PMID- 36763246
OWN - NLM
STAT- MEDLINE
DCOM- 20230717
LR  - 20230718
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Print)
IS  - 0391-4097 (Linking)
VI  - 46
IP  - 8
DP  - 2023 Aug
TI  - Are glucose and insulin levels at all time points during OGTT a reliable marker 
      of diabetes mellitus risk in pediatric obesity?
PG  - 1685-1694
LID - 10.1007/s40618-023-02030-6 [doi]
AB  - PURPOSE: Childhood overweight and obesity associated with insulin resistance and 
      metabolic syndrome represent the new global pandemic and the main causative 
      factors for dysglycemia, prediabetes, and Type 2 Diabetes Mellitus (T2DM). 
      Predictors, such as HOMA-IR, HOMA-beta%, and QUICKI lack specific reference values 
      in children. OGTT is a gold standard for glycometabolic assessment. Recently, a 
      glycemic level higher than 155 mg/dl at + 60' after glucose ingestion has been 
      defined as a risk factor for T2DM in obese adolescents. We aim to analyze and 
      correlate fasting insulin-resistance markers with OGTT results in 
      overweight/obese children and adolescents. METHODS: We retrospectively evaluated 
      glucose and insulin values during a 2-h OGTT every 30 min in 236 overweight/obese 
      patients. Glucose values and insulin sum during OGTT were compared to 
      glycometabolic indexes and different cut-off values for insulin sum. RESULTS: A 
      1-h glucose > 155 mg/dl and insulin sum > 535 microU/ml at all times during OGTT 
      are the best predictors of diabetes risk in obese youths. A1-h 
      glucose > 155 mg/dl is significantly associated with HbA1c > 5.7%, while no 
      association was observed between HbA1c > 5.7% and glucose levels at baseline and 
      2 h. The ability of the standardized HOMA-IR to predict the prediabetes status is 
      clearly lower than the total insulin sum at OGTT. CONCLUSION: Our study 
      demonstrates that also 1-h post-OGTT glucose, together with HbA1c, is an 
      effective diabetes predictor.
CI  - (c) 2023. The Author(s).
FAU - La Valle, A
AU  - La Valle A
AD  - Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 
      Italy.
FAU - d'Annunzio, G
AU  - d'Annunzio G
AUID- ORCID: 0000-0002-1856-2277
AD  - Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 
      Italy.
FAU - Campanello, C
AU  - Campanello C
AD  - Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 
      Italy.
FAU - Tantari, G
AU  - Tantari G
AD  - Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 
      Italy.
FAU - Pistorio, A
AU  - Pistorio A
AUID- ORCID: 0000-0002-6895-8720
AD  - Epidemiology and Biostatistics Department, IRCCS Istituto Giannina Gaslini, 
      Genoa, Italy.
FAU - Napoli, F
AU  - Napoli F
AUID- ORCID: 0000-0003-3567-6118
AD  - Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 
      Italy.
FAU - Patti, G
AU  - Patti G
AUID- ORCID: 0000-0002-6217-1919
AD  - Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 
      Italy.
AD  - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and 
      Child Health, University of Genoa, Genoa, Italy.
FAU - Crocco, M
AU  - Crocco M
AUID- ORCID: 0000-0001-7277-4767
AD  - Gastroenterology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
FAU - Bassi, M
AU  - Bassi M
AUID- ORCID: 0000-0002-9166-1079
AD  - Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 
      Italy.
AD  - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and 
      Child Health, University of Genoa, Genoa, Italy.
FAU - Minuto, N
AU  - Minuto N
AUID- ORCID: 0000-0002-5280-6319
AD  - Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 
      Italy.
FAU - Piccolo, G
AU  - Piccolo G
AUID- ORCID: 0000-0003-2815-6288
AD  - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and 
      Child Health, University of Genoa, Genoa, Italy. gianlucapiccolo@gaslini.org.
AD  - Neurooncology Unit, IRCCS Istituto Giannina Gaslini, Via G. Gaslini 5, 16147, 
      Genoa, Italy. gianlucapiccolo@gaslini.org.
FAU - Maghnie, M
AU  - Maghnie M
AUID- ORCID: 0000-0002-7183-5238
AD  - Pediatric Clinic and Endocrinology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 
      Italy.
AD  - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and 
      Child Health, University of Genoa, Genoa, Italy.
LA  - eng
PT  - Journal Article
DEP - 20230210
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - IY9XDZ35W2 (Glucose)
RN  - 0 (Glycated Hemoglobin)
RN  - 0 (Insulin)
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adolescent
MH  - Humans
MH  - Child
MH  - Glucose/metabolism
MH  - *Pediatric Obesity/complications/diagnosis
MH  - Glucose Tolerance Test
MH  - *Prediabetic State/diagnosis
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - Glycated Hemoglobin
MH  - Overweight
MH  - Retrospective Studies
MH  - *Insulin Resistance
MH  - Insulin
MH  - Blood Glucose/metabolism
PMC - PMC10349010
OTO - NOTNLM
OT  - HOMA-IR
OT  - Insulin resistance
OT  - OGTT
OT  - Pediatric obesity
OT  - Type 2 diabetes mellitus
COIS- The authors have no relevant financial or non-financial interests to disclose.
EDAT- 2023/02/11 06:00
MHDA- 2023/07/17 06:42
PMCR- 2023/02/10
CRDT- 2023/02/10 11:20
PHST- 2022/10/01 00:00 [received]
PHST- 2023/02/01 00:00 [accepted]
PHST- 2023/07/17 06:42 [medline]
PHST- 2023/02/11 06:00 [pubmed]
PHST- 2023/02/10 11:20 [entrez]
PHST- 2023/02/10 00:00 [pmc-release]
AID - 10.1007/s40618-023-02030-6 [pii]
AID - 2030 [pii]
AID - 10.1007/s40618-023-02030-6 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2023 Aug;46(8):1685-1694. doi: 10.1007/s40618-023-02030-6. 
      Epub 2023 Feb 10.