PMID- 36749235
OWN - NLM
STAT- MEDLINE
DCOM- 20230211
LR  - 20230211
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 102
IP  - 5
DP  - 2023 Feb 3
TI  - The clinical efficacy of a mixture of ivy leaf extract and coptidis rhizome in 
      patients with idiopathic pulmonary fibrosis.
PG  - e32786
LID - 10.1097/MD.0000000000032786 [doi]
LID - e32786
AB  - Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with 
      poor prognosis and cough is the one of most common and major symptoms in IPF. The 
      aim of this study was to evaluate the clinical efficacy of a Mixture of Ivy Leaf 
      Extract and Coptidis rhizome (Synatura(R)) in patients with IPF. This was a 
      prospective, open-label, single-center, and single-arm study in Korea from 
      October 2019 to September 2020. IPF patients with chronic bronchitis were 
      enrolled. Between baseline and eight weeks after use of Synatura(R), clinical 
      measures regarding cough and health-related quality of life, and the systemic 
      inflammatory markers was prospectively collected. Thirty patients were enrolled. 
      Median age was 73 years and 86.7% were men. The median gender-age-pulmonary 
      function stage of IPF was 3. Baseline total score of Leicester cough 
      questionnaire (LCQ) and St. George respiratory questionnaire (SGRQ) were 104.5 
      and 30.59 respectively. After eight weeks, there was no significant improvement 
      in LCQ (16.8 [15.6-19.1] vs 17.5 [15.2-18.9], P = .772) and SGRQ (30.6 
      [19.4-37.8] vs 29.9 [19.6-41.8], P = .194) scores. Also, there was no significant 
      difference of systemic inflammatory markers. In analysis of minimal clinically 
      important differences (MCID), one third (33.3%) patients fulfilled the criteria 
      of MCID (1.3) in LCQ scores and median differences was 14 (range: 10-18). In 
      terms of SGRQ, 6 patients (20%) reached MCID (4.0) without significant predictive 
      factors. In our study, use of Synatura(R) during 8 weeks improved cough-specific 
      life quality in one third patients with IPF. Large-scale, randomized, 
      double-blind, and placebo-controlled clinical trials are needed.
CI  - Copyright (c) 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Lee, Jae Ha
AU  - Lee JH
AUID- ORCID: 0000-0003-0932-2826
AD  - Division of Pulmonology, Department of Internal Medicine, Inje University 
      Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of 
      Korea.
FAU - Jang, Ji Hoon
AU  - Jang JH
AD  - Division of Pulmonology, Department of Internal Medicine, Inje University 
      Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of 
      Korea.
FAU - Park, Jin Han
AU  - Park JH
AD  - Division of Pulmonology, Department of Internal Medicine, Inje University 
      Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of 
      Korea.
FAU - Jung, So Young
AU  - Jung SY
AD  - Division of Dermatology, Inje University Haeundae Paik Hospital, Inje University 
      College of Medicine, Busan, Republic of Korea.
FAU - Lee, Sunggun
AU  - Lee S
AD  - Division of Rheumatology, Department of Internal Medicine, Inje University 
      Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of 
      Korea.
FAU - Kim, Seong-Ho
AU  - Kim SH
AD  - Division of Rheumatology, Department of Internal Medicine, Inje University 
      Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of 
      Korea.
FAU - Kim, Ji Yeon
AU  - Kim JY
AD  - Division of Pathology, Inje University Haeundae Paik Hospital, Inje University 
      College of Medicine, Busan, Republic of Korea.
FAU - Ko, Junghae
AU  - Ko J
AD  - Division of Endocrinology, Department of Internal Medicine, Inje University 
      Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of 
      Korea.
FAU - Choi, Hee Eun
AU  - Choi HE
AD  - Department of Physical Medicine and Rehabilitation, Inje University Haeundae Paik 
      Hospital, Inje University College of Medicine, Busan, Republic of Korea.
FAU - No, Tae-Hoon
AU  - No TH
AD  - Department of Infectious Diseases, Inje University Haeundae Paik Hospital, Inje 
      University College of Medicine, Busan, Republic of Korea.
FAU - Jang, Hang-Jea
AU  - Jang HJ
AD  - Division of Pulmonology, Department of Internal Medicine, Inje University 
      Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of 
      Korea.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - *Cough/drug therapy
MH  - *Idiopathic Pulmonary Fibrosis/drug therapy
MH  - Prospective Studies
MH  - Quality of Life
MH  - Rhizome
MH  - Treatment Outcome
PMC - PMC9901986
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2023/02/08 06:00
MHDA- 2023/02/10 06:00
PMCR- 2023/02/03
CRDT- 2023/02/07 10:06
PHST- 2023/02/08 06:00 [pubmed]
PHST- 2023/02/10 06:00 [medline]
PHST- 2023/02/07 10:06 [entrez]
PHST- 2023/02/03 00:00 [pmc-release]
AID - 00005792-202302030-00015 [pii]
AID - 10.1097/MD.0000000000032786 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2023 Feb 3;102(5):e32786. doi: 10.1097/MD.0000000000032786.