PMID- 36760808 OWN - NLM STAT- MEDLINE DCOM- 20230213 LR - 20230227 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 13 DP - 2022 TI - Altered dynamic functional architecture in type 2 diabetes mellitus. PG - 1117735 LID - 10.3389/fendo.2022.1117735 [doi] LID - 1117735 AB - INTRODUCTION: Type 2 diabetes mellitus (T2DM) can accelerate cognitive decline and even dementia so that the underlying mechanism deserves further exploration. In the resting state, brain function is still changing dynamically. At present, it is still unknown whether the dynamic functional connectivity (dFC) between various brain regions is in a stable state. It is necessary to interpret brain changes from a new perspective, that is, the stability of brain architecture. METHODS: In this study, we used a fixed dynamic time scale to explore the stability of dynamic functional architecture in T2DM, then the dynamic effective connectivity (dEC) was used to further explain how information flows through dynamically fluctuating brain architecture in T2DM. RESULT: Two brain regions with decreased stability were found including the right supra-marginal gyrus (SMG) and the right median cingulate gyrus (MCG) in T2DM subjects. The dEC variation has increased between the left inferior frontal gyrus (IFG) and the right MCG. The direction of causal flow is from the right MCG to the left IFG. CONCLUSION: The combination of stability and dEC can not only show the stability of dynamic functional architecture in brain but also reflect the fluidity of brain information, which is an innovative and interesting attempt in the field of neuroimaging. The changes of dynamic architecture in T2DM patients may present an innovative perspective and explanation for their cognitive decline. CI - Copyright (c) 2023 Li, Li, Zhao, Wang, Tan, Qin, Rao, Sun, Ge, Cao, Liang and Qiu. FAU - Li, Yifan AU - Li Y AD - First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Li, Mingrui AU - Li M AD - First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Magnetic Resonance Imaging, Zhanjiang First Hospital of Traditional Chinese Medicine, Zhanjiang, China. FAU - Zhao, Kui AU - Zhao K AD - First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Wang, Yan AU - Wang Y AD - First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Tan, Xin AU - Tan X AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Qin, Chunhong AU - Qin C AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Rao, Yawen AU - Rao Y AD - First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Sun, Zhizhong AU - Sun Z AD - First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Ge, Limin AU - Ge L AD - First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Cao, Zidong AU - Cao Z AD - First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Liang, Yi AU - Liang Y AD - First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Qiu, Shijun AU - Qiu S AD - First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Department of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20230124 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2 MH - Magnetic Resonance Imaging/methods MH - Brain/diagnostic imaging MH - *Cognitive Dysfunction/diagnostic imaging/etiology MH - Neuroimaging PMC - PMC9903314 OTO - NOTNLM OT - cognitive decline OT - dynamic effective connectivity OT - dynamic functional stability OT - functional architecture OT - resting state OT - type 2 diabetes mellitus COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2023/02/11 06:00 MHDA- 2023/02/14 06:00 PMCR- 2022/01/01 CRDT- 2023/02/10 03:01 PHST- 2022/12/06 00:00 [received] PHST- 2022/12/29 00:00 [accepted] PHST- 2023/02/10 03:01 [entrez] PHST- 2023/02/11 06:00 [pubmed] PHST- 2023/02/14 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2022.1117735 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2023 Jan 24;13:1117735. doi: 10.3389/fendo.2022.1117735. eCollection 2022.