PMID- 36750382
OWN - NLM
STAT- Publisher
LR  - 20240216
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
DP  - 2023 Feb 7
TI  - Bisphosphonate-Modified Functional Supramolecular Hydrogel Promotes Periodontal 
      Bone Regeneration by Osteoclast Inhibition.
LID - 10.1021/acsami.2c21297 [doi]
AB  - Regeneration of periodontal tissue remains a challenge. Under periodontitis, 
      osteoclasts are overactivated and bone loss occurs. We incorporated sodium 
      alendronate (Alen), a medication commonly used to treat osteoporosis, into a 
      supramolecular hydrogel system in order to create a novel biomaterial that would 
      promote periodontal bone regeneration by inhibiting osteoclast overactivation. 
      The Nap-Gly-Phe-Phe (NapGFF) peptide chain was modified to synthesize the 
      functional Nap-Alen gelator. Afterward, the Nap-Alen/HAP supramolecular hydrogel 
      composite with a suitable hydroxyapatite (HAP) ratio was constructed, which has 
      outstanding mechanical properties and 3D structure. In addition to its good 
      biocompatibility, it can inhibit the proliferation of bone marrow-derived 
      macrophages (BMDMs) and differentiation of osteoclasts. Due to the simultaneous 
      introduction of porous HAP, the hydrogel with a nanofiber structure was formed 
      into a 3D mesh-like sparse porous composite hydrogel. While enhancing the 
      mechanical properties of the gel, the porous structure facilitated the attachment 
      and migration of bone regeneration-related cells. Therefore, it can effectively 
      promote the regeneration of periodontal bone. In the future, by modifying the 
      biophysical properties and loading stem cells or cytokines, this supramolecular 
      hydrogel composite constructed in this study may provide a new strategy for 
      tissue regeneration engineering and provide a preliminary experimental basis for 
      relevant clinical translational studies.
FAU - Hu, Cheng
AU  - Hu C
AD  - Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
AD  - Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Zhang, Mei
AU  - Zhang M
AD  - Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
AD  - Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Wu, Jin
AU  - Wu J
AD  - Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
AD  - Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Cao, Xing
AU  - Cao X
AD  - Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
AD  - Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Chen, Luxian
AU  - Chen L
AD  - Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
AD  - Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Yan, Jiayin
AU  - Yan J
AD  - Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
AD  - Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China.
FAU - Liang, Gaolin
AU  - Liang G
AD  - State Key Laboratory of Bioelectronics, School of Biological Science and Medical 
      Engineering, Southeast University, Nanjing, Jiangsu 210096, China.
FAU - Tan, Jiali
AU  - Tan J
AUID- ORCID: 0000-0001-8176-8318
AD  - Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China.
AD  - Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
AD  - Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510080, China.
LA  - eng
PT  - Journal Article
DEP - 20230207
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
SB  - IM
OTO - NOTNLM
OT  - bisphosphonate
OT  - hydroxyapatite
OT  - mononuclear macrophage
OT  - periodontal bone regeneration
OT  - periodontitis
OT  - supramolecular hydrogel
EDAT- 2023/02/08 06:00
MHDA- 2023/02/08 06:00
CRDT- 2023/02/07 21:42
PHST- 2023/02/07 21:42 [entrez]
PHST- 2023/02/08 06:00 [pubmed]
PHST- 2023/02/08 06:00 [medline]
AID - 10.1021/acsami.2c21297 [doi]
PST - aheadofprint
SO  - ACS Appl Mater Interfaces. 2023 Feb 7. doi: 10.1021/acsami.2c21297.