independent predictor for a 
      high degree of IPFD.
CI  - Copyright (c) 2023 Jianliang Wang et al.
FAU - Wang, Jianliang
AU  - Wang J
AUID- ORCID: 0000-0002-6290-4625
AD  - General Surgery Department, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing 100020, China.
FAU - Cai, Qingyun
AU  - Cai Q
AUID- ORCID: 0000-0003-4760-4699
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing 100020, China.
FAU - Wu, Xiaojuan
AU  - Wu X
AUID- ORCID: 0000-0002-7320-2354
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing 100020, China.
FAU - Wang, Jiaxuan
AU  - Wang J
AUID- ORCID: 0000-0003-2030-6683
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing 100020, China.
FAU - Chang, Xiaona
AU  - Chang X
AUID- ORCID: 0000-0002-1390-3896
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing 100020, China.
FAU - Ding, Xiaoyu
AU  - Ding X
AUID- ORCID: 0000-0001-8490-512X
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing 100020, China.
FAU - Liu, Jia
AU  - Liu J
AUID- ORCID: 0000-0002-6957-3814
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing 100020, China.
FAU - Wang, Guang
AU  - Wang G
AUID- ORCID: 0000-0001-9321-5200
AD  - Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical 
      University, Beijing 100020, China.
LA  - eng
PT  - Journal Article
DEP - 20230128
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC9899139
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2023/02/08 06:00
MHDA- 2023/02/08 06:01
PMCR- 2023/01/28
CRDT- 2023/02/07 02:03
PHST- 2022/11/12 00:00 [received]
PHST- 2023/01/15 00:00 [revised]
PHST- 2023/01/18 00:00 [accepted]
PHST- 2023/02/07 02:03 [entrez]
PHST- 2023/02/08 06:00 [pubmed]
PHST- 2023/02/08 06:01 [medline]
PHST- 2023/01/28 00:00 [pmc-release]
AID - 10.1155/2023/6991633 [doi]
PST - epublish
SO  - Int J Endocrinol. 2023 Jan 28;2023:6991633. doi: 10.1155/2023/6991633. 
      eCollection 2023.