PMID- 36749091
OWN - NLM
STAT- MEDLINE
DCOM- 20230213
LR  - 20230213
IS  - 2162-6537 (Electronic)
IS  - 0731-8898 (Linking)
VI  - 42
IP  - 2
DP  - 2023
TI  - Expression Profiles, Prognosis, and ceRNA Regulation of SRY-Related HMG-Box Genes 
      in Stomach Adenocarcinoma.
PG  - 79-91
LID - 10.1615/JEnvironPatholToxicolOncol.2022044640 [doi]
AB  - Aberrant expression of the SRY-related HMG-box (SOX) genes contributes to tumor 
      development and progression. This research aimed to identify the regulation of 
      the SOX genes in stomach adenocarcinoma (STAD). Expression profiles downloaded 
      from The Cancer Genome Atlas (TCGA) were conducted to analyze the expression and 
      function of the SOX genes. A competing endogenous RNAs (ceRNA) network mediated 
      by the SOX genes was effectively constructed consisting of 64 lncRNAs, 29 miRNAs, 
      and 11 SOX genes based on predicted miRNAs shared by lncRNAs and mRNAs using 
      miRDB, TargetScan, miRTarBase, miRcode, and starBase v2.0. SOX9 was identified as 
      a prognostic signature, which showed the usefulness of diagnosis and prognosis of 
      STAD by the receiver operating characteristic (ROC) and Kaplan-Meier curves. SOX9 
      was also shown specifically in STAD and identified as highly expressed in the 
      gastrointestinal tract. Gene Ontology (GO) enrichment analysis showed that SOX9 
      might influence the genes related to the pattern specification process, sodium 
      ion homeostasis, and potassium ion transport, mainly including FEZF1, HOXC13, 
      HOXC10, HOXC9, HOXA11, DPP6, ATP4B, CASQ2, KCNA1, ATP4A, and SFRP1. Furthermore, 
      HOTAIR knockdown, miR-206-mimic transfection, the Cell Count Kit-8 (CCK-8) assay 
      were performed to verify the function of HOTAIR/miR-206/SOX9 axis, which was 
      identified in the ceRNA network analysis. HOTAIR could induce proliferation 
      potentially by competitively binding miR-206/SOX9 axis in STAD. These findings 
      provide new clues with prognostic and therapeutic implications in STAD and 
      suggest that HOTAIR/miR-206/SOX9 might be a potential new strategy for 
      therapeutic targeting of gastric cancer.
FAU - Zhu, Chang
AU  - Zhu C
AD  - Department of Gastrointestinal Surgery, Shenzhen People's Hospital (The Second 
      Clinical Medical College, Jinan University; The First Affiliated Hospital, 
      Southern University of Science and Technology), Shenzhen 518020, China.
FAU - Fu, Yuxiang
AU  - Fu Y
AD  - Department of Gastrointestinal Surgery, Shenzhen People's Hospital (The Second 
      Clinical Medical College, Jinan University; The First Affiliated Hospital, 
      Southern University of Science and Technology), Shenzhen 518020, China.
FAU - Xia, Ligang
AU  - Xia L
AD  - Department of Gastrointestinal Surgery, Shenzhen People's Hospital (The Second 
      Clinical Medical College, Jinan University; The First Affiliated Hospital, 
      Southern University of Science and Technology), Shenzhen 518020, China.
FAU - Li, Fang
AU  - Li F
AD  - Department of Gastrointestinal Surgery, Shenzhen People's Hospital (The Second 
      Clinical Medical College, Jinan University; The First Affiliated Hospital, 
      Southern University of Science and Technology), Shenzhen 518020, China.
FAU - Huang, Kaibin
AU  - Huang K
AD  - Department of Gastrointestinal Surgery, Shenzhen People's Hospital (The Second 
      Clinical Medical College, Jinan University; The First Affiliated Hospital, 
      Southern University of Science and Technology), Shenzhen 518020, China.
FAU - Sun, Xiao
AU  - Sun X
AD  - Department of Gastrointestinal Surgery, Shenzhen People's Hospital (The Second 
      Clinical Medical College, Jinan University; The First Affiliated Hospital, 
      Southern University of Science and Technology), Shenzhen 518020, China.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Environ Pathol Toxicol Oncol
JT  - Journal of environmental pathology, toxicology and oncology : official organ of 
      the International Society for Environmental Toxicology and Cancer
JID - 8501420
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (HOXC10 protein, human)
RN  - 0 (MicroRNAs)
RN  - 0 (MIRN206 microRNA, human)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (SOX9 protein, human)
RN  - 0 (HOTAIR long untranslated RNA, human)
SB  - IM
MH  - Humans
MH  - *Adenocarcinoma/genetics
MH  - Biomarkers, Tumor/metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Gene Regulatory Networks
MH  - Homeodomain Proteins/genetics/metabolism
MH  - *MicroRNAs/genetics
MH  - *RNA, Long Noncoding/genetics
MH  - *Stomach Neoplasms/genetics
EDAT- 2023/02/08 06:00
MHDA- 2023/02/10 06:00
CRDT- 2023/02/07 09:04
PHST- 2023/02/07 09:04 [entrez]
PHST- 2023/02/08 06:00 [pubmed]
PHST- 2023/02/10 06:00 [medline]
AID - 2d384a7628bab924,6763025c38c95bca [pii]
AID - 10.1615/JEnvironPatholToxicolOncol.2022044640 [doi]
PST - ppublish
SO  - J Environ Pathol Toxicol Oncol. 2023;42(2):79-91. doi: 
      10.1615/JEnvironPatholToxicolOncol.2022044640.