PMID- 36755928 OWN - NLM STAT- MEDLINE DCOM- 20230211 LR - 20240322 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 14 DP - 2023 TI - The effects of three different low-volume aerobic training protocols on cardiometabolic parameters of type 2 diabetes patients: A randomized clinical trial. PG - 985404 LID - 10.3389/fendo.2023.985404 [doi] LID - 985404 AB - OBJECTIVE: To compare the effects of different aerobic training protocols on cardiometabolic variables in patients with type 2 diabetes mellitus (T2DM). METHODS: This study was a parallel clinical trial. Fifty-two men and women with T2DM (>40 years) were randomly allocated into three groups, and 44 (22 males/22 females) were included in the final analysis. Exercise intensity was based on the speed corresponding to the maximum oxygen consumption (v V O(2)max). Moderate intensity continuous training (MICT) involved 14 minutes at 70% of v V O(2)max; short interval high-intensity interval training (S-HIIT) consisted of 20 bouts of 30 seconds at 100% of V O(2)max with 30 seconds passive recovery; long interval high-intensity training (L-HIIT) consisted of 5 bouts of 2 minutes at 100% of v V O(2)max with 2 minutes passive recovery. Training protocols were performed on a motorized treadmill two times per week for eight weeks. Glycated hemoglobin (Hb1Ac), total cholesterol, triglycerides, resting systolic blood pressure (SBP), resting diastolic blood pressure (DBP), resting heart rate (resting HR) and maximum oxygen consumption (V O(2)max) were measured before and after the exercise intervention. The study was registered on the Brazilian clinical trial records (ID: RBR45 4RJGC3). RESULTS: There was a significant difference between groups for changes on V O(2)max. Greater increases on V O(2)max were achieved for L-HIIT (p = 0.04) and S-HIIT (p = 0.01) in comparison to MICT group, with no significant difference between L-HIIT and S-HIIT (p = 0.9). Regarding comparison within groups, there were significant reductions on HbA1c and triglycerides levels only for L-HIIT (p< 0.05). V O(2)max significantly increased for both L-HIIT (MD = 3.2 +/- 1.7 ml/kg/min, p< 0.001) and S-HIIT (MD = 3.4 +/- 1.7, p< 0.001). There was a significant reduction on resting SBP for L-HIIT group (MD = -12.07 +/- 15.3 mmHg, p< 0.01), but not for S-HIIT and MICT. There were no significant changes from pre- to post-training on fasting glycemia, total cholesterol, HDL, LDL, resting HR and resting DBP for any group (p > 0.05). CONCLUSION: Low-volume HIIT promoted greater improvements in cardiorespiratory capacity in comparison with low-volume MICT, independent of the protocols used. There were no other differences between groups. All protocols improved at least one of the variables analyzed; however, the most evident benefits were after the high-intensity protocols, especially L-HIIT. CI - Copyright (c) 2023 Gentil, Silva, Antunes, Carneiro, de Lira, Batista, Oliveira, Cardoso, Souza and Rebelo. FAU - Gentil, Paulo AU - Gentil P AD - College of Physical Education and Dance, Federal University of Goias, Goiania, Brazil. AD - Hypertension League, Federal University of Goias, Goiania, Brazil. AD - Instituto VIDA, Brasilia, Brazil. FAU - Silva, Lucas Raphael Bento E AU - Silva LRBE AD - College of Physical Education and Dance, Federal University of Goias, Goiania, Brazil. AD - Faculty of Medicine, Federal University of Goias, Goiania, Brazil. AD - Hospital das Clinicas, Federal University of Goias, Goiania, Brazil. FAU - Antunes, Daniela Espindola AU - Antunes DE AD - Hospital das Clinicas, Federal University of Goias, Goiania, Brazil. FAU - Carneiro, Luciana Barbosa AU - Carneiro LB AD - Banco de Olhos Foundation, Goiania, Brazil. FAU - de Lira, Claudio Andre Barbosa AU - de Lira CAB AD - College of Physical Education and Dance, Federal University of Goias, Goiania, Brazil. AD - Faculty of Medicine, Federal University of Goias, Goiania, Brazil. FAU - Batista, Gislene AU - Batista G AD - Faculty of Nutrition, Federal University of Goias, Goiania, Brazil. FAU - de Oliveira, Jordana Campos Martins AU - de Oliveira JCM AD - Faculty of Nutrition, Federal University of Goias, Goiania, Brazil. FAU - Cardoso, John Sebastiao AU - Cardoso JS AD - Faculty of Nutrition, Federal University of Goias, Goiania, Brazil. FAU - Souza, Daniel CostaCosta AU - Souza DC AD - College of Physical Education and Dance, Federal University of Goias, Goiania, Brazil. FAU - Rebelo, Ana Cristina Silva AU - Rebelo ACS AD - College of Physical Education and Dance, Federal University of Goias, Goiania, Brazil. AD - Faculty of Medicine, Federal University of Goias, Goiania, Brazil. AD - Hospital das Clinicas, Federal University of Goias, Goiania, Brazil. LA - eng SI - ReBec/RBR-4RJGC3 PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20230123 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Female MH - Humans MH - Male MH - Blood Pressure/physiology MH - *Cardiovascular Diseases MH - Clinical Protocols MH - *Diabetes Mellitus, Type 2/therapy MH - Exercise Test MH - Respiratory Function Tests MH - *Exercise PMC - PMC9900112 OTO - NOTNLM OT - aerobic exercise (AE) OT - diabetes mellitus OT - exercise is medicine OT - glucose control OT - high-intensity interval training (HIIT) COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/02/10 06:00 MHDA- 2023/02/11 06:00 PMCR- 2023/01/01 CRDT- 2023/02/09 02:19 PHST- 2022/07/03 00:00 [received] PHST- 2023/01/03 00:00 [accepted] PHST- 2023/02/09 02:19 [entrez] PHST- 2023/02/10 06:00 [pubmed] PHST- 2023/02/11 06:00 [medline] PHST- 2023/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2023.985404 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2023 Jan 23;14:985404. doi: 10.3389/fendo.2023.985404. eCollection 2023.