PMID- 36754192 OWN - NLM STAT- MEDLINE DCOM- 20230314 LR - 20230314 IS - 1873-3492 (Electronic) IS - 0009-8981 (Linking) VI - 541 DP - 2023 Feb 15 TI - Reference intervals for thyroid hormone, sex hormone, and clinical biochemical tests in cord blood from Taiwanese newborn - TMICS cohort. PG - 117247 LID - S0009-8981(23)00049-9 [pii] LID - 10.1016/j.cca.2023.117247 [doi] AB - BACKGROUND/PURPOSE: This study aims to establish reference intervals for important biochemical parameters in cord blood of newborn male and female infants in Taiwan and to investigate their sex difference. We also examined the correlation of the same markers between maternal blood levels and neonatal cord blood levels. METHODS: 2,136 pregnant women receiving regular routine prenatal health assessments in their third trimester (weeks 29-40) were recruited from nine hospitals in Taiwan between 2012 and 2015. After exclusion, we were left with 580 cord blood samples to include in this study. RESULTS: Cord blood thyroid-stimulating hormone was higher in males than females (p < 0.05). Males also had significantly higher sex hormone levels (estradiol, follicle-stimulating hormone, and sex hormone-binding globulin), while females had higher levels of luteinizing hormone. Male newborns had higher cord blood immunoglobulin E (IgE), while females had higher insulin-like growth factor-1 (IGF-1) levels. We found a slight positive link between maternal blood and cord blood in thyroid hormones and sex hormones. CONCLUSION: This study found sex differences in cord blood thyroid hormone, sex hormone, IGF-1, and IgE levels and a link between maternal blood levels of thyroid and sex hormones and those in the cord blood of their infants. CI - Copyright (c) 2023 Elsevier B.V. All rights reserved. FAU - Chen, Hui-Ming AU - Chen HM AD - Department of Family Medicine and Occupational Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. Electronic address: rayne336@cgmh.org.tw. FAU - Chen, Chou-Cheng AU - Chen CC AD - Department of Business Administration, CTBC Business School, Tainan, Taiwan. Electronic address: new.purple@ctbc.edu.tw. FAU - Chen, Jia-Jen AU - Chen JJ AD - Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Wu, Chia-Fang AU - Wu CF AD - Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Lee, Sih-Syuan AU - Lee SS AD - Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Kuo, Fu-Chen AU - Kuo FC AD - School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan; Department of Obstetrics & Gynecology, E-Da Hospital, Kaohsiung, Taiwan. Electronic address: ed100418@edah.org.tw. FAU - Sun, Chien-Wen AU - Sun CW AD - National Environmental Health Research Center, National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan. Electronic address: agnes@nhri.org.tw. FAU - Chen, Mei-Lien AU - Chen ML AD - Institute of Environmental and Occupational Health Sciences, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: mlchen@ym.edu.tw. FAU - Hsieh, Chia-Jung AU - Hsieh CJ AD - Department of Public Health, Tzu Chi University, Hualien, Taiwan. Electronic address: cjhsieh@mail.tcu.edu.tw. FAU - Wang, Shu-Li AU - Wang SL AD - National Environmental Health Research Center, National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; School of Public Health, National Defense Medical Center, Taipei, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan. Electronic address: slwang@nhri.org.tw. FAU - Wu, Ming-Tsang AU - Wu MT AD - Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; PhD Program in Environmental and Occupational Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: 960021@cc.kmuh.org.tw. LA - eng PT - Journal Article DEP - 20230206 PL - Netherlands TA - Clin Chim Acta JT - Clinica chimica acta; international journal of clinical chemistry JID - 1302422 RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 0 (Thyroid Hormones) RN - 0 (Gonadal Steroid Hormones) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Female MH - Pregnancy MH - Male MH - Infant, Newborn MH - Humans MH - *Insulin-Like Growth Factor I MH - *Fetal Blood MH - Thyroid Hormones MH - Gonadal Steroid Hormones MH - Immunoglobulin E OTO - NOTNLM OT - Cord blood OT - Pregnancy OT - Reference interval OT - Reference value OT - Third trimester COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/02/09 06:00 MHDA- 2023/03/15 06:00 CRDT- 2023/02/08 19:24 PHST- 2022/08/08 00:00 [received] PHST- 2023/02/03 00:00 [revised] PHST- 2023/02/03 00:00 [accepted] PHST- 2023/02/09 06:00 [pubmed] PHST- 2023/03/15 06:00 [medline] PHST- 2023/02/08 19:24 [entrez] AID - S0009-8981(23)00049-9 [pii] AID - 10.1016/j.cca.2023.117247 [doi] PST - ppublish SO - Clin Chim Acta. 2023 Feb 15;541:117247. doi: 10.1016/j.cca.2023.117247. Epub 2023 Feb 6.