PMID- 36758743
OWN - NLM
STAT- MEDLINE
DCOM- 20230529
LR  - 20230531
IS  - 1535-7732 (Electronic)
IS  - 1051-0443 (Linking)
VI  - 34
IP  - 6
DP  - 2023 Jun
TI  - Preliminary Study of Microwave Ablation for Multifocal Papillary Thyroid 
      Microcarcinoma in Nonoperative Candidates.
PG  - 999-1006
LID - S1051-0443(23)00124-0 [pii]
LID - 10.1016/j.jvir.2023.01.035 [doi]
AB  - PURPOSE: To study the feasibility, safety, and effectiveness of microwave 
      ablation (MWA) in patients with multifocal papillary thyroid microcarcinoma 
      (PTMC). MATERIALS AND METHODS: This retrospective study included patients who 
      underwent MWA for multifocal PTMC (number of nodules </=3). A total of 44 patients 
      were included, and the mean age was 43 years (SD +/- 11). After ablation, 
      progression-free survival (PFS) at 6, 12, 24, 36, and 48 months; disease 
      progression; change in tumor size and volume; tumor disappearance rate; and 
      adverse events (AEs) were assessed, and the feasibility, safety, and 
      effectiveness of MWA for PTMC were evaluated on the basis of statistical 
      analysis. RESULTS: The median follow-up period was 18 months (interquartile 
      range, 12-33 months). The PFS rates at 6, 12, 24, 36, and 48 months were 100.0%, 
      96.4%, 96.4%, 70.3%, and 52.7%, respectively. The disease progression rate was 
      11.4% (5 of 44 patients). The maximum diameter (MD) and volume of the ablation 
      zone were larger at the 3-month follow-up than before ablation (median MD, 13.0 
      vs 7.0 mm; P < .001; median volume, 503.8 vs 113.0 mm(3); P < .001). 
      Subsequently, the tumors exhibited a reduction in both size and volume after 18 
      months (median MD, 4.0 vs 7.0 mm; P = .04; median volume, 12.6 vs 113.0 mm(3); 
      P = .055). At the end of the follow-up period, the complete response rate was 59% 
      (26 of 44 patients). The overall AE rate was 6.8%. CONCLUSIONS: MWA is a feasible 
      treatment for PTMC (number of nodules </=3), and this study preliminarily 
      demonstrated the safety and effectiveness of this technique.
CI  - Copyright (c) 2023 SIR. Published by Elsevier Inc. All rights reserved.
FAU - Yu, Xin-Yu
AU  - Yu XY
AD  - Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, People's 
      Republic of China.
FAU - Zhou, Hui-Di
AU  - Zhou HD
AD  - Department of Interventional Medicine, China-Japan Friendship Hospital, Beijing, 
      People's Republic of China.
FAU - Wei, Ying
AU  - Wei Y
AD  - Department of Interventional Medicine, China-Japan Friendship Hospital, Beijing, 
      People's Republic of China.
FAU - Zhao, Zhen-Long
AU  - Zhao ZL
AD  - Department of Interventional Medicine, China-Japan Friendship Hospital, Beijing, 
      People's Republic of China.
FAU - Peng, Li-Li
AU  - Peng LL
AD  - Department of Interventional Medicine, China-Japan Friendship Hospital, Beijing, 
      People's Republic of China.
FAU - Li, Yan
AU  - Li Y
AD  - Department of Interventional Medicine, China-Japan Friendship Hospital, Beijing, 
      People's Republic of China.
FAU - Lu, Nai-Cong
AU  - Lu NC
AD  - Department of Interventional Medicine, China-Japan Friendship Hospital, Beijing, 
      People's Republic of China.
FAU - Yu, Ming-An
AU  - Yu MA
AD  - Department of Interventional Medicine, China-Japan Friendship Hospital, Beijing, 
      People's Republic of China. Electronic address: yma301@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230208
PL  - United States
TA  - J Vasc Interv Radiol
JT  - Journal of vascular and interventional radiology : JVIR
JID - 9203369
RN  - Papillary Thyroid Microcarcinoma
SB  - IM
MH  - Humans
MH  - Adult
MH  - Retrospective Studies
MH  - *Microwaves/adverse effects
MH  - *Thyroid Neoplasms/diagnostic imaging/surgery
MH  - Disease Progression
MH  - Treatment Outcome
EDAT- 2023/02/10 06:00
MHDA- 2023/05/29 06:42
CRDT- 2023/02/09 19:24
PHST- 2022/06/04 00:00 [received]
PHST- 2023/01/20 00:00 [revised]
PHST- 2023/01/29 00:00 [accepted]
PHST- 2023/05/29 06:42 [medline]
PHST- 2023/02/10 06:00 [pubmed]
PHST- 2023/02/09 19:24 [entrez]
AID - S1051-0443(23)00124-0 [pii]
AID - 10.1016/j.jvir.2023.01.035 [doi]
PST - ppublish
SO  - J Vasc Interv Radiol. 2023 Jun;34(6):999-1006. doi: 10.1016/j.jvir.2023.01.035. 
      Epub 2023 Feb 8.