PMID- 36756244
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230210
IS  - 2313-1810 (Electronic)
IS  - 2312-0053 (Print)
IS  - 2312-0053 (Linking)
VI  - 38
IP  - 1
DP  - 2023
TI  - Demographic profile of HIV and helminth-coinfected adults in KwaZulu-Natal, South 
      Africa.
PG  - 466
LID - 10.4102/sajid.v38i1.466 [doi]
LID - 466
AB  - BACKGROUND: Helminth and HIV infections are endemic among poor populations. 
      Studies investigating the socio-demographic and economic risk factors associated 
      with dual HIV and helminth coinfection are scarce. OBJECTIVES: This study aimed 
      to describe risk factors associated with HIV and helminth coinfections among 
      peri-urban South African adults residing in poorly developed areas with high 
      poverty levels, lack of sanitation and a clean water supply. METHOD: Adult 
      participants (n = 414) were recruited from clinics in the south of Durban, 
      KwaZulu-Natal, South Africa. Participants' demographic, socio-economic, 
      sanitation and household information, anthropometric measurements and HIV status 
      were collected. Stool samples were donated for coproscopy to detect helminths 
      using the Kato-Katz and Mini Parasep techniques. Blood was collected to confirm 
      participants' HIV status and to determine Ascaris lumbricoides-specific 
      immunoglobulin E (IgE) and immunoglobulin G4 (IgG4) levels to improve microscopy 
      sensitivity. RESULTS: Overall coinfection was 15%, and single helminth and HIV 
      prevalence were 33% and 52%, respectively. Ascaris lumbricoides was predominant 
      (18%). Univariate analysis of variance (ANOVA) showed that coinfection was 11.9% 
      and 19.8%, respectively, among the 18-34 years and 35-59 years age groups (p = 
      0.0006), 16.4% and 19.9%, respectively, for the no income and < R1000.00 groups 
      (p = 0.0358) and 22.8% and 17.1%, respectively, for the pit or public toilets and 
      toilets not connected to sewage groups (p = 0.0007). CONCLUSION: Findings suggest 
      that the dual infection with HIV and helminth infections among adults residing in 
      under-resourced areas with poor sanitary conditions is frequent. Older age, poor 
      toilet use and low income are associated with coinfection. More attention is 
      required to break the cycle of coinfections and possible disease interactions. 
      CONTRIBUTION: The study highlights the importance of determining and treating 
      helminth infections among adult population during HIV and helminth coinfection 
      and the influence of poor sanitation and socioeconomic status on disease 
      transmission.
CI  - (c) 2023. The Authors.
FAU - Mpaka-Mbatha, Miranda N
AU  - Mpaka-Mbatha MN
AUID- ORCID: 0000-0002-4757-1324
AD  - Department of Biomedical Sciences, Faculty of Natural Sciences, Mangosuthu 
      University of Technology, Umlazi, Durban, South Africa.
AD  - Department of Medical Microbiology, College of Health Sciences, School of 
      Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, 
      South Africa.
AD  - Department of Medical Microbiology, College of Health Sciences, School of 
      Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, 
      South Africa.
FAU - Naidoo, Pragalathan
AU  - Naidoo P
AUID- ORCID: 0000-0002-8905-5926
AD  - Department of Medical Microbiology, College of Health Sciences, School of 
      Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, 
      South Africa.
AD  - Division of Research Capacity Development, School of Laboratory Medicine and 
      Medical Sciences, South African Medical Research Council (SAMRC), Cape Town, 
      South Africa.
FAU - Islam, Md Mazharul
AU  - Islam MM
AUID- ORCID: 0000-0002-7357-9645
AD  - Department of Animal Resources, Ministry of Municipality, Doha, Qatar.
FAU - Singh, Ravesh
AU  - Singh R
AUID- ORCID: 0000-0002-0407-4635
AD  - Department of Medical Microbiology, College of Health Sciences, School of 
      Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, 
      South Africa.
FAU - Mkhize-Kwitshana, Zilungile L
AU  - Mkhize-Kwitshana ZL
AUID- ORCID: 0000-0002-0373-9973
AD  - Department of Medical Microbiology, College of Health Sciences, School of 
      Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, 
      South Africa.
AD  - Division of Research Capacity Development, School of Laboratory Medicine and 
      Medical Sciences, South African Medical Research Council (SAMRC), Cape Town, 
      South Africa.
LA  - eng
PT  - Journal Article
DEP - 20230109
PL  - South Africa
TA  - S Afr J Infect Dis
JT  - Southern African journal of infectious diseases
JID - 101646666
PMC - PMC9900356
OTO - NOTNLM
OT  - HIV
OT  - coinfection
OT  - demographic profile
OT  - helminths
OT  - neglected tropical diseases
COIS- The authors declare that they have no financial or personal relationships that 
      may have inappropriately influenced them in writing this article.
EDAT- 2023/02/10 06:00
MHDA- 2023/02/10 06:01
PMCR- 2023/01/09
CRDT- 2023/02/09 02:25
PHST- 2022/07/01 00:00 [received]
PHST- 2022/10/19 00:00 [accepted]
PHST- 2023/02/09 02:25 [entrez]
PHST- 2023/02/10 06:00 [pubmed]
PHST- 2023/02/10 06:01 [medline]
PHST- 2023/01/09 00:00 [pmc-release]
AID - SAJID-38-466 [pii]
AID - 10.4102/sajid.v38i1.466 [doi]
PST - epublish
SO  - S Afr J Infect Dis. 2023 Jan 9;38(1):466. doi: 10.4102/sajid.v38i1.466. 
      eCollection 2023.