PMID- 36751361
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230209
IS  - 1751-1437 (Print)
IS  - 2057-360X (Electronic)
IS  - 1751-1437 (Linking)
VI  - 23
IP  - 4
DP  - 2022 Nov
TI  - Right ventricular function is associated with 28-day mortality in myocardial 
      infarction complicated by cardiogenic shock: A retrospective observational study.
PG  - 439-446
LID - 10.1177/17511437211037927 [doi]
AB  - BACKGROUND: Right ventricular (RV) function is increasingly being recognised as 
      an important factor influencing outcomes in ST elevation myocardial infarction 
      (STEMI) complicated by cardiogenic shock (CS). In this study, we investigated RV 
      echocardiographic parameters' association with 28-day mortality in patients 
      admitted to intensive care with STEMI complicated by CS with reduced left 
      ventricle ejection fraction (LVEF). METHOD: We performed a retrospective analysis 
      of patients admitted to intensive care unit (ICU) in a single tertiary cardiac 
      centre over a 34-month period with STEMI complicated by CS and LVEF < 40%. 
      Clinical and echocardiographic data were collected and correlated with 28-day 
      mortality. RESULTS: One-hundred patients were included with a mean age of 62.6 
      +/-12.7 years and 78% were male. Mortality at 28 days was 37%. Respectively, 85%, 
      40% and 25% of patients required mechanical ventilation, mechanical circulatory 
      support and renal replacement therapy. Tricuspid annulus peak systolic velocity 
      (RV S') was significantly higher in survivors (12 +/- 3.3 v 10 +/- 3.5 cm/s, p = 
      0.03) and was an independent predictor of mortality (odds ratio 1.2, 95% 
      confidence interval 1.1-1.4, p = 0.04). RV S' of 10.5 cm/s exhibited best 
      sensitivity and specificity (64% and 65%, respectively; p = 0.02) for mortality. 
      The Kaplan-Meier curve demonstrated 85% risk of 28-day mortality for RV S' < 
      10.5 cm/s v 53% for RV S' > 10.5 cm/s (p = 0.02). CONCLUSION: RV function is 
      associated 28-day mortality in patients admitted to ICU with STEMI complicated by 
      CS with reduced LVEF. RV S' predicted mortality with good sensitivity and 
      specificity.
CI  - (c) The Intensive Care Society 2021.
FAU - Lashin, Hazem
AU  - Lashin H
AUID- ORCID: 0000-0002-5630-3065
AD  - Adult Critical Care Unit, Barts Heart Centre, St Bartholomew's Hospital, West 
      Smithfield, London, UK. RINGGOLD: 560754
AD  - William Harvey Research Institute, Barts and the London school of medicine and 
      dentistry, Queen Mary University of London, Charterhouse square, London, UK. 
      RINGGOLD: 4617
FAU - Olusanya, Olusegun
AU  - Olusanya O
AD  - Adult Critical Care Unit, Barts Heart Centre, St Bartholomew's Hospital, West 
      Smithfield, London, UK. RINGGOLD: 560754
FAU - Bhattacharyya, Sanjeev
AU  - Bhattacharyya S
AD  - William Harvey Research Institute, Barts and the London school of medicine and 
      dentistry, Queen Mary University of London, Charterhouse square, London, UK. 
      RINGGOLD: 4617
AD  - Cardiology Department Barts Heart Centre, St Bartholomew's Hospital, West 
      Smithfield, London, UK. RINGGOLD: 560754
LA  - eng
PT  - Journal Article
DEP - 20210916
PL  - England
TA  - J Intensive Care Soc
JT  - Journal of the Intensive Care Society
JID - 101538668
PMC - PMC9679897
OTO - NOTNLM
OT  - Right ventricle
OT  - cardiogenic shock
OT  - echocardiography
OT  - myocardial infarction
COIS- The author(s) declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2023/02/09 06:00
MHDA- 2023/02/09 06:01
PMCR- 2021/09/16
CRDT- 2023/02/08 01:55
PHST- 2023/02/08 01:55 [entrez]
PHST- 2023/02/09 06:00 [pubmed]
PHST- 2023/02/09 06:01 [medline]
PHST- 2021/09/16 00:00 [pmc-release]
AID - 10.1177_17511437211037927 [pii]
AID - 10.1177/17511437211037927 [doi]
PST - ppublish
SO  - J Intensive Care Soc. 2022 Nov;23(4):439-446. doi: 10.1177/17511437211037927. 
      Epub 2021 Sep 16.