PMID- 36750172
OWN - NLM
STAT- MEDLINE
DCOM- 20230223
LR  - 20230301
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 15
IP  - 3
DP  - 2023 Feb 6
TI  - Intrinsic capacity differs from functional ability in predicting 10-year 
      mortality and biological features in healthy aging: results from the I-Lan 
      longitudinal aging study.
PG  - 748-764
LID - 10.18632/aging.204508 [doi]
AB  - This study aimed to explore the biological features and mortality risk of 
      intrinsic capacity (IC) and functional ability (FA). Based on data from 1839 
      participants from the I-Lan Longitudinal Aging Study, multivariable Cox 
      proportional hazard models were used to evaluate the predictive ability of IC 
      (range 0-100) and FA (range 0-100) on 10-year mortality. Of 2038 repeated 
      measurements for IC within a 7-year observational period, multivariable logistic 
      regression was used to compare biological features of participants with 
      maintained, improved and rapidly deteriorated IC. A 1-point increased IC value 
      was associated with a 5% (HR 0.95, 95% CI 0.93-0.97, p < 0.001) decrease in 
      mortality risk. Low IC (HR 1.94, 95% CI 1.39-2.70, p < 0.001) was associated with 
      higher mortality risk. Hyperglycemia (OR 1.40, 95% CI 1.09-1.81, p = 0.010), low 
      serum levels of DHEA-S (OR 3.33, 95% CI 1.32-8.41, p = 0.011), and high serum 
      levels of C-reactive protein (OR 1.45, 95% CI 1.05-2.00, p = 0.023) were 
      associated with low IC at baseline. Low serum levels of DHEA-S (middle tertile OR 
      1.84, 95% CI 1.15-2.95, p = 0.012; lowest tertile OR 2.25, 95% CI 1.34-3.77, p = 
      0.002) and vitamin D deficiency (OR 1.82, 95% CI 1.02-3.27, p = 0.044) were 
      associated with rapid deterioration of IC. IC and FA predicted 10-year mortality, 
      whereas chronic inflammation, hyperglycemia, and low DHEA-S were associated with 
      low IC status. Low DHEA-S and vitamin D deficiency may be considered as potential 
      biomarkers of rapid IC declines, which implies underlying biological mechanisms 
      of healthy aging.
FAU - Lee, Wei-Ju
AU  - Lee WJ
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Department of Geriatric Medicine, National Yang Ming Chiao Tung University, 
      School of Medicine, Taipei, Taiwan.
AD  - Department of Family Medicine, Taipei Veterans General Hospital Yuanshan Branch, 
      Yi-Lan County, Taiwan.
FAU - Peng, Li-Ning
AU  - Peng LN
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Department of Geriatric Medicine, National Yang Ming Chiao Tung University, 
      School of Medicine, Taipei, Taiwan.
AD  - Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, 
      Taiwan.
FAU - Lin, Ming-Hsien
AU  - Lin MH
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Department of Geriatric Medicine, National Yang Ming Chiao Tung University, 
      School of Medicine, Taipei, Taiwan.
AD  - Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, 
      Taiwan.
FAU - Loh, Ching-Hui
AU  - Loh CH
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Department of Geriatric Medicine, National Yang Ming Chiao Tung University, 
      School of Medicine, Taipei, Taiwan.
AD  - Center of Health and Aging, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical 
      Foundation, Hualien County, Taiwan.
FAU - Hsiao, Fei-Yuan
AU  - Hsiao FY
AD  - Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
AD  - School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 
      Taiwan.
AD  - Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan.
FAU - Chen, Liang-Kung
AU  - Chen LK
AD  - Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung 
      University, Taipei, Taiwan.
AD  - Department of Geriatric Medicine, National Yang Ming Chiao Tung University, 
      School of Medicine, Taipei, Taiwan.
AD  - Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, 
      Taiwan.
AD  - Taipei Municipal Gan-Dau Hospital, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230206
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 459AG36T1B (Dehydroepiandrosterone)
SB  - IM
MH  - Humans
MH  - *Healthy Aging
MH  - Longitudinal Studies
MH  - Aging
MH  - Dehydroepiandrosterone
MH  - *Vitamin D Deficiency
PMC - PMC9970311
OTO - NOTNLM
OT  - biomarkers
OT  - functional ability
OT  - healthy aging
OT  - intrinsic capacity
OT  - mortality
COIS- CONFLICTS OF INTEREST: The authors declare no conflicts of interest related to 
      this study.
EDAT- 2023/02/08 06:00
MHDA- 2023/02/25 06:00
PMCR- 2023/02/14
CRDT- 2023/02/07 19:12
PHST- 2022/07/28 00:00 [received]
PHST- 2023/01/23 00:00 [accepted]
PHST- 2023/02/08 06:00 [pubmed]
PHST- 2023/02/25 06:00 [medline]
PHST- 2023/02/07 19:12 [entrez]
PHST- 2023/02/14 00:00 [pmc-release]
AID - 204508 [pii]
AID - 10.18632/aging.204508 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2023 Feb 6;15(3):748-764. doi: 10.18632/aging.204508. Epub 
      2023 Feb 6.