PMID- 36758650
OWN - NLM
STAT- MEDLINE
DCOM- 20230322
LR  - 20230327
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 174
DP  - 2023 Apr
TI  - The mechanisms and functions of TNF-alpha in intervertebral disc degeneration.
PG  - 112119
LID - S0531-5565(23)00040-2 [pii]
LID - 10.1016/j.exger.2023.112119 [doi]
AB  - Low back pain (LBP) is one of the most common health problems in people's lives, 
      which brings a massive burden to clinicians, and the leading cause of LBP is 
      intervertebral disc degeneration (IDD). IDD is mainly caused by factors such as 
      aging, mechanical stress, and lack of nutrition. The pathological mechanism of 
      IDD is very complex, involving inflammatory response, cell metabolism disorder, 
      and so on. Unfortunately, in the current treatment of IDD, only relieving 
      symptoms as the primary means of relieving a patient's pain cannot effectively 
      inhibit or reverse the progression of IDD. Tumor necrosis factor-alpha (TNF-alpha) is a 
      multifunctional pro-inflammatory factor involved in many diseases' pathological 
      processes. With the in-depth study of the pathological mechanism of IDD, more and 
      more evidence has shown that TNF-alpha is an essential activator of IDD, which is 
      related to the metabolic disorder, inflammatory responses, apoptosis, and other 
      pathological processes of extracellular dissociation in the intervertebral disc. 
      Therefore, anti-TNF-alpha therapy is an effective therapeutic target for alleviating 
      IDD, especially in inhibiting extracellular matrix degradation and reducing 
      inflammatory responses. This article reviews the pathological role of TNF-alpha in 
      IDD and the latest research progress of TNF-alpha inhibitors in treating IDD.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Pan, Hongyu
AU  - Pan H
AD  - Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, Sichuan, China.
FAU - Li, Hongtao
AU  - Li H
AD  - Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, Sichuan, China.
FAU - Guo, Sheng
AU  - Guo S
AD  - Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, Sichuan, China.
FAU - Wang, Chenglong
AU  - Wang C
AD  - Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, Sichuan, China.
FAU - Long, Longhai
AU  - Long L
AD  - Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, Sichuan, China.
FAU - Wang, Xiaoqiang
AU  - Wang X
AD  - Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, Sichuan, China.
FAU - Shi, Houyin
AU  - Shi H
AD  - Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, Sichuan, China.
FAU - Zhang, Kaiquan
AU  - Zhang K
AD  - Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, Sichuan, China.
FAU - Chen, Hui
AU  - Chen H
AD  - Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, Sichuan, China. Electronic 
      address: huige10141118@163.com.
FAU - Li, Sen
AU  - Li S
AD  - Department of Spinal Surgery, The Affiliated Traditional Chinese Medicine 
      Hospital of Southwest Medical University, Luzhou, Sichuan, China. Electronic 
      address: jht187@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230209
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Tumor Necrosis Factor Inhibitors)
SB  - IM
MH  - Humans
MH  - *Intervertebral Disc Degeneration/drug therapy/metabolism/pathology
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Tumor Necrosis Factor Inhibitors/metabolism/pharmacology
MH  - *Intervertebral Disc/metabolism/pathology
OTO - NOTNLM
OT  - Inflammatory response
OT  - Intervertebral disc degeneration
OT  - Pro-inflammatory factor
OT  - TNF-alpha
COIS- Declaration of competing interest All authors report no conflicts of interest.
EDAT- 2023/02/10 06:00
MHDA- 2023/03/23 06:00
CRDT- 2023/02/09 19:23
PHST- 2022/12/13 00:00 [received]
PHST- 2023/02/06 00:00 [revised]
PHST- 2023/02/06 00:00 [accepted]
PHST- 2023/02/10 06:00 [pubmed]
PHST- 2023/03/23 06:00 [medline]
PHST- 2023/02/09 19:23 [entrez]
AID - S0531-5565(23)00040-2 [pii]
AID - 10.1016/j.exger.2023.112119 [doi]
PST - ppublish
SO  - Exp Gerontol. 2023 Apr;174:112119. doi: 10.1016/j.exger.2023.112119. Epub 2023 
      Feb 9.