PMID- 36765118
OWN - NLM
STAT- MEDLINE
DCOM- 20230214
LR  - 20230331
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Feb 10
TI  - Patterns of Arc mRNA expression in the rat brain following dual recall of fear- 
      and reward-based socially acquired information.
PG  - 2429
LID - 10.1038/s41598-023-29609-6 [doi]
LID - 2429
AB  - Learning can occur via direct experience or through observation of another 
      individual (i.e., social learning). While research focused on understanding the 
      neural mechanisms of direct learning is prevalent, less work has examined the 
      brain circuitry mediating the acquisition and recall of socially acquired 
      information. Here, we aimed to further elucidate the mechanisms underlying recall 
      of socially acquired information by having male and female rats sequentially 
      recall a socially transmitted food preference (STFP) and a fear association via 
      fear conditioning by-proxy (FCbP). Brain tissue was processed for mRNA expression 
      of the immediate early gene (IEG) Arc, which expresses in the nucleus following 
      transcription before migrating to the cytoplasm over the next 25 min. Given this 
      timeframe, we could identify whether Arc transcription was triggered by STFP 
      recall, FCbP recall, or both. Contrary to past research, we found no differences 
      in any Arc expression measures across a number of prefrontal regions and the 
      ventral CA3 of the hippocampus between controls, demonstrators, and observers. We 
      theorize that these results may indicate that relatively little Arc-dependent 
      neural restructuring is taking place in the prefrontal cortices and ventral CA3 
      following recall of recently socially acquired information or directly acquired 
      fear associations in these areas.
CI  - (c) 2023. The Author(s).
FAU - Agee, Laura A
AU  - Agee LA
AD  - Department of Psychology, The University of Texas at Austin, Austin, TX, USA.
FAU - Hilz, Emily N
AU  - Hilz EN
AD  - Department of Psychology, The University of Texas at Austin, Austin, TX, USA.
FAU - Jun, Dohyun
AU  - Jun D
AD  - Department of Psychology, The University of Texas at Austin, Austin, TX, USA.
FAU - Nemchek, Victoria
AU  - Nemchek V
AD  - Department of Psychology, The University of Texas at Austin, Austin, TX, USA.
FAU - Lee, Hongjoo J
AU  - Lee HJ
AD  - Department of Psychology, The University of Texas at Austin, Austin, TX, USA.
AD  - Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA.
FAU - Monfils, Marie-H
AU  - Monfils MH
AD  - Department of Psychology, The University of Texas at Austin, Austin, TX, USA. 
      marie.monfils@utexas.edu.
AD  - Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA. 
      marie.monfils@utexas.edu.
LA  - eng
GR  - T32 MH106454/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20230210
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Rats
MH  - Male
MH  - Female
MH  - Animals
MH  - *Mental Recall
MH  - *Hippocampus/metabolism
MH  - Fear
MH  - Reward
MH  - RNA, Messenger/genetics/metabolism
PMC - PMC9918527
COIS- The authors declare no competing interests.
EDAT- 2023/02/11 06:00
MHDA- 2023/02/15 06:00
PMCR- 2023/02/10
CRDT- 2023/02/10 23:44
PHST- 2022/11/05 00:00 [received]
PHST- 2023/02/07 00:00 [accepted]
PHST- 2023/02/11 06:00 [pubmed]
PHST- 2023/02/15 06:00 [medline]
PHST- 2023/02/10 23:44 [entrez]
PHST- 2023/02/10 00:00 [pmc-release]
AID - 10.1038/s41598-023-29609-6 [pii]
AID - 29609 [pii]
AID - 10.1038/s41598-023-29609-6 [doi]
PST - epublish
SO  - Sci Rep. 2023 Feb 10;13(1):2429. doi: 10.1038/s41598-023-29609-6.