PMID- 36749209
OWN - NLM
STAT- MEDLINE
DCOM- 20230412
LR  - 20230529
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Print)
IS  - 0033-8419 (Linking)
VI  - 307
IP  - 2
DP  - 2023 Apr
TI  - Postacute COVID-19 Syndrome: (129)Xe MRI Ventilation Defects and Respiratory 
      Outcomes 1 Year Later.
PG  - e222557
LID - 10.1148/radiol.222557 [doi]
LID - e222557
AB  - Background In individuals with postacute COVID-19 syndrome (PACS) and normal 
      pulmonary function, xenon 129 ((129)Xe) MRI ventilation defects, abnormal 
      quality-of-life scores, and exercise limitation were reported 3 months after 
      infection; the longitudinal trajectory remains unclear. Purpose To measure and 
      compare pulmonary function, exercise capacity, quality of life, and (129)Xe MRI 
      ventilation defect percent (VDP) in individuals with PACS evaluated 3 and 15 
      months after COVID-19 infection. Materials and Methods In this prospective study, 
      participants with PACS aged 18-80 years were enrolled between July 2020 and 
      August 2021 from two quaternary care centers. (129)Xe MRI VDP, diffusing capacity 
      of lung for carbon monoxide (Dlco), spirometry, oscillometry, 6-minute walk 
      distance (6MWD), and St George Respiratory Questionnaire (SGRQ) scores were 
      evaluated 3 months and 15 months after COVID-19 infection. Differences between 
      time points were evaluated using the paired t test. Multivariable models were 
      generated to explain exercise capacity and quality-of-life improvement. Odds 
      ratios (ORs) were used to evaluate potential treatment influences. Results 
      Overall, 53 participants (mean age, 55 years +/- 18 [SD]; 27 women) attended both 
      3- and 15-month visits and were included in the analysis. The mean values for 
      (129)Xe MRI VDP (5.8% and 4.2%; P = .003), forced expiratory volume in the 1st 
      second of expiration percent predicted (84% and 90%; P = .001), Dlco percent 
      predicted (86% and 99%; P = .002), and SGRQ score (35 and 25; P < .001) improved 
      between the 3- and 15-month visit. VDP measured 3 months after COVID-19 infection 
      predicted the change in 6MWD (beta = -0.643, P = .006), while treatment with 
      respiratory medication at 3 months predicted an improved quality-of-life score at 
      15 months (OR, 4.0; 95% CI: 1.2, 13.8; P = .03). Conclusion Pulmonary function, 
      gas exchange, exercise capacity, quality of life, and (129)Xe MRI ventilation 
      defect percent (VDP) improved in participants with postacute COVID-19 syndrome at 
      15 months compared with 3 months after infection. VDP measured at 3 months after 
      infection correlated with improved exercise capacity, while treatment with 
      respiratory medication was associated with an improved quality-of-life score 15 
      months after infection. ClinicalTrials.gov registration no. NCT05014516 (c) RSNA, 
      2023 Supplemental material is available for this article. See also the editorial 
      by Vogel-Claussen in this issue.
FAU - Kooner, Harkiran K
AU  - Kooner HK
AUID- ORCID: 0000-0003-4040-4977
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - McIntosh, Marrissa J
AU  - McIntosh MJ
AUID- ORCID: 0000-0003-2678-458X
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Matheson, Alexander M
AU  - Matheson AM
AUID- ORCID: 0000-0002-6022-9507
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Abdelrazek, Mohammed
AU  - Abdelrazek M
AUID- ORCID: 0000-0001-5626-8223
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Albert, Mitchell S
AU  - Albert MS
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Dhaliwal, Inderdeep
AU  - Dhaliwal I
AUID- ORCID: 0000-0003-1795-3855
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Kirby, Miranda
AU  - Kirby M
AUID- ORCID: 0000-0003-2951-784X
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Ouriadov, Alexei
AU  - Ouriadov A
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Santyr, Giles E
AU  - Santyr GE
AUID- ORCID: 0000-0001-7396-188X
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Venegas, Carmen
AU  - Venegas C
AUID- ORCID: 0000-0002-1060-6503
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Radadia, Nisarg
AU  - Radadia N
AUID- ORCID: 0000-0002-4872-1443
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Svenningsen, Sarah
AU  - Svenningsen S
AUID- ORCID: 0000-0002-6225-1863
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Nicholson, J Michael
AU  - Nicholson JM
AUID- ORCID: 0000-0003-1560-7967
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
FAU - Parraga, Grace
AU  - Parraga G
AUID- ORCID: 0000-0002-5619-4145
AD  - From the Robarts Research Institute (H.K.K., M.J.M., A.M.M., G.P.), Department of 
      Medical Biophysics (H.K.K., M.J.M., A.M.M., G.P.), Department of Medical Imaging 
      (M.A., G.P.), Division of Respirology, Department of Medicine (I.D., J.M.N., 
      G.P.), and Department of Physics and Astronomy (A.O.), Western University, 1151 
      Richmond St N, London, ON, Canada N6A 5B7; Department of Chemistry, Lakehead 
      University, Thunder Bay, Canada (M.S.A.); Department of Physics, Toronto 
      Metropolitan University, Toronto, Canada (M.K.); Translational Medicine Program, 
      Hospital for Sick Children, Toronto, Canada (G.E.S.); and Division of 
      Respirology, Department of Medicine, McMaster University and Firestone Institute 
      for Respiratory Health, St Joseph's Health Care, Hamilton, Canada (C.V., N.R., 
      S.S.).
LA  - eng
SI  - ClinicalTrials.gov/NCT05014516
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230207
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2023 Feb 7;:230113. PMID: 36749215
CIN - Radiology. 2023 May;307(4):e230479. PMID: 37070997
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - *COVID-19
MH  - Lung
MH  - Magnetic Resonance Imaging/methods
MH  - Prospective Studies
MH  - Quality of Life
MH  - *Respiration Disorders
MH  - Adolescent
MH  - Aged
MH  - Aged, 80 and over
MH  - Male
PMC - PMC9926501
COIS- Disclosures of conflicts of interest: H.K.K. No relevant relationships. M.J.M. No 
      relevant relationships. A.M.M. No relevant relationships. M.A. No relevant 
      relationships. M.S.A. No relevant relationships. I.D. No relevant relationships. 
      M.K. Consultant for VIDA Diagnostics. A.O. No relevant relationships. G.E.S. No 
      relevant relationships. C.V. Lecture honoraria from AstraZeneca and GSK; 
      conference travel support from AstraZeneca. N.R. No relevant relationships. S.S. 
      Lecture honoraria from Polarean. J.M.N. Lecture honoraria from AstraZeneca, 
      Vertex, Valeo Pharma, and Horizon Therapeutics. G.P. Grant from Ontario Rapid 
      Response; consulting fees from Polarean Imaging; payment or honoraria from 
      AstraZeneca; member of the Institute Advisory Board, Institute of Circulatory and 
      Respiratory Health, and Canadian Institutes of Health Research; member of the 
      RSNA Thoracic Imaging board of directors.
EDAT- 2023/02/08 06:00
MHDA- 2023/04/12 06:42
PMCR- 2023/02/07
CRDT- 2023/02/07 10:06
PHST- 2023/04/12 06:42 [medline]
PHST- 2023/02/08 06:00 [pubmed]
PHST- 2023/02/07 10:06 [entrez]
PHST- 2023/02/07 00:00 [pmc-release]
AID - 10.1148/radiol.222557 [doi]
PST - ppublish
SO  - Radiology. 2023 Apr;307(2):e222557. doi: 10.1148/radiol.222557. Epub 2023 Feb 7.