PMID- 36759301
OWN - NLM
STAT- MEDLINE
DCOM- 20230411
LR  - 20230411
IS  - 0035-3787 (Print)
IS  - 0035-3787 (Linking)
VI  - 179
IP  - 4
DP  - 2023 Apr
TI  - From neurons to the neuro-glio-vascular unit: Seizures and brain homeostasis in 
      networks.
PG  - 308-315
LID - S0035-3787(23)00748-8 [pii]
LID - 10.1016/j.neurol.2022.12.005 [doi]
AB  - While seizures are undoubtedly neuronal events, an ensemble of auxiliary brain 
      cells profoundly shapes synaptic transmission in health and disease conditions. 
      Endothelial-astrocyte-pericyte assemblies at the blood-brain barrier (BBB) and 
      neuroglia within the neuro-glio-vascular unit (NGVU) finely tune brain 
      parenchymal homeostasis, safeguarding the ionic and molecular compositions of the 
      interstitial fluid. BBB permeability with neuroinflammation and the resulting 
      loss of brain homeostatic control are unifying mechanisms sustaining aberrant 
      neuronal discharges, with temporal specificities linked to acute (head trauma, 
      stroke, infections) and pre-existent (genetic) or chronic ( dysplasia, tumors, 
      neurodegenerative disorders) pathological conditions. Within this research 
      template, one hypothesis is that the topography of BBB damage and 
      neuroinflammation could associate with symptoms, e.g., limbic structures for 
      seizures or pre-frontal for psychiatric episodes. Another uncharted matter is 
      whether seizure activity, without tissue lesions or sclerosis, is sufficient to 
      promote stable cellular-level maladaptations in networks. Contingent to 
      localization and duration, BBB damage and inflammation forecast pathological 
      trajectories, and the concept of an epileptic NGVU could enable time-sensitive 
      biomarkers to predict disease progression. The coherence between electrographic, 
      imaging and molecular NGVU biomarkers could be established from the epileptogenic 
      to the propagating zones. This paradigm shift could lead to new diagnostic and 
      therapeutic modalities germane to specific epilepsies or when seizure activity 
      represents a comorbidity.
CI  - Copyright (c) 2023 Elsevier Masson SAS. All rights reserved.
FAU - Cresto, N
AU  - Cresto N
AD  - Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, 
      Montpellier, France.
FAU - Janvier, A
AU  - Janvier A
AD  - Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, 
      Montpellier, France.
FAU - Marchi, N
AU  - Marchi N
AD  - Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, 
      Montpellier, France. Electronic address: nicola.marchi@igf.cnrs.fr.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230208
PL  - France
TA  - Rev Neurol (Paris)
JT  - Revue neurologique
JID - 2984779R
SB  - IM
MH  - Humans
MH  - *Neuroinflammatory Diseases
MH  - Brain/pathology
MH  - Seizures/diagnosis/etiology
MH  - Blood-Brain Barrier/pathology
MH  - Neurons/pathology
MH  - *Epilepsy/diagnosis/etiology/pathology
MH  - Homeostasis
OTO - NOTNLM
OT  - Astrocytes
OT  - Biomarkers
OT  - Blood-brain barrier
OT  - Epileptogenic
OT  - Homeostasis
OT  - Immunity
OT  - Inflammation
OT  - Microglia
OT  - Pericytes
OT  - Seizure propagation
EDAT- 2023/02/10 06:00
MHDA- 2023/04/11 06:41
CRDT- 2023/02/09 22:03
PHST- 2022/11/08 00:00 [received]
PHST- 2022/12/05 00:00 [revised]
PHST- 2022/12/06 00:00 [accepted]
PHST- 2023/04/11 06:41 [medline]
PHST- 2023/02/10 06:00 [pubmed]
PHST- 2023/02/09 22:03 [entrez]
AID - S0035-3787(23)00748-8 [pii]
AID - 10.1016/j.neurol.2022.12.005 [doi]
PST - ppublish
SO  - Rev Neurol (Paris). 2023 Apr;179(4):308-315. doi: 10.1016/j.neurol.2022.12.005. 
      Epub 2023 Feb 8.