PMID- 36764558
OWN - NLM
STAT- MEDLINE
DCOM- 20230313
LR  - 20240502
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 871
DP  - 2023 May 1
TI  - Blood trihalomethane concentrations and allergic sensitization: A nationwide 
      cross-sectional study.
PG  - 162100
LID - S0048-9697(23)00716-7 [pii]
LID - 10.1016/j.scitotenv.2023.162100 [doi]
AB  - BACKGROUND: Exposure to disinfection by-products has been associated with several 
      allergic diseases, but its association with allergen-specific immunoglobulin E 
      (IgE) antibodies remains inconclusive. METHODS: We included 932 U.S. adolescents 
      and 2187 adults from the National Health and Nutrition Examination Survey 
      2005-2006 who had quantified blood THM concentrations [chloroform (TCM), 
      bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM)] 
      and 19 allergen-specific IgE antibodies. The odds ratios (ORs) of 
      allergen-specific sensitization per 2.7-fold increment in blood THM 
      concentrations were estimated by multivariable logistic regression models. 
      RESULTS: Blood THM concentrations were unrelated to any allergen-specific 
      sensitization in adults. Among adolescents, however, we found positive 
      associations between blood TCM and chlorinated THMs (Cl-THMs: sum of TCM, BDCM, 
      and DBCM) concentrations and the odds of pet sensitization [OR = 1.28 (95 % CI: 
      1.05, 1.55) and 1.38 (1.15, 1.65), respectively, per each 2.7-fold increment], 
      between blood BDCM concentrations and the odds of mold [OR = 1.47 (1.24, 1.74)], 
      plant [OR = 1.25 (1.09, 1.43)], pet [OR = 1.27 (1.07, 1.52)], and food 
      sensitization [OR = 1.18 (1.03, 1.36)], and between blood brominated THM 
      (Br-THMs: sum of BDCM, DBCM, and TBM) and total THM (TTHMs: sum of 4 THMs) 
      concentrations and the odds of mold [OR = 1.52 (1.30 1.78) and 1.30 (1.03, 1.65), 
      respectively], dust mite [OR = 1.39 (1.06, 1.82) and 1.45 (1.06, 1.98), 
      respectively], and pet sensitization [OR = 1.42 (1.05, 1.92) and 1.54 (1.19, 
      1.98), respectively]. CONCLUSION: Higher blood concentrations of THMs were 
      associated with a greater risk of allergic sensitization among U.S. adolescents 
      but not in adults.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Sun, Yang
AU  - Sun Y
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, United States; Department of Epidemiology, Harvard T.H. Chan 
      School of Public Health, Boston, MA 02115, United States.
FAU - Wang, Yi-Xin
AU  - Wang YX
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, United States; Department of Nutrition, Harvard T.H. Chan 
      School of Public Health, Boston, MA 02115, United States. Electronic address: 
      yixinwang@hsph.harvard.edu.
FAU - Mustieles, Vicente
AU  - Mustieles V
AD  - University of Granada, Center for Biomedical Research (CIBM), 18016 Granada, 
      Spain; Instituto de Investigacion Biosanitaria Ibs GRANADA, 18016 Granada, Spain; 
      Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 
      18016 Granada, Spain.
FAU - Shan, Zhilei
AU  - Shan Z
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical 
      College, Huazhong University of Science and Technology, Wuhan 430030, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, United States.
FAU - Messerlian, Carmen
AU  - Messerlian C
AD  - Department of Environmental Health, Harvard T.H. Chan School of Public Health, 
      Boston, MA 02115, United States; Department of Epidemiology, Harvard T.H. Chan 
      School of Public Health, Boston, MA 02115, United States.
LA  - eng
GR  - R01 ES031657/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20230209
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 7LN464CH2O (bromodichloromethane)
RN  - 3T4AJR1H24 (chlorodibromomethane)
RN  - 0 (Trihalomethanes)
RN  - 0 (Allergens)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - *Trihalomethanes
MH  - Allergens
MH  - *Water Pollutants, Chemical
PMC - PMC10006400
MID - NIHMS1874372
OTO - NOTNLM
OT  - Allergic sensitization
OT  - Antibodies
OT  - Disinfection by-products
OT  - NHANES
OT  - Water pollution
COIS- Declaration of competing interest The authors declare the following financial 
      interests/personal relationships which may be considered as potential competing 
      interests: Carmen Messerlian reports financial support was provided by National 
      Institutes of Health. Yi-Xin Wang reports financial support was provided by 
      National Natural Science Foundation of China.
EDAT- 2023/02/11 06:00
MHDA- 2023/03/14 06:00
PMCR- 2024/05/01
CRDT- 2023/02/10 19:27
PHST- 2022/10/04 00:00 [received]
PHST- 2023/01/30 00:00 [revised]
PHST- 2023/02/04 00:00 [accepted]
PHST- 2023/02/11 06:00 [pubmed]
PHST- 2023/03/14 06:00 [medline]
PHST- 2023/02/10 19:27 [entrez]
PHST- 2024/05/01 00:00 [pmc-release]
AID - S0048-9697(23)00716-7 [pii]
AID - 10.1016/j.scitotenv.2023.162100 [doi]
PST - ppublish
SO  - Sci Total Environ. 2023 May 1;871:162100. doi: 10.1016/j.scitotenv.2023.162100. 
      Epub 2023 Feb 9.