PMID- 36762055 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230710 IS - 2218-6751 (Print) IS - 2226-4477 (Electronic) IS - 2218-6751 (Linking) VI - 12 IP - 1 DP - 2023 Jan 31 TI - Efficacy and safety of gemcitabine and capecitabine combination for patients with previously treated advanced primary pulmonary lymphoepithelioma-like carcinoma: a retrospective single-arm cohort study. PG - 96-108 LID - 10.21037/tlcr-22-256 [doi] AB - BACKGROUND: Primary pulmonary lymphoepithelioma-like carcinoma (PLELC) is a rare and unique subtype of non-small cell lung cancer (NSCLC). Studies reporting on salvage treatment for pretreated PLELC are limited. Positive interactions between gemcitabine (GEM) and capecitabine (CAP) have been demonstrated in preclinical studies. In addition, the clinical benefit of the combination has been reported for other malignancies. However, the efficacy and safety of the combination for pretreated PLELC remain unclear. Therefore, we conducted this retrospective study to examine the activity and safety of gemcitabine plus capecitabine (GEM/CAP) combination for previously treated PLELC. METHODS: Patients with PLELC at Sun Yat-sen University Cancer Center who received GEM combined with CAP between May 2013 and January 2021 as the second-line therapy or beyond were retrospectively enrolled. Treatment consisted of intravenous GEM (1,000 mg/m(2) on days 1 and 8) and oral CAP (1,000 mg/m(2) twice daily on days 1-14) every 3 weeks. Evaluation of response was performed every 2 cycles in accordance with Response Evaluation Criteria in Solid Tumors version 1.1. Safety was assessed in accordance with Common Terminology Criteria for Adverse Events version 5.0. Clinical characteristics were collected from medical records. The survival data were obtained by medical records or telephone. Follow-ups were performed until February 3(rd), 2021. RESULTS: A total of 16 patients were enrolled in this study. There were 5, 4, 4, and 3 patients treated with GEM/CAP combination as the second-, third-, fourth-, and fifth-line settings, respectively. There were 8 patients with partial response (PR) (50.00%), 6 with stable disease (SD) (37.50%), 2 with progressive disease (PD) (12.50%), and none with complete response (CR). The objective response rate and disease control rate (DCR) were 50.00% and 87.50%, respectively. The most common hematological and nonhematological adverse events (AEs) at any grade were neutropenia (31.25%) and hand-foot syndrome (43.75%). At a median follow-up of 29.3 months with 95% confidence interval (CI) of 20.3 to 38.3 months, the median progression-free survival (PFS) was 9.3 months (95% CI: 6.5-12.1 months). The median overall survival (OS) was 41.5 months (95% CI: 3.1-79.8 months). CONCLUSIONS: This retrospective study demonstrated the potential clinical benefit of GEM in combination with CAP for pretreated PLELC. Future multicenter large-scale, prospective studies are warranted. CI - 2023 Translational Lung Cancer Research. All rights reserved. FAU - Zou, Qi-Hua AU - Zou QH AD - Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. AD - State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. FAU - Liu, Hui AU - Liu H AD - State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. AD - Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. FAU - Huang, Cai-Wen AU - Huang CW AD - Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. AD - State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. AD - Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China. FAU - Kang, Li-Ping AU - Kang LP AD - Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. AD - State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. FAU - Qiu, Bo AU - Qiu B AD - State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. AD - Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. FAU - Mai, Jian-Liang AU - Mai JL AD - Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. AD - State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. FAU - Lin, Yong-Bin AU - Lin YB AD - State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. AD - Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China. FAU - Liang, Ying AU - Liang Y AD - Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. AD - State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China. LA - eng PT - Journal Article DEP - 20230116 PL - China TA - Transl Lung Cancer Res JT - Translational lung cancer research JID - 101646875 CIN - Transl Lung Cancer Res. 2023 Jun 30;12(6):1143-1146. PMID: 37425409 PMC - PMC9903090 OTO - NOTNLM OT - Primary pulmonary lymphoepithelioma-like carcinoma (PLELC) OT - capecitabine OT - gemcitabine OT - salvage chemotherapy COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-22-256/coif). All authors report that the study was supported by the Medical Scientific Research Foundation of Guangdong Province of China (No. A2017186). The authors have no other conflicts of interest to declare. EDAT- 2023/02/11 06:00 MHDA- 2023/02/11 06:01 PMCR- 2023/01/31 CRDT- 2023/02/10 03:19 PHST- 2022/04/03 00:00 [received] PHST- 2022/12/02 00:00 [accepted] PHST- 2023/02/10 03:19 [entrez] PHST- 2023/02/11 06:00 [pubmed] PHST- 2023/02/11 06:01 [medline] PHST- 2023/01/31 00:00 [pmc-release] AID - tlcr-12-01-96 [pii] AID - 10.21037/tlcr-22-256 [doi] PST - ppublish SO - Transl Lung Cancer Res. 2023 Jan 31;12(1):96-108. doi: 10.21037/tlcr-22-256. Epub 2023 Jan 16.