PMID- 36756122
OWN - NLM
STAT- MEDLINE
DCOM- 20240208
LR  - 20240208
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - Dendritic cells in inborn errors of immunity.
PG  - 1080129
LID - 10.3389/fimmu.2023.1080129 [doi]
LID - 1080129
AB  - Dendritic cells (DCs) are crucial cells for initiating and maintaining immune 
      response. They play critical role in homeostasis, inflammation, and autoimmunity. 
      A number of molecules regulate their functions including synapse formation, 
      migration, immunity, and induction of tolerance. A number of IEI are 
      characterized by mutations in genes encoding several of these molecules resulting 
      in immunodeficiency, inflammation, and autoimmunity in IEI. Currently, there are 
      465 Inborn errors of immunity (IEI) that have been grouped in 10 different 
      categories. However, comprehensive studies of DCs have been reported in only few 
      IEI. Here we have reviewed biology of DCs in IEI classified according to recently 
      published IUIS classification. We have reviewed DCs in selected IEI in each group 
      category and discussed in depth changes in DCs where significant data are 
      available regarding role of DCs in clinical and immunological manifestations. 
      These include severe immunodeficiency diseases, antibody deficiencies, combined 
      immunodeficiency with associated and syndromic features, especially disorders of 
      synapse formation, and disorders of immune regulation.
CI  - Copyright (c) 2023 Gupta and Agrawal.
FAU - Gupta, Sudhir
AU  - Gupta S
AD  - Division of Basic and Clinical Immunology, University of California, Irvine, CA, 
      United States.
FAU - Agrawal, Anshu
AU  - Agrawal A
AD  - Division of Basic and Clinical Immunology, University of California, Irvine, CA, 
      United States.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230123
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Humans
MH  - Autoimmunity
MH  - Dendritic Cells
MH  - Inflammation
MH  - *Primary Immunodeficiency Diseases
MH  - Immune Tolerance
PMC - PMC9899832
OTO - NOTNLM
OT  - classical DCs
OT  - dendritic cells
OT  - inborn errors of immunity
OT  - monocyte derived DCs
OT  - myeloid DCs
OT  - plasmacytoid DCs
OT  - primary immunodeficiencies
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/02/10 06:00
MHDA- 2023/02/11 06:00
PMCR- 2023/01/01
CRDT- 2023/02/09 02:22
PHST- 2022/10/25 00:00 [received]
PHST- 2023/01/06 00:00 [accepted]
PHST- 2023/02/09 02:22 [entrez]
PHST- 2023/02/10 06:00 [pubmed]
PHST- 2023/02/11 06:00 [medline]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1080129 [doi]
PST - epublish
SO  - Front Immunol. 2023 Jan 23;14:1080129. doi: 10.3389/fimmu.2023.1080129. 
      eCollection 2023.