PMID- 36766520
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230213
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 13
IP  - 3
DP  - 2023 Jan 23
TI  - Transcranial Magnetic Stimulation Improves Executive Functioning through 
      Modulation of Social Cognitive Networks in Patients with Mild Cognitive 
      Impairment: Preliminary Results.
LID - 10.3390/diagnostics13030415 [doi]
LID - 415
AB  - (1) Background: Patients with mild cognitive impairment (MCI) often present 
      impairment in executive functions (EFs). This study aimed to investigate the 
      effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) on 
      EFs in patients with MCI. (2) Methods: A prospective trial was conducted on 11 
      patients with MCI. Participants underwent 25 min of 20 Hz rTMS for ten days on 
      the right temporo-parietal junction (RTPJ) and medial prefrontal cortex (MPFC). 
      Before (T0) and after rTMS treatment (T1), global cognitive profile and EFs were 
      investigated using the Montreal cognitive assessment (MoCA), trial making test 
      (TMT) A and B, and frontal assessment battery (FAB). Depression symptoms were 
      assessed using the geriatric depression scale (GDS). Statistical analysis 
      included Wilcoxon signed-rank test. (3) Results: After treatment, patients showed 
      a significant improvement in the MoCA EFs subtask (T0 vs. T1, p = 0.015) and 
      TMT-B (T0 vs. T1, p = 0.028). Five MCI patients with EF impairment showed full 
      recovery of these deficits. No significant changes in the GDS were observed. (4) 
      Conclusions: rTMS stimulation over the TPJ and MPFC induced significant 
      short-term improvements in EFs in MCI patients. These findings suggest that the 
      TPJ and MPFC may be involved in the attention-executive skills to redirect 
      attention toward behaviorally relevant stimuli.
FAU - Sacco, Leonardo
AU  - Sacco L
AD  - Neuropsychology and Behavioral Neurology Research Unit, Neurocenter of Southern 
      Switzerland, EOC, 6900 Lugano, Switzerland.
FAU - Ceroni, Martino
AU  - Ceroni M
AUID- ORCID: 0000-0002-9470-1849
AD  - Neuropsychology and Behavioral Neurology Research Unit, Neurocenter of Southern 
      Switzerland, EOC, 6900 Lugano, Switzerland.
FAU - Pacifico, Deborah
AU  - Pacifico D
AD  - Neuropsychology and Behavioral Neurology Research Unit, Neurocenter of Southern 
      Switzerland, EOC, 6900 Lugano, Switzerland.
AD  - Faculty of Biomedical Sciences, Universita della Svizzera Italiana, 6900 Lugano, 
      Switzerland.
FAU - Zerboni, Giorgia
AU  - Zerboni G
AD  - Neuropsychology and Behavioral Neurology Research Unit, Neurocenter of Southern 
      Switzerland, EOC, 6900 Lugano, Switzerland.
FAU - Rossi, Stefania
AU  - Rossi S
AD  - Neuropsychology and Behavioral Neurology Research Unit, Neurocenter of Southern 
      Switzerland, EOC, 6900 Lugano, Switzerland.
FAU - Galati, Salvatore
AU  - Galati S
AD  - Faculty of Biomedical Sciences, Universita della Svizzera Italiana, 6900 Lugano, 
      Switzerland.
AD  - Movement Disorders Unit, Neurocenter of Southern Switzerland, EOC, 6900 Lugano, 
      Switzerland.
FAU - Caverzasio, Serena
AU  - Caverzasio S
AD  - Faculty of Biomedical Sciences, Universita della Svizzera Italiana, 6900 Lugano, 
      Switzerland.
AD  - Movement Disorders Unit, Neurocenter of Southern Switzerland, EOC, 6900 Lugano, 
      Switzerland.
FAU - Kaelin-Lang, Alain
AU  - Kaelin-Lang A
AD  - Faculty of Biomedical Sciences, Universita della Svizzera Italiana, 6900 Lugano, 
      Switzerland.
AD  - Movement Disorders Unit, Neurocenter of Southern Switzerland, EOC, 6900 Lugano, 
      Switzerland.
AD  - Department of Neurology, Inselspital, Bern University Hospital, 3010 Bern, 
      Switzerland.
FAU - Riccitelli, Gianna C
AU  - Riccitelli GC
AUID- ORCID: 0000-0002-1202-5534
AD  - Neuropsychology and Behavioral Neurology Research Unit, Neurocenter of Southern 
      Switzerland, EOC, 6900 Lugano, Switzerland.
AD  - Faculty of Biomedical Sciences, Universita della Svizzera Italiana, 6900 Lugano, 
      Switzerland.
LA  - eng
GR  - 2020-00434/Advisory Board of Ente Ospedaliero Cantonale/
PT  - Journal Article
DEP - 20230123
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC9914912
OTO - NOTNLM
OT  - cognition
OT  - executive functions
OT  - mild cognitive impairment
OT  - transcranial magnetic stimulation
OT  - treatment
COIS- The authors declare no conflict of interest.
EDAT- 2023/02/12 06:00
MHDA- 2023/02/12 06:01
PMCR- 2023/01/23
CRDT- 2023/02/11 01:08
PHST- 2022/11/21 00:00 [received]
PHST- 2023/01/17 00:00 [revised]
PHST- 2023/01/18 00:00 [accepted]
PHST- 2023/02/11 01:08 [entrez]
PHST- 2023/02/12 06:00 [pubmed]
PHST- 2023/02/12 06:01 [medline]
PHST- 2023/01/23 00:00 [pmc-release]
AID - diagnostics13030415 [pii]
AID - diagnostics-13-00415 [pii]
AID - 10.3390/diagnostics13030415 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2023 Jan 23;13(3):415. doi: 10.3390/diagnostics13030415.