PMID- 36763139 OWN - NLM STAT- MEDLINE DCOM- 20230628 LR - 20230628 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) VI - 44 IP - 6 DP - 2023 Aug TI - Ventricular Arrhythmic Events After Transcatheter Pulmonary Valve Replacement in Adults with Repaired Tetralogy of Fallot. PG - 1226-1231 LID - 10.1007/s00246-023-03120-1 [doi] AB - Arrhythmias are a major cause of morbidity and mortality in repaired Tetralogy of Fallot (rTOF). However, predicting those at risk for life-threatening ventricular arrhythmias (VA) remains difficult. Many centers approach risk assessment at the time of surgical pulmonary valve intervention. Increasing numbers of patients have undergone transcatheter pulmonary valve replacement (TPVR), yet there are no studies evaluating VA in rTOF undergoing TPVR and the approach to risk assessment for these patients. A single center retrospective study was performed. The institutional interventional database was queried to identify all adults >/= 18 years of age with rTOF status who underwent TPVR from 2010 to 2019. A total of 81 patients with rTOF underwent TPVR from 2010 to 2019. Mean age at time of TPVR was 27 +/- 13 years; follow up after TPVR was 6.4 +/- 3.1 years. VA events occurred in 4 patients (5%). There was no significant difference in current era VA risk factors in rTOF patients between the VA event group and the non-VA event group. VA risk in this cohort of rTOF with TPVR was 5%, comparable to that reported in current era surgical cohort with similar follow up. Multi-center agreement on risk assessment protocol is needed for future studies. CI - (c) 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Dodeja, Anudeep K AU - Dodeja AK AD - Division of Cardiology, Connecticut Children's, Hartford, CT, USA. FAU - Daniels, Zachary AU - Daniels Z AD - Department of Pediatrics, Division of Cardiovascular Medicine, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Mah, May Ling AU - Mah ML AD - Department of Pediatrics, Division of Cardiovascular Medicine, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Shay, Victoria AU - Shay V AD - Department of Pediatrics, Division of Cardiovascular Medicine, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Bai, Shasha AU - Bai S AD - Pediatric Biostatistics Core, Department of Pediatrics, Emory University, Atlanta, GA, USA. FAU - Hor, Kan AU - Hor K AD - Department of Pediatrics, Division of Cardiovascular Medicine, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Kertesz, Naomi AU - Kertesz N AD - Department of Pediatrics, Division of Cardiovascular Medicine, Nationwide Children's Hospital, Columbus, OH, USA. AD - Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. FAU - Daniels, Curt AU - Daniels C AD - Department of Pediatrics, Division of Cardiovascular Medicine, Nationwide Children's Hospital, Columbus, OH, USA. AD - Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. FAU - Kamp, Anna AU - Kamp A AD - Department of Pediatrics, Division of Cardiovascular Medicine, Nationwide Children's Hospital, Columbus, OH, USA. anna.kamp@nationwidechildrens.org. AD - Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA. anna.kamp@nationwidechildrens.org. AD - T3-3234, The Heart Center, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA. anna.kamp@nationwidechildrens.org. LA - eng PT - Journal Article DEP - 20230210 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM MH - Adult MH - Humans MH - Adolescent MH - Young Adult MH - *Pulmonary Valve/surgery MH - *Tetralogy of Fallot MH - *Heart Valve Prosthesis Implantation/methods MH - Retrospective Studies MH - Cardiac Catheterization/methods MH - Treatment Outcome MH - *Pulmonary Valve Insufficiency/etiology/surgery OTO - NOTNLM OT - Adult congenital heart disease OT - Tetralogy of Fallot OT - Transcatheter pulmonary valve replacement OT - Ventricular arrhythmia EDAT- 2023/02/11 06:00 MHDA- 2023/06/28 06:42 CRDT- 2023/02/10 11:14 PHST- 2022/11/22 00:00 [received] PHST- 2023/01/30 00:00 [accepted] PHST- 2023/06/28 06:42 [medline] PHST- 2023/02/11 06:00 [pubmed] PHST- 2023/02/10 11:14 [entrez] AID - 10.1007/s00246-023-03120-1 [pii] AID - 10.1007/s00246-023-03120-1 [doi] PST - ppublish SO - Pediatr Cardiol. 2023 Aug;44(6):1226-1231. doi: 10.1007/s00246-023-03120-1. Epub 2023 Feb 10.