PMID- 36750271
OWN - NLM
STAT- MEDLINE
DCOM- 20230602
LR  - 20230610
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Print)
IS  - 2233-6079 (Linking)
VI  - 47
IP  - 3
DP  - 2023 May
TI  - Gestational Diabetes Mellitus and Its Implications across the Life Span.
PG  - 333-344
LID - 10.4093/dmj.2022.0348 [doi]
AB  - Gestational diabetes mellitus (GDM) has historically been perceived as a medical 
      complication of pregnancy that also serves as a harbinger of maternal risk of 
      developing type 2 diabetes mellitus (T2DM) in the future. In recent decades, a 
      growing body of evidence has detailed additional lifelong implications that 
      extend beyond T2DM, including an elevated risk of ultimately developing 
      cardiovascular disease. Furthermore, the risk factors that mediate this lifetime 
      cardiovascular risk are evident not only after delivery but are present even 
      before the pregnancy in which GDM is first diagnosed. The concept thus emerging 
      from these data is that the diagnosis of GDM enables the identification of women 
      who are already on an enhanced track of cardiometabolic risk that starts early in 
      life. Studies of the offspring of pregnancies complicated by diabetes now suggest 
      that the earliest underpinnings of this cardiometabolic risk profile may be 
      determined in utero and may first manifest clinically in childhood. Accordingly, 
      from this perspective, GDM is now seen as a chronic metabolic disorder that holds 
      implications across the life span of both mother and child.
FAU - Wicklow, Brandy
AU  - Wicklow B
AD  - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, 
      Canada.
AD  - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.
FAU - Retnakaran, Ravi
AU  - Retnakaran R
AD  - Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada.
AD  - Division of Endocrinology, University of Toronto, Toronto, ON, Canada.
AD  - Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, 
      Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230208
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
SB  - IM
MH  - Pregnancy
MH  - Child
MH  - Humans
MH  - Female
MH  - *Diabetes, Gestational/epidemiology/diagnosis
MH  - *Diabetes Mellitus, Type 2/epidemiology/etiology
MH  - Longevity
MH  - Risk Factors
MH  - *Cardiovascular Diseases/etiology/complications
PMC - PMC10244196
OTO - NOTNLM
OT  - Cardiovascular diseases
OT  - Child
OT  - Diabetes, gestational
OT  - Life change events
COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2023/02/08 06:00
MHDA- 2023/06/02 06:42
PMCR- 2023/05/01
CRDT- 2023/02/07 20:45
PHST- 2022/10/07 00:00 [received]
PHST- 2022/11/13 00:00 [accepted]
PHST- 2023/06/02 06:42 [medline]
PHST- 2023/02/08 06:00 [pubmed]
PHST- 2023/02/07 20:45 [entrez]
PHST- 2023/05/01 00:00 [pmc-release]
AID - dmj.2022.0348 [pii]
AID - dmj-2022-0348 [pii]
AID - 10.4093/dmj.2022.0348 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2023 May;47(3):333-344. doi: 10.4093/dmj.2022.0348. Epub 2023 
      Feb 8.