PMID- 36760583
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230211
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - Reduced Serum Levels of Klotho are Associated with Mild Cognitive Impairment in 
      Patients with Type 2 Diabetes Mellitus.
PG  - 129-137
LID - 10.2147/DMSO.S394099 [doi]
AB  - OBJECTIVE: The study objective was to investigate the serum levels of Klotho in 
      patients with type 2 diabetes mellitus (T2DM) who had moderate cognitive 
      impairment (MCI) and those without MCI and to determine its prediction of MCI in 
      older patients with T2DM. METHODS: Patients with diabetes were examined for MCI 
      in 292 cases (using the Montreal Cognitive Assessment: MoCA score). Biomarkers 
      and biochemical parameter data were accumulated. RESULTS: Comparing T2DM patients 
      with MCI (91 patients) and without MCI (101 patients), patients with MCI 
      considerably reduced serum Klotho levels were observed. In all 292 hospitalized 
      patients, serum Klotho levels were negatively correlated with age (r=-0.184, 
      P=0.002), body mass index (BMI) (r=-0.151, P=0.010), glycosylated hemoglobin 
      (HbA1c) (r=-0.197, P=0.001), creatinine (r=-0.178, P=0.002), and C-reactive 
      protein (CRP) (r=-0.319, P<0.001). On the other hand, it is positively correlated 
      with education (r=0.319, P<0.001) and high-density lipoprotein cholesterol 
      (HDL-C) (r=0.272, P<0.001). Considering the findings of the multivariate logistic 
      regression models, patients with type 2 diabetes who had reduced levels of serum 
      Klotho (OR=0.987, 95% CI=0.980-0.994; P<0.001), lower HDL-C, increased levels of 
      HbA1c, creatinine, and CRP, and limited years of formal education and a longer 
      duration of T2DM, increase the risk of developing MCI. CONCLUSION: The results 
      showed that diabetic patients with MCI have lower serum Klotho levels than 
      diabetic patients without MCI. It might be possible to do a more extensive 
      population-based prospective investigation to confirm the correlation between 
      serum Klotho levels and cognitive impairment or dementia.
CI  - (c) 2023 Zhang et al.
FAU - Zhang, Haina
AU  - Zhang H
AD  - Department of General Medicine, Shanghai Pudong Hospital, Fudan University Pudong 
      Medical Center, Pudong, Shanghai, 201399, People's Republic of China.
FAU - Yu, Lou
AU  - Yu L
AD  - Department of Preventive Treatment, Shanghai Seventh People's Hospital, Shanghai, 
      200137, People's Republic of China.
FAU - Yun, Gai
AU  - Yun G
AD  - Department of General Medicine, Seventh People's Hospital of Shanghai University 
      of TCM, Shanghai, 200137, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230115
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC9851628
OTO - NOTNLM
OT  - Klotho
OT  - MCI
OT  - T2DM
OT  - cognitive impairment
OT  - type 2 diabetes mellitus
COIS- The authors declare that they have no competing of interests.
EDAT- 2023/02/11 06:00
MHDA- 2023/02/11 06:01
PMCR- 2023/01/15
CRDT- 2023/02/10 02:58
PHST- 2022/11/14 00:00 [received]
PHST- 2022/12/16 00:00 [accepted]
PHST- 2023/02/10 02:58 [entrez]
PHST- 2023/02/11 06:00 [pubmed]
PHST- 2023/02/11 06:01 [medline]
PHST- 2023/01/15 00:00 [pmc-release]
AID - 394099 [pii]
AID - 10.2147/DMSO.S394099 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 Jan 15;16:129-137. doi: 10.2147/DMSO.S394099. 
      eCollection 2023.