PMID- 36756386
OWN - NLM
STAT- MEDLINE
DCOM- 20230213
LR  - 20230213
IS  - 1748-6718 (Electronic)
IS  - 1748-670X (Print)
IS  - 1748-670X (Linking)
VI  - 2023
DP  - 2023
TI  - Thirdhand Smoke May Promote Lung Adenocarcinoma Development through HN1.
PG  - 3407313
LID - 10.1155/2023/3407313 [doi]
LID - 3407313
AB  - Thirdhand smoke (THS) refers to residual tobacco smoking pollutants that can be 
      adsorbed to indoor surfaces and dust and persist for years after active smoking. 
      THS-related chemicals such as N-nitrosonornicotine (NNN) and 
      4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) are tobacco-specific lung 
      carcinogens that involved in lung cancer development and progression. In this 
      study, we computed the differentially expressed genes (DEGs) between THS and 
      paired control samples. THS-related overexpressed genes (OEs) were overlapped 
      with OEs of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). 
      Survival analyses of these overlapped genes were performed using LUAD and LUSC 
      data. 6 genes were selected for validation based on their expression levels and 
      prognostic value. Hematological and neurological expressed 1 (HN1) was further 
      selected due to its novelty in LUAD research. The potential roles of HN1 in LUAD 
      were explored in several ways. In summary, HN1 is overexpressed in THS samples 
      and is associated with the prognosis of patients with LUAD. It may promote cancer 
      progression through several pathways and could serve as a potential therapeutic 
      target especially for THS-related LUAD. In-depth mechanistic studies and clinical 
      trials are warranted.
CI  - Copyright (c) 2023 Jiamin Peng et al.
FAU - Peng, Jiamin
AU  - Peng J
AD  - Department of Clinical Laboratory, Zhejiang Tongde Hospital, Hangzhou, Zhejiang 
      310014, China.
FAU - Shuopeng, Jia
AU  - Shuopeng J
AD  - Department of Clinical Trials Center, National Cancer Center/National Clinical 
      Research Center for Cancer/Hebei Cancer Hospital, Chinese Academy of Medical 
      Sciences, Langfang 065001, China.
FAU - Wang, Huiju
AU  - Wang H
AD  - Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial 
      People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, 
      China.
FAU - Wang, Xin
AU  - Wang X
AUID- ORCID: 0000-0002-4715-4360
AD  - Department of Clinical Trials Center, National Cancer Center/National Clinical 
      Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing 100041, China.
FAU - Wang, Ligang
AU  - Wang L
AUID- ORCID: 0000-0002-0074-446X
AD  - Cancer Center, Department of Ultrasound Medicine, Zhejiang Provincial People's 
      Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, 
      Zhejiang, China.
LA  - eng
PT  - Journal Article
DEP - 20230130
PL  - United States
TA  - Comput Math Methods Med
JT  - Computational and mathematical methods in medicine
JID - 101277751
RN  - 0 (Carcinogens)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 0 (JPT1 protein, human)
SB  - IM
MH  - Humans
MH  - *Adenocarcinoma of Lung/genetics
MH  - Carcinogens
MH  - *Carcinoma, Squamous Cell/genetics
MH  - *Lung Neoplasms/genetics
MH  - *Tobacco Smoke Pollution/adverse effects/analysis
PMC - PMC9902119
COIS- The authors declare no competing financial interests.
EDAT- 2023/02/10 06:00
MHDA- 2023/02/11 06:00
PMCR- 2023/01/30
CRDT- 2023/02/09 02:27
PHST- 2022/10/18 00:00 [received]
PHST- 2022/10/31 00:00 [revised]
PHST- 2022/11/24 00:00 [accepted]
PHST- 2023/02/09 02:27 [entrez]
PHST- 2023/02/10 06:00 [pubmed]
PHST- 2023/02/11 06:00 [medline]
PHST- 2023/01/30 00:00 [pmc-release]
AID - 10.1155/2023/3407313 [doi]
PST - epublish
SO  - Comput Math Methods Med. 2023 Jan 30;2023:3407313. doi: 10.1155/2023/3407313. 
      eCollection 2023.