PMID- 36751175
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230209
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 1
DP  - 2023 Jan
TI  - Effects of Non-surgical Periodontal Therapy on Saliva and Gingival Crevicular 
      Fluid Levels of Chemerin in Periodontitis Subjects With and Without Type 2 
      Diabetes Mellitus.
PG  - e33388
LID - 10.7759/cureus.33388 [doi]
LID - e33388
AB  - Background Evidence had shown a bi-directional link between diabetes mellitus and 
      periodontitis. Chemerin, an adipose tissue-specific adipokine plays a significant 
      role in adipocyte initiation and differentiation that directly influences glucose 
      metabolism, lipid metabolism, and inflammatory mediators. Non-surgical 
      periodontal therapy (NSPT) for patients with periodontitis and diabetes mellitus 
      improves the periodontal condition and regulates glycemic level. Aims and 
      objectives To assess the impact of chemerin on periodontal disease and diabetes 
      mellitus pathogenesis and to analyze the impact of NSPT on saliva and gingival 
      crevicular fluid (GCF) chemerin levels in patients with periodontitis with and 
      without type 2 diabetes mellitus (T2DM). Materials and methods A total of 60 
      patients were divided into four groups: Group I: Systemically and periodontally 
      healthy subjects (n=15), Group II: Systemically healthy subjects with 
      periodontitis (n=15), Group III: Subjects with periodontitis and T2DM (n=15), 
      Group IV: Periodontally healthy subjects with T2DM (n=15). Indices and parameters 
      like plaque index (PI), gingival index (GI), periodontal probing depth (PPD), and 
      clinical attachment level (CAL) were assessed at baseline in all four groups and 
      six weeks after NSPT in Group II and Group III. A glycated hemoglobin (HbA1c) 
      test was taken to assess the patient's blood glucose level. Fasting blood sugar 
      (FBS) level was taken at baseline in all the groups and six weeks after NSPT in 
      Group II and Group III subjects. Saliva and GCF chemerin levels were assessed at 
      baseline in all four groups and six weeks after NSPT in Group II and Group III 
      subjects. Results A statistically significant difference was observed in 
      comparing chemerin levels at baseline with all four groups (p < 0.001). After 
      NSPT, there was a reduction in clinical parameters, FBS, and chemerin levels in 
      Group II and Group III. A positive correlation was observed between salivary 
      chemerin and FBS in Group II, GCF chemerin, PI, and FBS in Group II, and PPD and 
      FBS in Group III. A negative correlation was observed between salivary chemerin 
      and all parameters in Group II and between salivary chemerin and GCF chemerin in 
      Group III. Conclusion Based on the observed relationship between chemerin and the 
      parameters, their utility as a dual biomarker for diagnosis and prognosis in 
      periodontal disease seems promising. However, further studies with a larger 
      sample size on the role of chemerin in health and various states of diseases are 
      required to substantiate the result of the study.
CI  - Copyright (c) 2023, GD et al.
FAU - Gd, Gomathi
AU  - Gd G
AD  - Periodontics, Priyadarshini Dental College & Hospital, Chennai, IND.
FAU - S, Gopalakrishnan
AU  - S G
AD  - Periodontology, Thai Moogambigai Dental College and Hospital, Dr MGR Educational 
      and Research Institute, Chennai, IND.
FAU - Sudhakar, Uma
AU  - Sudhakar U
AD  - Periodontics, Thai Moogambigai Dental College and Hospital, Chennai, IND.
FAU - Raghavan, Anusha
AU  - Raghavan A
AD  - Public Health Dentistry, Ragas Dental College and Hospital, Chennai, IND.
FAU - Narayan, Keerthi V
AU  - Narayan KV
AD  - Oral and Maxillofacial Pathology, Dr MGR Educational and Research Institute, 
      Chennai, IND.
LA  - eng
PT  - Journal Article
DEP - 20230105
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC9899038
OTO - NOTNLM
OT  - chemerin
OT  - gingival crevicular fluid (gcf)
OT  - periodontitis
OT  - scaling and root planing
OT  - type 2 diabetes mellites
OT  - unstimulated saliva
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/02/09 06:00
MHDA- 2023/02/09 06:01
PMCR- 2023/01/05
CRDT- 2023/02/08 01:53
PHST- 2023/01/05 00:00 [accepted]
PHST- 2023/02/08 01:53 [entrez]
PHST- 2023/02/09 06:00 [pubmed]
PHST- 2023/02/09 06:01 [medline]
PHST- 2023/01/05 00:00 [pmc-release]
AID - 10.7759/cureus.33388 [doi]
PST - epublish
SO  - Cureus. 2023 Jan 5;15(1):e33388. doi: 10.7759/cureus.33388. eCollection 2023 Jan.