PMID- 3676757
OWN - NLM
STAT- MEDLINE
DCOM- 19871222
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 420
IP  - 2
DP  - 1987 Sep 15
TI  - Prolactin secretion in posterior pituitary lobectomized rats: differential 
      effects of 5-hydroxytryptophan and ether.
PG  - 227-32
AB  - The objective of this study was to determine whether the posterior pituitary 
      mediates the prolactin (PRL) releasing activities of serotonin and ether. 
      Ovariectomized (OVEX) rats were subjected to posterior pituitary lobectomy 
      (LOBEX) or sham surgery (SHAM). Either 1 or 12 days after surgery, rats were 
      injected i.v. with 20 mg/kg b. wt. of 5-hydroxytryptophan (5-HTP), which is a 
      precursor of serotonin. A second group of rats was exposed to ether vapors for 10 
      min. Blood was collected from a jugular cannula before and after the treatments 
      and analyzed for PRL. On either 1 or 12 days after surgery, injection of 5-HTP 
      increased plasma PRL levels 5-10 fold in both LOBEX and SHAM rats. This was 
      followed by a decline to preinjection levels within 60-90 min. LOBEX and SHAM 
      male rats which were injected i.p. with 50 mg/kg b. wt. of 5-HTP, also showed 
      marked and similar elevations of plasma PRL levels 12 days after surgery. 
      Exposure of OVEX rats to ether elicited a 2-3 fold rise in plasma PRL levels only 
      on day 1, but not on day 12, after LOBEX. The ether-induced rise in PRL was 
      similar in SHAM rats tested on both days. These results indicate that the 
      5-HTP-induced rise in plasma PRL levels is independent of the posterior 
      pituitary, regardless of the sex, the route of drug administration or the length 
      of time after surgery. In contrast, the PRL response to ether stress is 
      diminished within 12 days after LOBEX. The evidence that the PRL responses to 
      5-HTP and to ether might be mediated via different neuronal mechanisms is 
      discussed.
FAU - Murai, I
AU  - Murai I
AD  - Department of Physiology and Biophysics, Indiana University School of Medicine, 
      Indianapolis 46223.
FAU - Ben-Jonathan, N
AU  - Ben-Jonathan N
LA  - eng
GR  - NS 13234/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Ethyl Ethers)
RN  - 0F5N573A2Y (Ether)
RN  - 333DO1RDJY (Serotonin)
RN  - 9002-62-4 (Prolactin)
SB  - IM
MH  - Animals
MH  - Ether/*pharmacology
MH  - Ethyl Ethers/*pharmacology
MH  - Female
MH  - Hypophysectomy
MH  - Male
MH  - Ovariectomy
MH  - Pituitary Gland, Posterior/drug effects/*metabolism/surgery
MH  - Prolactin/blood/*metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/administration & dosage/*pharmacology
EDAT- 1987/09/15 00:00
MHDA- 1987/09/15 00:01
CRDT- 1987/09/15 00:00
PHST- 1987/09/15 00:00 [pubmed]
PHST- 1987/09/15 00:01 [medline]
PHST- 1987/09/15 00:00 [entrez]
AID - 0006-8993(87)91242-X [pii]
AID - 10.1016/0006-8993(87)91242-x [doi]
PST - ppublish
SO  - Brain Res. 1987 Sep 15;420(2):227-32. doi: 10.1016/0006-8993(87)91242-x.